FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556372015> ?p ?o ?g. }

• W2556372015 abstract "Background Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against constituents of primary granules of neutrophils. ANCA are the serological marker of some idiopathic systemic vasculitides, predominantly involving small and medium-sized blood vessels, such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), which are known as the ANCA-associated vasculitis (AAV). Although ANCA are the serological hallmark of AAV, ANCA have been reported in a number of other conditions including infections, malignancies, connective-tissue diseases, liver and gastrointestinal diseases, renal diseases, and other vasculitides. Many studies have evaluated the clinical value of ANCA testing, but few analyze ANCA utility under actual routine conditions in unselected patients with the usual laboratory techniques. Objectives Our aim was to evaluate the positive predictive value (PPV) of ANCA testing in a cohort of unselected patients from a Spanish tertiary hospital. Methods We reviewed the clinical charts of patients with positive ANCA testing between January 2014 and December 2014 at the Immunology Department from a 1.000-bed tertiary teaching hospital from Barcelona (Spain). Detection methods included indirect immunofluorescence (IIF) for all testing request and chemiluminescent immuno-assay (CLIA) for antibodies against mieloperoxidase (MPO) and proteinase 3 (PR3) in patients with positive IIF. Results Out of 1615 patients with ANCA testing request, 298 (18.5%) tested positive. Atypical pattern (X-ANCA) was the most frequent (50.3%) over perinuclear pattern (P-ANCA) (27.5%) and cytoplasmatic pattern (C-ANCA) (22.1%). 35.4% of P-ANCA and 36.4% of C-ANCA were positive for MPO-ANCA and PR3-ANCA, respectively, whereas 97.3% of X-ANCA tested negative by CLIA. 53 (18.2%) patients with positive ANCA had a diagnosis of ANCA-associated vasculitis (AAV). Other diagnosis were the following: 26 (8.9%) connective tissue diseases, 13 (4.5%) vasculitides non-AAV, 13 (4.5%) autoimmune liver diseases and 11 (3.8%) inflammatory bowel disease. The combination of IIF and CLIA showed the best diagnostic accuracy. P-ANCA with anti-MPO had a PPV of 75% for AAV, and PPV of C-ANCA with anti-PR3 was 70.8% for GPA. Conclusions This study proves that ANCA testing with modern commonly commercially available methods has an elevated PPV for AAV in routine clinical practice. References Bosch X, Guilabert A, Font J. Antineutrophil cytoplasmic antibodies. Lancet 2006;368:404–418. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013;65:1–11. Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al. International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol. 1999;111:507–13. Schulte-Pelkum J, Radice A, Norman GL, Lpez Hoyos M, Lakos G, Buchner C, et al. Novel clinical and diagnostic aspects of antineutrophil cytoplasmic antibodies. J Immunol Res 2014;2014. Tsiveriotis K, Tsirogianni A, Pipi E, Soufleros K, Papasteriades C. Antineutrophil cytoplasmic antibodies testing in a large cohort of unselected greek patients. Autoimmune Dis. 2011;2011:626495. Disclosure of Interest None declared" @default.
• W2556372015 created "2016-11-30" @default.
• W2556372015 creator A5018310454 @default.
• W2556372015 creator A5037554534 @default.
• W2556372015 creator A5048291827 @default.
• W2556372015 creator A5060479720 @default.
• W2556372015 creator A5083708848 @default.
• W2556372015 date "2016-06-01" @default.
• W2556372015 modified "2023-10-18" @default.
• W2556372015 title "AB0549 Anca Testing in A Cohort of Patients from A Single Centre" @default.
• W2556372015 doi "https://doi.org/10.1136/annrheumdis-2016-eular.2801" @default.
• W2556372015 hasPublicationYear "2016" @default.
• W2556372015 type Work @default.
• W2556372015 sameAs 2556372015 @default.
• W2556372015 citedByCount "0" @default.
• W2556372015 crossrefType "journal-article" @default.
• W2556372015 hasAuthorship W2556372015A5018310454 @default.
• W2556372015 hasAuthorship W2556372015A5037554534 @default.
• W2556372015 hasAuthorship W2556372015A5048291827 @default.
