FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556303941> ?p ?o ?g. }

• W2556303941 endingPage "85" @default.
• W2556303941 startingPage "73" @default.
• W2556303941 abstract "A variety of mitochondria-targeted small molecules have been invented to manipulate mitochondrial redox activities and improve function in certain disease states. 3-Hydroxypropyl-triphenylphosphonium-conjugated imidazole-substituted oleic acid (TPP-IOA) was developed as a specific inhibitor of cytochrome c peroxidase activity that inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. Here we evaluate the effects of TPP-IOA on oxidative phosphorylation in isolated mitochondria and on mitochondrial function in live cells. We demonstrate that, at concentrations similar to those required to achieve inhibition of cytochrome c peroxidase activity, TPP-IOA perturbs oxidative phosphorylation in isolated mitochondria. In live SH-SY5Y cells, TPP-IOA partially collapsed mitochondrial membrane potential, caused extensive fragmentation of the mitochondrial network, and decreased apparent mitochondrial abundance within 3 h of exposure. Many cultured cell lines rely primarily on aerobic glycolysis, potentially making them less sensitive to small molecules disrupting oxidative phosphorylation. We therefore determined the anti-apoptotic efficacy of TPP-IOA in SH-SY5Y cells growing in glucose or in galactose, the latter of which increases reliance on oxidative phosphorylation for ATP supply. The anti-apoptotic activity of TPP-IOA that was observed in glucose media was not seen in galactose media. It therefore appears that, at concentrations required to inhibit cytochrome c peroxidase activity, TPP-IOA perturbs oxidative phosphorylation. In light of these data it is predicted that potential future therapeutic applications of TPP-IOA will be restricted to highly glycolytic cell types with limited reliance on oxidative phosphorylation." @default.
• W2556303941 created "2016-11-30" @default.
• W2556303941 creator A5063497866 @default.
• W2556303941 creator A5066815946 @default.
• W2556303941 creator A5069548274 @default.
• W2556303941 creator A5088111028 @default.
• W2556303941 date "2017-01-01" @default.
• W2556303941 modified "2023-10-11" @default.
• W2556303941 title "The mitochondria-targeted imidazole substituted oleic acid ‘TPP-IOA’ affects mitochondrial bioenergetics and its protective efficacy in cells is influenced by cellular dependence on aerobic metabolism" @default.
• W2556303941 cites W1483212110 @default.
• W2556303941 cites W1506642042 @default.
• W2556303941 cites W173237302 @default.
• W2556303941 cites W1939952622 @default.
• W2556303941 cites W1954131635 @default.
• W2556303941 cites W1958746655 @default.
• W2556303941 cites W1964483580 @default.
• W2556303941 cites W1965665318 @default.
• W2556303941 cites W1967880167 @default.
• W2556303941 cites W1968642106 @default.
• W2556303941 cites W1975836370 @default.
• W2556303941 cites W1977219317 @default.
• W2556303941 cites W1985590779 @default.
• W2556303941 cites W1987695736 @default.
• W2556303941 cites W1992423211 @default.
• W2556303941 cites W1999378703 @default.
• W2556303941 cites W2001110762 @default.
• W2556303941 cites W2001675597 @default.
• W2556303941 cites W2001788426 @default.
• W2556303941 cites W2004428815 @default.
• W2556303941 cites W2004706975 @default.
• W2556303941 cites W2013557200 @default.
• W2556303941 cites W2013970530 @default.
• W2556303941 cites W2015032452 @default.
• W2556303941 cites W2017692041 @default.
• W2556303941 cites W2019802526 @default.
• W2556303941 cites W2022108138 @default.
• W2556303941 cites W2023448800 @default.
• W2556303941 cites W2026738371 @default.
• W2556303941 cites W2039190163 @default.
• W2556303941 cites W2044998619 @default.
• W2556303941 cites W2046407094 @default.
• W2556303941 cites W2048934049 @default.
• W2556303941 cites W2049016912 @default.
• W2556303941 cites W2052401089 @default.
• W2556303941 cites W2054837775 @default.
• W2556303941 cites W2060166470 @default.
• W2556303941 cites W2061490621 @default.
• W2556303941 cites W2061982111 @default.
• W2556303941 cites W2062897750 @default.
• W2556303941 cites W2066403680 @default.
• W2556303941 cites W2070764343 @default.
• W2556303941 cites W2071585087 @default.
• W2556303941 cites W2074621487 @default.
• W2556303941 cites W2075508190 @default.
• W2556303941 cites W2076769172 @default.
• W2556303941 cites W2080891051 @default.
• W2556303941 cites W2081081915 @default.
• W2556303941 cites W2082261245 @default.
• W2556303941 cites W2083595371 @default.
• W2556303941 cites W2084982869 @default.
• W2556303941 cites W2085804147 @default.
• W2556303941 cites W2089663038 @default.
• W2556303941 cites W2091296592 @default.
• W2556303941 cites W2095987251 @default.
• W2556303941 cites W2096847996 @default.
• W2556303941 cites W2102626915 @default.
• W2556303941 cites W2105604713 @default.
• W2556303941 cites W2110312513 @default.
• W2556303941 cites W2111501046 @default.
• W2556303941 cites W2113479696 @default.
• W2556303941 cites W2115054403 @default.
• W2556303941 cites W2116729573 @default.
• W2556303941 cites W2117911689 @default.
• W2556303941 cites W2119683782 @default.
• W2556303941 cites W2124161324 @default.
• W2556303941 cites W2125461230 @default.
• W2556303941 cites W2127072819 @default.
• W2556303941 cites W2143588920 @default.
• W2556303941 cites W2161032546 @default.
• W2556303941 cites W2162248789 @default.
• W2556303941 cites W2164174765 @default.
• W2556303941 cites W2168283408 @default.
• W2556303941 cites W2216742918 @default.
• W2556303941 cites W2403543580 @default.
• W2556303941 cites W4237644036 @default.
• W2556303941 cites W618206895 @default.
• W2556303941 cites W75797419 @default.
• W2556303941 doi "https://doi.org/10.1016/j.bbabio.2016.11.005" @default.
• W2556303941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27836699" @default.
• W2556303941 hasPublicationYear "2017" @default.
• W2556303941 type Work @default.
• W2556303941 sameAs 2556303941 @default.
• W2556303941 citedByCount "11" @default.
• W2556303941 countsByYear W25563039412017 @default.
• W2556303941 countsByYear W25563039412018 @default.
• W2556303941 countsByYear W25563039412019 @default.
• W2556303941 countsByYear W25563039412020 @default.
• W2556303941 countsByYear W25563039412021 @default.

• next