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- W2556135024 abstract "Background: Positive airway pressure therapy (PAP) is reported to improve the mortality of OSAS with daytime hypercapnia . However, the data on long-term prognosis in hypercapnic OSAS undergoing CPAP therapy are limited. Objective: Our study objectives were to investigate the survival and explore prognostic factors in OSAS with daytime hypercapnia undergoing CPAP therapy. Methods: Thirty-seven patients who were diagnosed OSAS with daytime hypercapnia (PaCO 2 > 45mmHg) were enrolled. All of them are treated with CPAP therapy. The patients were divided into 2 groups according to the improvement of PaCO 2 by CPAP therapy after 3 months (the change in PaCO 2 ≥ 5mmHg; good responder, the change in PaCO 2 Results: During median follow-up of 125 months, All-cause mortality was 33%, in poor responder group to CPAP therapy. In contrast, all of the patients in good responder group survived (log-lank, p = 0.0115). In univariate analysis, patients with PaO 2 2 >45 mmHg at baseline had poor prognosis (p =0.0013, p 2 after CPAP therapy was independent predictor of mortality (p = 0.042). In contrast, neither BMI nor results of pulmonary function tests was linked to their survival. Conclusion: The presence of hypercapnia which is resistant to CPAP therapy predicts poor prognosis in hypercapnic OSAS." @default.
- W2556135024 created "2016-11-30" @default.
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- W2556135024 date "2016-09-01" @default.
- W2556135024 modified "2023-09-27" @default.
- W2556135024 title "Persistent daytime hypercapnia predicts poor prognosis in OSAS undergoing CPAP therapy" @default.
- W2556135024 doi "https://doi.org/10.1183/13993003.congress-2016.pa3424" @default.
- W2556135024 hasPublicationYear "2016" @default.
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