FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556434969> ?p ?o ?g. }

• W2556434969 abstract "Background HSP is one of the most common vasculitides of childhood. Glomerulonephritis is seen in approximately 30–50% of the patients and is the principal cause of morbidity and mortality in HSP patients. Objectives We describe our experience of managing children with HSP Nephritis (HSPN). Methods 314 children were registered in Pediatric Rheumatology Clinic, Advanced Pediatrics Centre, PGIMER, Chandigarh with a diagnosis of HSP based on EULAR/PRINTO/PRES criteria during the period from January 1993 to June 2015. A retrospective case review of all patients with HSPN with respect to clinical features, pathological findings and treatment was done. HSPN was defined based on urine erythrocyte >5/HPF and/or proteinuria >150mg/24 hr. Patients were divided into four clinical types according to the laboratory results: (1) isolated hematuria (urine erythrocyte >5/HPF and proteinuria (1) . Results Renal involvement was seen in 64 patients (20.4%) after a mean duration of 32.3 days from the onset of symptoms of HSP. Renal manifestations developed in 57.8% of the patients within 4 weeks of symptom onset, in 84.4% within 8 weeks and in 100% within 6 months. Massive proteinuria was the most common clinical feature seen in 56.7% of the patients followed by minimal proteinuria in 21.7%, moderate proteinuria in 15% and isolated hematuria in 6.7% of cases. Hypertension was seen in 24 patients. 4 patients had deranged renal function tests.13 patients developed a clinical relapse of the renal disease after a mean interval of 551.5 days from the remission of first episode. Albuminuria with microscopic hematuria was the most common presentation of second episode (77%) followed by isolated albuminuria (23%). Kidney biopsy was done in 48 patients. Three fourth of the patients had histological grade II or IIIa. 75% of patients with grade ≥ IV had gross hematuria at presentation. 25 patients received prednisolone alone, 31 received azathioprine in addition to prednisolone, while cyclophosphamide and mycophenolate mofetil were used in 5 and 1 patient respectively. Patients were followed up for a mean period of 3.6 years during which 13 were lost to follow up, 1 expired while 3 patients each are currently on prednisolone and azathioprine. Nephritis resolved in 48 patients (75%) with mean duration of renal involvement being more in patients with nephritis at presentation (429 days) as compared to patients who develop nephritis in follow up (321 days). Conclusions In our cohort of HSPN, 100% of the patients developed renal involvement within 6 months of the onset of symptoms of HSP with massive proteinuria being the most common clinical feature. Grade II and IIIa were the most common renal pathological grades seen in 75% of the patients. References Appel GB, Radhakrish J, D9Agati VD (2004) Secondary glomerular disease. In: Brenner BM (ed) The kidney, 7th edn. Saunders, Philadelphia, pp 1381–1482 Disclosure of Interest None declared" @default.
• W2556434969 created "2016-11-30" @default.
• W2556434969 creator A5000945265 @default.
• W2556434969 creator A5017984515 @default.
• W2556434969 creator A5019441772 @default.
• W2556434969 creator A5041534491 @default.
• W2556434969 creator A5057656661 @default.
• W2556434969 creator A5084921714 @default.
• W2556434969 creator A5086217092 @default.
• W2556434969 date "2016-06-01" @default.
• W2556434969 modified "2023-09-27" @default.
• W2556434969 title "AB0532 Profile of Henoch Schonlein Purpura (HSP) Nephritis: 23 Years Experience at A Tertiary Care Centre in North India" @default.
• W2556434969 doi "https://doi.org/10.1136/annrheumdis-2016-eular.4640" @default.
• W2556434969 hasPublicationYear "2016" @default.
• W2556434969 type Work @default.
• W2556434969 sameAs 2556434969 @default.
• W2556434969 citedByCount "0" @default.
• W2556434969 crossrefType "journal-article" @default.
• W2556434969 hasAuthorship W2556434969A5000945265 @default.
• W2556434969 hasAuthorship W2556434969A5017984515 @default.
• W2556434969 hasAuthorship W2556434969A5019441772 @default.
• W2556434969 hasAuthorship W2556434969A5041534491 @default.
• W2556434969 hasAuthorship W2556434969A5057656661 @default.
• W2556434969 hasAuthorship W2556434969A5084921714 @default.
• W2556434969 hasAuthorship W2556434969A5086217092 @default.
• W2556434969 hasConcept C126322002 @default.
• W2556434969 hasConcept C187212893 @default.
• W2556434969 hasConcept C18903297 @default.
• W2556434969 hasConcept C2777058396 @default.
• W2556434969 hasConcept C2777121669 @default.
• W2556434969 hasConcept C2779561371 @default.
• W2556434969 hasConcept C2780091579 @default.
• W2556434969 hasConcept C2780368995 @default.
• W2556434969 hasConcept C71924100 @default.
• W2556434969 hasConcept C86803240 @default.
• W2556434969 hasConcept C90924648 @default.
• W2556434969 hasConceptScore W2556434969C126322002 @default.
• W2556434969 hasConceptScore W2556434969C187212893 @default.
• W2556434969 hasConceptScore W2556434969C18903297 @default.
• W2556434969 hasConceptScore W2556434969C2777058396 @default.
• W2556434969 hasConceptScore W2556434969C2777121669 @default.
• W2556434969 hasConceptScore W2556434969C2779561371 @default.
• W2556434969 hasConceptScore W2556434969C2780091579 @default.
• W2556434969 hasConceptScore W2556434969C2780368995 @default.
• W2556434969 hasConceptScore W2556434969C71924100 @default.
• W2556434969 hasConceptScore W2556434969C86803240 @default.
• W2556434969 hasConceptScore W2556434969C90924648 @default.
• W2556434969 hasLocation W25564349691 @default.
• W2556434969 hasOpenAccess W2556434969 @default.
• W2556434969 hasPrimaryLocation W25564349691 @default.
• W2556434969 hasRelatedWork W1975855394 @default.
• W2556434969 hasRelatedWork W1997240977 @default.
• W2556434969 hasRelatedWork W2036562668 @default.
• W2556434969 hasRelatedWork W2059204103 @default.
• W2556434969 hasRelatedWork W229479741 @default.
• W2556434969 hasRelatedWork W2334059987 @default.
• W2556434969 hasRelatedWork W2352719073 @default.
• W2556434969 hasRelatedWork W2406489445 @default.
• W2556434969 hasRelatedWork W2413586323 @default.
• W2556434969 hasRelatedWork W2610802442 @default.
• W2556434969 hasRelatedWork W2754001392 @default.
• W2556434969 hasRelatedWork W2763285161 @default.
• W2556434969 hasRelatedWork W2783592427 @default.
• W2556434969 hasRelatedWork W2924381243 @default.
• W2556434969 hasRelatedWork W2974409787 @default.
• W2556434969 hasRelatedWork W3006672121 @default.
• W2556434969 hasRelatedWork W3030040395 @default.
• W2556434969 hasRelatedWork W3093642549 @default.
• W2556434969 hasRelatedWork W3165277273 @default.
• W2556434969 hasRelatedWork W83593718 @default.
• W2556434969 isParatext "false" @default.
• W2556434969 isRetracted "false" @default.
• W2556434969 magId "2556434969" @default.
• W2556434969 workType "article" @default.