FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556648357> ?p ?o ?g. }

• W2556648357 endingPage "160230" @default.
• W2556648357 startingPage "160230" @default.
• W2556648357 abstract "RANK and RANKL, a receptor ligand pair belonging to the tumour necrosis factor family, are the critical regulators of osteoclast development and bone metabolism. Besides their essential function in bone, RANK and RANKL have also been identified as the key factors for the formation of a lactating mammary gland in pregnancy. Mechanistically, RANK and RANKL link the sex hormone progesterone with stem cell expansion and proliferation of mammary epithelial cells. Based on their normal physiology, RANKL/RANK control the onset of hormone-induced breast cancer through the expansion of mammary progenitor cells. Recently, we and others were able to show that RANK and RANKL are also critical regulators of BRCA1 -mutation-driven breast cancer. Currently, the preventive strategy for BRCA1 -mutation carriers includes preventive mastectomy, associated with wide-ranging risks and psychosocial effects. The search for an alternative non-invasive prevention strategy is therefore of paramount importance. As our work strongly implicates RANK and RANKL as key molecules involved in the initiation of BRCA1-associated breast cancer, we propose that anti-RANKL therapy could be a feasible preventive strategy for women carrying BRCA1 mutations, and by extension to other women with high risk of breast cancer." @default.
• W2556648357 created "2016-11-30" @default.
• W2556648357 creator A5030889614 @default.
• W2556648357 creator A5053226783 @default.
• W2556648357 creator A5059310975 @default.
• W2556648357 date "2016-11-01" @default.
• W2556648357 modified "2023-10-13" @default.
• W2556648357 title "RANKL/RANK: from bone loss to the prevention of breast cancer" @default.
• W2556648357 cites W1506203929 @default.
• W2556648357 cites W1534645474 @default.
• W2556648357 cites W1545950342 @default.
• W2556648357 cites W1593442063 @default.
• W2556648357 cites W1650001464 @default.
• W2556648357 cites W1677043489 @default.
• W2556648357 cites W1725742191 @default.
• W2556648357 cites W1897016067 @default.
• W2556648357 cites W1971949613 @default.
• W2556648357 cites W1973683234 @default.
• W2556648357 cites W1974140746 @default.
• W2556648357 cites W1976117245 @default.
• W2556648357 cites W1977872674 @default.
• W2556648357 cites W1979440527 @default.
• W2556648357 cites W1984431444 @default.
• W2556648357 cites W1984433201 @default.
• W2556648357 cites W1985099245 @default.
• W2556648357 cites W1987276398 @default.
• W2556648357 cites W2000647744 @default.
• W2556648357 cites W2010571055 @default.
• W2556648357 cites W2011515749 @default.
• W2556648357 cites W2013609305 @default.
• W2556648357 cites W2015005969 @default.
• W2556648357 cites W2023398724 @default.
• W2556648357 cites W2026889273 @default.
• W2556648357 cites W2029151927 @default.
• W2556648357 cites W2036368043 @default.
• W2556648357 cites W2045733577 @default.
• W2556648357 cites W2045995534 @default.
• W2556648357 cites W2051320963 @default.
• W2556648357 cites W2057275651 @default.
• W2556648357 cites W2063169494 @default.
• W2556648357 cites W2064917274 @default.
• W2556648357 cites W2068476548 @default.
• W2556648357 cites W2080951756 @default.
• W2556648357 cites W2083339409 @default.
• W2556648357 cites W2085872402 @default.
• W2556648357 cites W2087025655 @default.
• W2556648357 cites W2096027508 @default.
• W2556648357 cites W2100217829 @default.
• W2556648357 cites W2101774988 @default.
• W2556648357 cites W2101791074 @default.
• W2556648357 cites W2112078646 @default.
• W2556648357 cites W2114027903 @default.
• W2556648357 cites W2117963341 @default.
• W2556648357 cites W2122786185 @default.
• W2556648357 cites W2123347329 @default.
• W2556648357 cites W2124105940 @default.
• W2556648357 cites W2125679885 @default.
• W2556648357 cites W2130277199 @default.
• W2556648357 cites W2130891215 @default.
• W2556648357 cites W2133197305 @default.
• W2556648357 cites W2133670454 @default.
• W2556648357 cites W2134539328 @default.
• W2556648357 cites W2134565188 @default.
• W2556648357 cites W2137830201 @default.
• W2556648357 cites W2145245207 @default.
• W2556648357 cites W2148227665 @default.
• W2556648357 cites W2149597080 @default.
• W2556648357 cites W2153051750 @default.
• W2556648357 cites W2153579158 @default.
• W2556648357 cites W2153864725 @default.
• W2556648357 cites W2164699140 @default.
• W2556648357 cites W2165413853 @default.
• W2556648357 cites W2166247816 @default.
• W2556648357 cites W2168523417 @default.
• W2556648357 cites W2170384111 @default.
• W2556648357 cites W2269179103 @default.
• W2556648357 cites W2330722106 @default.
• W2556648357 cites W2410239982 @default.
• W2556648357 cites W2414274468 @default.
• W2556648357 cites W2470543765 @default.
• W2556648357 cites W2515721699 @default.
• W2556648357 cites W3140406626 @default.
• W2556648357 cites W3170143802 @default.
• W2556648357 cites W48270215 @default.
• W2556648357 doi "https://doi.org/10.1098/rsob.160230" @default.
• W2556648357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133443" @default.
• W2556648357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27881737" @default.
• W2556648357 hasPublicationYear "2016" @default.
• W2556648357 type Work @default.
• W2556648357 sameAs 2556648357 @default.
• W2556648357 citedByCount "49" @default.
• W2556648357 countsByYear W25566483572017 @default.
• W2556648357 countsByYear W25566483572018 @default.
• W2556648357 countsByYear W25566483572019 @default.
• W2556648357 countsByYear W25566483572020 @default.
• W2556648357 countsByYear W25566483572021 @default.
• W2556648357 countsByYear W25566483572022 @default.
• W2556648357 countsByYear W25566483572023 @default.

• next