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• W2556620418 abstract "Background. A phase III multicenter open-label randomized comparative trial on antihypertensive efficacy and safety of fimasartan and losartan in parallel groups for adult outpatients with arterial hypertension (AH) 1–2 grade during 12 weeks of therapy was performed in 13 investigational sites of Russia. Design and methods. The study included patients with mean systolic blood pressure (SBP) in the sitting position ≥ 140 mm Hg and ≤ 179 mm Hg, previously treated patients underwent a «wash-out» period. The starting therapy was fimasartan 60 mg per day or losartan 50 mg per day, in case blood pressure was maintained at the level SBP ≥ 140 mm Hg and/or diastolic blood pressure (DBP) ≥ 90 mm Hg at 4 and 8 weeks of therapy the doses were increased up to 100 and 120 mg, respectively. Primary end-point was change from baseline in “office” sitting SBP at week 12 that was intended to show a “non-inferior” fimasartan efficiency (non-significant difference was set at 5,5 mm Hg). Results. Altogether 179 patients were randomized either to fimasartan (n = 89) or losartan (n = 90) groups. There were no differences between groups by demographic data and the characteristics of hypertension. After 12 weeks of treatment, mean SBP was 127,7 ± 8,0 mm Hg (–25,2 ± 8,6 mm Hg compared with baseline) in group fimasartan and 127,6 ± 5,6 mm Hg (–24,3 ± 7,8 mm Hg compared with baseline) in losartan group. The mean change in SBP was –0,18 ± 1,00 mm Hg (p = 0,390), the upper limit of the 95 % confidence interval was equal to 1,47 mm Hg that confirms the primary criterion of effectiveness. “Non-inferior” fimasartan efficiency was confirmed by the secondary criteria — the change in SBP and DBP at follow-up visits and the response rate. Safety profiles of fimasartan and losartan were comparable. Conclusions. Fimasartan is well tolerated, safe and provides similar to losartan BP lowering effect in outpatient population." @default.
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• W2556620418 date "2016-01-01" @default.
• W2556620418 modified "2023-09-25" @default.
• W2556620418 title "Efficacy and safety of fimasartan, a new angiotensin-receptor blocker, compared to losartan in mild-to-moderate hypertension" @default.
• W2556620418 doi "https://doi.org/10.18705/1607-419x-2016-22-2-204-216" @default.
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