• W2556372015 hasAuthorship W2556372015A5060479720 @default.
• W2556372015 hasAuthorship W2556372015A5083708848 @default.
• W2556372015 hasConcept C101180180 @default.
• W2556372015 hasConcept C126322002 @default.
• W2556372015 hasConcept C142724271 @default.
• W2556372015 hasConcept C159654299 @default.
• W2556372015 hasConcept C163764329 @default.
• W2556372015 hasConcept C203014093 @default.
• W2556372015 hasConcept C21194631 @default.
• W2556372015 hasConcept C24040308 @default.
• W2556372015 hasConcept C2776015282 @default.
• W2556372015 hasConcept C2776670291 @default.
• W2556372015 hasConcept C2778910314 @default.
• W2556372015 hasConcept C2778962941 @default.
• W2556372015 hasConcept C2779075594 @default.
• W2556372015 hasConcept C2779134260 @default.
• W2556372015 hasConcept C2779758542 @default.
• W2556372015 hasConcept C2781229154 @default.
• W2556372015 hasConcept C45189115 @default.
• W2556372015 hasConcept C71924100 @default.
• W2556372015 hasConcept C72563966 @default.
• W2556372015 hasConceptScore W2556372015C101180180 @default.
• W2556372015 hasConceptScore W2556372015C126322002 @default.
• W2556372015 hasConceptScore W2556372015C142724271 @default.
• W2556372015 hasConceptScore W2556372015C159654299 @default.
• W2556372015 hasConceptScore W2556372015C163764329 @default.
• W2556372015 hasConceptScore W2556372015C203014093 @default.
• W2556372015 hasConceptScore W2556372015C21194631 @default.
• W2556372015 hasConceptScore W2556372015C24040308 @default.
• W2556372015 hasConceptScore W2556372015C2776015282 @default.
• W2556372015 hasConceptScore W2556372015C2776670291 @default.
• W2556372015 hasConceptScore W2556372015C2778910314 @default.
• W2556372015 hasConceptScore W2556372015C2778962941 @default.
• W2556372015 hasConceptScore W2556372015C2779075594 @default.
• W2556372015 hasConceptScore W2556372015C2779134260 @default.
• W2556372015 hasConceptScore W2556372015C2779758542 @default.
• W2556372015 hasConceptScore W2556372015C2781229154 @default.
• W2556372015 hasConceptScore W2556372015C45189115 @default.
• W2556372015 hasConceptScore W2556372015C71924100 @default.
• W2556372015 hasConceptScore W2556372015C72563966 @default.
• W2556372015 hasLocation W25563720151 @default.
• W2556372015 hasOpenAccess W2556372015 @default.
• W2556372015 hasPrimaryLocation W25563720151 @default.
• W2556372015 hasRelatedWork W1965229624 @default.
• W2556372015 hasRelatedWork W1978609971 @default.
• W2556372015 hasRelatedWork W2032479779 @default.
• W2556372015 hasRelatedWork W2103078390 @default.
• W2556372015 hasRelatedWork W2329833060 @default.
• W2556372015 hasRelatedWork W2341047070 @default.
• W2556372015 hasRelatedWork W2361870020 @default.
• W2556372015 hasRelatedWork W2368350605 @default.
• W2556372015 hasRelatedWork W2415373071 @default.
• W2556372015 hasRelatedWork W2419614088 @default.
• W2556372015 hasRelatedWork W2500278919 @default.
• W2556372015 hasRelatedWork W2513119715 @default.
• W2556372015 hasRelatedWork W2565462827 @default.
• W2556372015 hasRelatedWork W2566895082 @default.
• W2556372015 hasRelatedWork W2754801854 @default.
• W2556372015 hasRelatedWork W2972877629 @default.
• W2556372015 hasRelatedWork W3032434679 @default.
• W2556372015 hasRelatedWork W3128827144 @default.
• W2556372015 hasRelatedWork W3181092706 @default.
• W2556372015 hasRelatedWork W2728607734 @default.
• W2556372015 isParatext "false" @default.
• W2556372015 isRetracted "false" @default.
• W2556372015 magId "2556372015" @default.
• W2556372015 workType "article" @default.