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- W2556174920 abstract "In the 1990s, serotonin receptor agonist 5-HT 1B/1D (the triptans) became available on the market for migraine treatment. Although the triptans are highly effective in aborting migraine attacks, the vasoconstrictor effect in cerebral and coronary territory limits their use. In the “post-triptans” era, new molecules, without vasoactive components are about to expand migraine treatment armamentarium, such as: serotonin 5-HT 1F receptor agonists, calcitonin gene related peptide (CGRP) receptor antagonists (olcegepant, telcagepant) and monoclonal antibodies (mAbs) targeting the CGRP, glutamate receptor (AMPA/kainate) antagonists, transient receptor potential vanilloid (TRV1) antagonists, nitric oxide (NO) synthesis inhibitors, prostanoid E4 receptor antagonists. Rezumat In anii 1990, au aparut pe piaţa farmaceutica agoniștii receptorilor serotoninei 5-HT 1B/1D (triptanii) pentru tratamentul atacurilor migrenoase. Desi triptanii sunt foarte eficienţi in atacurile migrenoase, folosirea lor este limitata de efectul vasoconstrictor din teritoriul cerebral si coronarian. In era „post-triptani”, noi molecule, fara componente vasoactive, sunt pe cale sa completeze armamentarium-ul pentru tratamentul migrenei, precum: agonistii de receptori 5-HT 1F , antagonistii receptorilor CGRP si anticorpii monoclonali anti-CGRP, antagonistii receptorilor de glutamat (AMPA/kainate), antagonisti ai TRV1, inhibitori ai sintezei de NO, antagonisti ai receptorilor prostanoid E3." @default.
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- W2556174920 date "2015-01-01" @default.
- W2556174920 modified "2023-10-18" @default.
- W2556174920 title "NEW MOLLECULES IN MIGRAINE TREATMENT" @default.
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