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• W2556468480 abstract "Abstract Systemic sclerosis ( SS c) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies ( AFA ) in patients with SS c. The clinical features of 37 patients with SS c positive for AFA ( AFA +) and 139 SS c patients without AFA ( AFA −) were collected retrospectively from medical records to enable a comparison between AFA − and AFA + patients. Antifibrillarin autoantibodies were screened by an indirect immunofluorescence technique using HE p2 cells and identified by an in‐house Western blot technique and/or an EliA test. Comparing AFA + and AFA − patients, AFA + patients were significantly younger at disease onset (36.9 versus 42.9; P = 0.02), more frequently male ( P = 0.02) and of Afro‐Caribbean descent (65% versus 7.7%; P < 0.001). At diagnosis, the Rodnan skin score evaluating the cutaneous manifestations was higher (13.3 versus 8.7; P = 0.01) and myositis was also more common in the AFA + group (31.4% versus 12.2%; P < 0.01). Patients with AFA + were not associated with diffuse cutaneous SS c or with lung involvement and no difference in survival was observed. Antifibrillarin autoantibodies are associated with patients of Afro‐Caribbean origin and can identify patients with SS c who are younger at disease onset and display a higher prevalence of myositis." @default.
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• W2556468480 date "2017-01-01" @default.
• W2556468480 modified "2023-10-03" @default.
• W2556468480 title "The Clinical Relevance of Antifibrillarin (anti-U3-RNP) Autoantibodies in Systemic Sclerosis" @default.
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• W2556468480 doi "https://doi.org/10.1111/sji.12510" @default.
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