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- W2556163399 abstract "Abstract A new peroxide of xanthone ( 1 ), together with five analogues ( 2 – 6 ), was obtained from horseradish peroxidase (HRP) catalysed biotransformation of α -mangostin. In order to increase the yield of compound 1 , the environmental pH was succinctly adjusted, and as a result, compound 1 was formed with considerable selectivity. The anticancer potential of compound 1 , a pentacyclic xanthone with a 1,2-dioxolane ring, was investigated due to its potent cytotoxic activity. The results showed that apoptosis induced by compound 1 in human hepatocellular carcinoma (HepG2) cell was associated with activation of caspase-dependent apoptotic pathway, the generation of reactive oxygen species (ROS) and the activation of c-Jun N-terminal kinases (JNK). In summary, compound 1 with a peroxide group was biosynthesized in considerable yield through pH-switched biotransformation catalysed by HRP, which could be further developed as a promising candidate in the treatment of liver cancer." @default.
- W2556163399 created "2016-11-30" @default.
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- W2556163399 date "2017-01-01" @default.
- W2556163399 modified "2023-10-13" @default.
- W2556163399 title "Polycyclic xanthones via pH-switched biotransformation of α-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro" @default.
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- W2556163399 doi "https://doi.org/10.1016/j.jff.2016.11.022" @default.
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