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• W2556348543 abstract "// Xinglu Chen 1, * , Sansan Chen 2, * , Nana Pei 3, * , Yingying Mao 1 , Shengyao Wang 1 , Renhe Yan 1 , Na Bai 4 , Andrew Li 5 , Yanling Zhang 1 , Hongyan Du 1 , Baihong Chen 1 , Colin Sumners 6 , Jinlong Li 1 , Hongwei Li 1 1 School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China 2 Department of Urology, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China 3 Department of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China 4 Deparement of Nuclear Medicine, People’s Hospital of Yuxi City, Yuxi, Yunnan, China 5 Department of Biomedical Engineering, The Johns University School of Medicine, Baltimore, USA 6 Departments of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA * These authors contributed equally to this work Correspondence to: Hongwei Li, email: hongwei1@yahoo.com Jinglong Li, email: lijinlong75@126.com Keywords: Ang-(1-7), lung cancer, adeno-associated viral vector, DNA synthesis, proliferation Received: October 07, 2016      Accepted: November 11, 2016      Published: November 16, 2016 ABSTRACT Ang-(1-7) inhibits lung cancer cell growth both in vitro and in vivo . However, the molecular mechanism of action is unclear and also the rapid degradation of Ang-(1-7) in vivo limits its clinical application. Here, we have demonstrated that Ang- (1-7) inhibits lung cancer cell growth by interrupting pre-replicative complex assembly and restrains epithelial-mesenchymal transition via Cdc6 inhibition. Furthermore, we constructed a mutant adeno-associated viral vector AAV8 (Y733F) that produced stable and high efficient Ang-(1-7) expression in a xenograft tumor model. The results show that AAV8-mediated Ang-(1-7) over-expression can remarkably suppress tumor growth in vivo by down-regulating Cdc6 and anti-angiogenesis. Ang-(1-7) over-expression via the AAV8 method may be a promising strategy for lung cancer treatment." @default.
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• W2556348543 date "2016-11-16" @default.
• W2556348543 modified "2023-10-17" @default.
• W2556348543 title "AAV-Mediated angiotensin 1-7 overexpression inhibits tumor growth of lung cancer <i>in vitro</i> and <i>in vivo</i>" @default.
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• W2556348543 doi "https://doi.org/10.18632/oncotarget.13396" @default.
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