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- W2556547048 abstract "Background Chronic inflammation and some anti-inflammatory medications in rheumatoid arthritis (RA) are not only responsible for accelerated atherosclerosis but also have effects on the development of traditional risk factors, among which type 2 diabetes mellitus (DM) is the most important. Although hydroxychloroquine (HCQ) and TNF inhibitors have been reported to decrease incident DM risk in RA, there are still a number of unanswered questions regarding the impact of newer biologics, statins, and the timing, dosing, and sustainability of this effect. Objectives To investigate the impact of specific DMARDs and statins on the risk of incident DM in patients with RA. Methods Study patients were participants without baseline DM and at least 1 year in the National Data Bank for Rheumatic Diseases (NDB) from 2000 through 2015. DM was determined by patient self-report or use of DM-specific medication. Multivariable Cox proportional hazard models were adjusted for age, sex, ethnicity, socioeconomic and smoking status, comorbidities, body mass index (BMI), and RA severity while examining the time-dependent association of HCQ, other DMARDs, glucocorticoids (GC), and statins. Results During the 71,668 person-year followup of 13,669 RA patients, 1,139 developed DM. Adjusted HR (95% CI) for DM were 0.67 (0.57–0.80) for HCQ, 0.52 (0.31–0.89) for abatacept, 1.31 (1.15–1.49) for GC, and 1.56 (1.36–1.78) for statins (Table) . There was no evidence of risk change through MTX, other synthetic and biological DMARDs. Although the risk reduction was significantly associated with higher HCQ doses and longer (>4 years) treatment durations, HCQ dose of Conclusions The risk of incident DM in RA was reduced with HCQ and abatacept and increased with GC and statins. HCQ not only confers a sustainable, dose and treatment duration-dependent protective effect but also abolishes the increased risk of DM as a consequence of GC or statins. Disclosure of Interest None declared" @default.
- W2556547048 created "2016-11-30" @default.
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- W2556547048 date "2016-06-01" @default.
- W2556547048 modified "2023-10-02" @default.
- W2556547048 title "THU0082 Medication Impact on The Risk of Incident Diabetes Mellitus in Patients with Rheumatoid Arthritis: Hydroxychloroquine and Abatacept Protect while Glucocorticoids and Statins Worsen: Table 1." @default.
- W2556547048 doi "https://doi.org/10.1136/annrheumdis-2016-eular.4201" @default.
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