Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556153975> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2556153975 endingPage "549" @default.
- W2556153975 startingPage "549" @default.
- W2556153975 abstract "2372 Anti-angiogenic agents selective for tumor vasculature have shown promise as anti-cancer therapies in clinical trials. We evaluated the potential anti-angiogenic role of a novel class of orally available small molecules known as selective cytokine inhibitory drugs or SelCids. One member of this class of compounds, designated CC10004, was investigated for its effects on endothelial cells, new blood vessel formation and wound healing. Cell proliferation was determined for human umbilical vein endothelial cells (HUVEC), and two human colon cancer cell lines (HT29 or KM12) using a WST-1 cell proliferation assay. Effects on vessel growth were measured using the rat aortic ring assay and the chicken chorioallantoic membrane assay (CAM). Wound healing was assessed in C57/Bl 6 mice following daily topical administration of the compound or control carrier using tensile strength assessment (Instron Tensometer) and by calculating time to wound closure. CC10004 demonstrated selective inhibitory effects on human umbilical vein endothelial cells (HUVEC) but not on HT29 or KM12, two human colon cancer cell lines, at doses from 73 to 7300 nM compared to controls (HUVEC 73 nM 61.4% decrease p" @default.
- W2556153975 created "2016-11-30" @default.
- W2556153975 creator A5000805683 @default.
- W2556153975 creator A5003655999 @default.
- W2556153975 creator A5010712150 @default.
- W2556153975 creator A5017572254 @default.
- W2556153975 creator A5032165288 @default.
- W2556153975 creator A5043825904 @default.
- W2556153975 creator A5045747037 @default.
- W2556153975 creator A5046351987 @default.
- W2556153975 creator A5081233015 @default.
- W2556153975 date "2004-04-01" @default.
- W2556153975 modified "2023-09-23" @default.
- W2556153975 title "A novel PDE4 inhibitory agent with endothelial cell specific activity." @default.
- W2556153975 hasPublicationYear "2004" @default.
- W2556153975 type Work @default.
- W2556153975 sameAs 2556153975 @default.
- W2556153975 citedByCount "0" @default.
- W2556153975 crossrefType "journal-article" @default.
- W2556153975 hasAuthorship W2556153975A5000805683 @default.
- W2556153975 hasAuthorship W2556153975A5003655999 @default.
- W2556153975 hasAuthorship W2556153975A5010712150 @default.
- W2556153975 hasAuthorship W2556153975A5017572254 @default.
- W2556153975 hasAuthorship W2556153975A5032165288 @default.
- W2556153975 hasAuthorship W2556153975A5043825904 @default.
- W2556153975 hasAuthorship W2556153975A5045747037 @default.
- W2556153975 hasAuthorship W2556153975A5046351987 @default.
- W2556153975 hasAuthorship W2556153975A5081233015 @default.
- W2556153975 hasConcept C121608353 @default.
- W2556153975 hasConcept C123012128 @default.
- W2556153975 hasConcept C126322002 @default.
- W2556153975 hasConcept C1491633281 @default.
- W2556153975 hasConcept C202751555 @default.
- W2556153975 hasConcept C203014093 @default.
- W2556153975 hasConcept C2777411675 @default.
- W2556153975 hasConcept C2777834122 @default.
- W2556153975 hasConcept C2780269544 @default.
- W2556153975 hasConcept C2780394083 @default.
- W2556153975 hasConcept C502942594 @default.
- W2556153975 hasConcept C526805850 @default.
- W2556153975 hasConcept C54355233 @default.
- W2556153975 hasConcept C55493867 @default.
- W2556153975 hasConcept C62112901 @default.
- W2556153975 hasConcept C71924100 @default.
- W2556153975 hasConcept C81885089 @default.
- W2556153975 hasConcept C86803240 @default.
- W2556153975 hasConcept C96232424 @default.
- W2556153975 hasConcept C97230052 @default.
- W2556153975 hasConcept C98274493 @default.
- W2556153975 hasConceptScore W2556153975C121608353 @default.
- W2556153975 hasConceptScore W2556153975C123012128 @default.
- W2556153975 hasConceptScore W2556153975C126322002 @default.
- W2556153975 hasConceptScore W2556153975C1491633281 @default.
- W2556153975 hasConceptScore W2556153975C202751555 @default.
- W2556153975 hasConceptScore W2556153975C203014093 @default.
- W2556153975 hasConceptScore W2556153975C2777411675 @default.
- W2556153975 hasConceptScore W2556153975C2777834122 @default.
- W2556153975 hasConceptScore W2556153975C2780269544 @default.
- W2556153975 hasConceptScore W2556153975C2780394083 @default.
- W2556153975 hasConceptScore W2556153975C502942594 @default.
- W2556153975 hasConceptScore W2556153975C526805850 @default.
- W2556153975 hasConceptScore W2556153975C54355233 @default.
- W2556153975 hasConceptScore W2556153975C55493867 @default.
- W2556153975 hasConceptScore W2556153975C62112901 @default.
- W2556153975 hasConceptScore W2556153975C71924100 @default.
- W2556153975 hasConceptScore W2556153975C81885089 @default.
- W2556153975 hasConceptScore W2556153975C86803240 @default.
- W2556153975 hasConceptScore W2556153975C96232424 @default.
- W2556153975 hasConceptScore W2556153975C97230052 @default.
- W2556153975 hasConceptScore W2556153975C98274493 @default.
- W2556153975 hasLocation W25561539751 @default.
- W2556153975 hasOpenAccess W2556153975 @default.
- W2556153975 hasPrimaryLocation W25561539751 @default.
- W2556153975 hasRelatedWork W123691288 @default.
- W2556153975 hasRelatedWork W1991460351 @default.
- W2556153975 hasRelatedWork W1996852003 @default.
- W2556153975 hasRelatedWork W2025502520 @default.
- W2556153975 hasRelatedWork W2026817099 @default.
- W2556153975 hasRelatedWork W2097591347 @default.
- W2556153975 hasRelatedWork W2156831659 @default.
- W2556153975 hasRelatedWork W2163987083 @default.
- W2556153975 hasRelatedWork W2353928400 @default.
- W2556153975 hasRelatedWork W2354125101 @default.
- W2556153975 hasRelatedWork W2356451831 @default.
- W2556153975 hasRelatedWork W2361480875 @default.
- W2556153975 hasRelatedWork W2363229567 @default.
- W2556153975 hasRelatedWork W2366015183 @default.
- W2556153975 hasRelatedWork W2375214518 @default.
- W2556153975 hasRelatedWork W2379313573 @default.
- W2556153975 hasRelatedWork W2399790470 @default.
- W2556153975 hasRelatedWork W2407119982 @default.
- W2556153975 hasRelatedWork W2419239879 @default.
- W2556153975 hasRelatedWork W2805049287 @default.
- W2556153975 hasVolume "64" @default.
- W2556153975 isParatext "false" @default.
- W2556153975 isRetracted "false" @default.
- W2556153975 magId "2556153975" @default.
- W2556153975 workType "article" @default.