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• W2556453407 abstract "Iminodipropionitrile, one of the nitrile derivatives induces neurotoxicity. The proposed mechanism postulated generation of free radicals and mitochondrial role in this process. It has been reported that ALA (Alpha lipoic acid) by the virtue of its antioxidant nature may prevent free radical induced neurotoxicity. The present study aimed at investigating the effects of Iminodipropionitrile (250mg/kg body weight) and Alpha lipoic acid (100mg/kg body weight) on the activities of TCA cycle enzymes ICDH (isocitrate dehydrogenase), SDH (succinate dehydrogenase), α-KDH (Alpha ketoglutarate dehydrogenase) and MDH (malate dehydrogenase) were found to be significantly reduced after Iminodipropionitrile administration. Subsequent treatment with ALA significantly alleviated the depletion in the level of these enzymes. The activities of ETC enzymes- NADH dehydrogenase and Cytochrome C oxidase were evaluated. Iminodipropionitrile administration significantly down regulated these activities whereas ALA restored the levels of these enzymes. It can be concluded that ALA effectively protects the hippocampal mitochondrial damage induced by Iminodipropionitrile." @default.
• W2556453407 created "2016-11-30" @default.
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• W2556453407 date "2011-01-01" @default.
• W2556453407 modified "2023-09-23" @default.
• W2556453407 title "Protective Effect of Alpha Lipoic Acid on Nitrile Induced Oxidative Destruction of ETC And TCA Cycle Enzymes in Rats Brain" @default.
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