FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556397922> ?p ?o ?g. }

• W2556397922 endingPage "526" @default.
• W2556397922 startingPage "509" @default.
• W2556397922 abstract "Hirschsprung disease (HSCR) is a complex and heterogeneous disorder, characterized by a deficit in enteric nervous system. Genome-wide studies implied GABRG2, RELN and NRG3 might be involved in HSCR etiology. Here, we aimed to assess genetic variants in GABRG2, RELN and NRG3 that may confer susceptibility to HSCR and explore genetic interaction networks in HSCR.Using a strategy that combined case-control study and gene-gene interaction analysis with the MassArray system, we evaluated 24 polymorphisms within GABRG2, RELN and NRG3 in 104 HSCR cases and 151 normal controls of Han Chinese origin.We observed that seven polymorphisms showed statistically significant differences between HSCR subjects and normal controls. For each of the three genes, the haplotypes which combined eight markers were the most significant. Moreover, we recruited SNPsyn, GO enrichment and MDR analyses to interrogate the interactions among GABRG2, RELN, NRG3 and our previous identified PTCH1 gene. Significant interaction networks were found among GABRG2, RELN, and PTCH1.We provide a first indication that common variants of GABRG2, RELN and NRG3 and the GABRG2-RELN-PTCH1 interaction networks might confer altered susceptibility to HSCR in the Han Chinese population, suggesting a potential mechanism underlying HSCR pathogenesis." @default.
• W2556397922 created "2016-11-30" @default.
• W2556397922 creator A5001081815 @default.
• W2556397922 creator A5003642180 @default.
• W2556397922 creator A5008147959 @default.
• W2556397922 creator A5018534905 @default.
• W2556397922 creator A5022523014 @default.
• W2556397922 creator A5030021123 @default.
• W2556397922 creator A5042241049 @default.
• W2556397922 creator A5043817596 @default.
• W2556397922 creator A5069980840 @default.
• W2556397922 date "2016-01-01" @default.
• W2556397922 modified "2023-10-17" @default.
• W2556397922 title "Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease" @default.
• W2556397922 cites W1521968112 @default.
• W2556397922 cites W1556390817 @default.
• W2556397922 cites W1571779206 @default.
• W2556397922 cites W1927608331 @default.
• W2556397922 cites W1969861119 @default.
• W2556397922 cites W1970824185 @default.
• W2556397922 cites W1975827862 @default.
• W2556397922 cites W1978529201 @default.
• W2556397922 cites W1979890518 @default.
• W2556397922 cites W1986594335 @default.
• W2556397922 cites W2001247463 @default.
• W2556397922 cites W2006460889 @default.
• W2556397922 cites W2006778524 @default.
• W2556397922 cites W2006955426 @default.
• W2556397922 cites W2008492335 @default.
• W2556397922 cites W2015409937 @default.
• W2556397922 cites W2027504487 @default.
• W2556397922 cites W2029220352 @default.
• W2556397922 cites W2030447006 @default.
• W2556397922 cites W2038444932 @default.
• W2556397922 cites W2039279598 @default.
• W2556397922 cites W2043865741 @default.
• W2556397922 cites W2044843503 @default.
• W2556397922 cites W2046739515 @default.
• W2556397922 cites W2054723073 @default.
• W2556397922 cites W2055462844 @default.
• W2556397922 cites W2061279276 @default.
• W2556397922 cites W2063905144 @default.
• W2556397922 cites W2066150663 @default.
• W2556397922 cites W2066301717 @default.
• W2556397922 cites W2069820436 @default.
• W2556397922 cites W2082178034 @default.
• W2556397922 cites W2083944388 @default.
• W2556397922 cites W2084217329 @default.
• W2556397922 cites W2087484885 @default.
• W2556397922 cites W2090648462 @default.
• W2556397922 cites W2103110385 @default.
• W2556397922 cites W2107063140 @default.
• W2556397922 cites W2110976382 @default.
• W2556397922 cites W2113394015 @default.
• W2556397922 cites W2114056141 @default.
• W2556397922 cites W2116521814 @default.
• W2556397922 cites W2117306632 @default.
• W2556397922 cites W2118059649 @default.
• W2556397922 cites W2130583261 @default.
• W2556397922 cites W2131878646 @default.
• W2556397922 cites W2142269585 @default.
• W2556397922 cites W2145025818 @default.
• W2556397922 cites W2148728067 @default.
• W2556397922 cites W2148789836 @default.
• W2556397922 cites W2149694801 @default.
• W2556397922 cites W2157981718 @default.
• W2556397922 cites W2161633633 @default.
• W2556397922 cites W2162530578 @default.
• W2556397922 cites W2168377067 @default.
• W2556397922 cites W2207479656 @default.
• W2556397922 cites W2479735502 @default.
• W2556397922 cites W43490742 @default.
• W2556397922 doi "https://doi.org/10.1159/000452565" @default.
• W2556397922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27889765" @default.
• W2556397922 hasPublicationYear "2016" @default.
• W2556397922 type Work @default.
• W2556397922 sameAs 2556397922 @default.
• W2556397922 citedByCount "4" @default.
• W2556397922 countsByYear W25563979222017 @default.
• W2556397922 countsByYear W25563979222018 @default.
• W2556397922 countsByYear W25563979222019 @default.
• W2556397922 crossrefType "journal-article" @default.
• W2556397922 hasAuthorship W2556397922A5001081815 @default.
• W2556397922 hasAuthorship W2556397922A5003642180 @default.
• W2556397922 hasAuthorship W2556397922A5008147959 @default.
• W2556397922 hasAuthorship W2556397922A5018534905 @default.
• W2556397922 hasAuthorship W2556397922A5022523014 @default.
• W2556397922 hasAuthorship W2556397922A5030021123 @default.
• W2556397922 hasAuthorship W2556397922A5042241049 @default.
• W2556397922 hasAuthorship W2556397922A5043817596 @default.
• W2556397922 hasAuthorship W2556397922A5069980840 @default.
• W2556397922 hasBestOaLocation W25563979221 @default.
• W2556397922 hasConcept C104317684 @default.
• W2556397922 hasConcept C126322002 @default.
• W2556397922 hasConcept C135763542 @default.
• W2556397922 hasConcept C197754878 @default.
• W2556397922 hasConcept C2779134260 @default.
• W2556397922 hasConcept C54355233 @default.

• next