FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556691407> ?p ?o ?g. }

• W2556691407 endingPage "1549" @default.
• W2556691407 startingPage "1549" @default.
• W2556691407 abstract "Nanostructured lipid carriers (NLC) exhibit high skin targeting efficiency and good safety. They are promising vehicles for topical drug delivery. This study aims to increase the skin distribution of podophyllotoxin (POD) by incorporating it into NLCs. Two kinds of POD-loaded NLCs (POD-NLCs)-POD-NLCformulation 1 and POD-NLCformulation 2-were prepared and characterized. Their skin targeting efficiencies were compared by conducting in vitro and in vivo experiments. Obviously smaller mean particle size was observed for POD-NLCformulation 1 (106 nm) than POD-NLCformulation 2 (219 nm), whereas relatively low POD loadings (less than 0.5%) were observed for both POD-NLCformulation 1 (0.33%) and POD-NLCformulation 2 (0.49%). Significantly higher in vitro and in vivo rat skin deposit amounts of POD (p ˂ 0.01) were detected after the topical application of POD-NLCformulation 1 compared to POD-NLCformulation 2. To visualize the skin distribution behavior of hydrophobic active pharmaceutical ingredients (APIs) when NLCs were used as carriers, POD was replaced with Nile red (NR-a hydrophobic fluorescent probe), and the distribution behavior of NR-NLCformulation 1 and NR-NLCformulation 2 in rat skin in vivo was observed using confocal laser scanning microscopy (CLSM). Higher fluorescent intensity was observed in rat skin after the topical application of NR-NLCformulation 1 than NR-NLCformulation 2, suggesting that higher skin targeting efficiency might be obtained when NLCs with smaller mean particle size were used as carriers for hydrophobic APIs. This result was in accordance with those of skin distribution evaluation experiments of POD-NLCs. Skin irritation property of POD-NLCformulation 1 was investigated and no irritation was observed in intact or damaged rabbit skin, suggesting it is safe for topical use. Our results validated the safety of NLCs when applied topically. More importantly, mean particle size might be an important parameter for formulation optimization when NLCs are used as carriers for hydrophobic APIs for topical application, considering that their loading is relatively low." @default.
• W2556691407 created "2016-11-30" @default.
• W2556691407 creator A5000281620 @default.
• W2556691407 creator A5015749495 @default.
• W2556691407 creator A5030978002 @default.
• W2556691407 creator A5033935529 @default.
• W2556691407 creator A5074014325 @default.
• W2556691407 creator A5089113644 @default.
• W2556691407 date "2016-11-17" @default.
• W2556691407 modified "2023-10-16" @default.
• W2556691407 title "Podophyllotoxin-Loaded Nanostructured Lipid Carriers for Skin Targeting: In Vitro and In Vivo Studies" @default.
• W2556691407 cites W1964843466 @default.
• W2556691407 cites W1976336238 @default.
• W2556691407 cites W1976779766 @default.
• W2556691407 cites W1985227672 @default.
• W2556691407 cites W1987433127 @default.
• W2556691407 cites W1993030074 @default.
• W2556691407 cites W1999106349 @default.
• W2556691407 cites W2019355258 @default.
• W2556691407 cites W2019534962 @default.
• W2556691407 cites W2022154646 @default.
• W2556691407 cites W2024390368 @default.
• W2556691407 cites W2026012172 @default.
• W2556691407 cites W2028761028 @default.
• W2556691407 cites W2030747032 @default.
• W2556691407 cites W2036334093 @default.
• W2556691407 cites W2040221200 @default.
• W2556691407 cites W2040685164 @default.
• W2556691407 cites W2041986910 @default.
• W2556691407 cites W2047397273 @default.
• W2556691407 cites W2053002347 @default.
• W2556691407 cites W2054189154 @default.
• W2556691407 cites W2054435240 @default.
• W2556691407 cites W2056764794 @default.
• W2556691407 cites W2059210146 @default.
• W2556691407 cites W2062541378 @default.
• W2556691407 cites W2062652730 @default.
• W2556691407 cites W2065870072 @default.
• W2556691407 cites W2073224593 @default.
• W2556691407 cites W2077050915 @default.
• W2556691407 cites W2081198469 @default.
• W2556691407 cites W2090824151 @default.
• W2556691407 cites W2116434150 @default.
• W2556691407 cites W2137902073 @default.
• W2556691407 cites W2141162588 @default.
• W2556691407 cites W2164408224 @default.
• W2556691407 cites W2166458266 @default.
• W2556691407 cites W4238116568 @default.
• W2556691407 cites W4383740241 @default.
• W2556691407 cites W87444228 @default.
• W2556691407 doi "https://doi.org/10.3390/molecules21111549" @default.
• W2556691407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6274358" @default.
• W2556691407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27869698" @default.
• W2556691407 hasPublicationYear "2016" @default.
• W2556691407 type Work @default.
• W2556691407 sameAs 2556691407 @default.
• W2556691407 citedByCount "25" @default.
• W2556691407 countsByYear W25566914072016 @default.
• W2556691407 countsByYear W25566914072017 @default.
• W2556691407 countsByYear W25566914072018 @default.
• W2556691407 countsByYear W25566914072019 @default.
• W2556691407 countsByYear W25566914072020 @default.
• W2556691407 countsByYear W25566914072021 @default.
• W2556691407 countsByYear W25566914072022 @default.
• W2556691407 countsByYear W25566914072023 @default.
• W2556691407 crossrefType "journal-article" @default.
• W2556691407 hasAuthorship W2556691407A5000281620 @default.
• W2556691407 hasAuthorship W2556691407A5015749495 @default.
• W2556691407 hasAuthorship W2556691407A5030978002 @default.
• W2556691407 hasAuthorship W2556691407A5033935529 @default.
• W2556691407 hasAuthorship W2556691407A5074014325 @default.
• W2556691407 hasAuthorship W2556691407A5089113644 @default.
• W2556691407 hasBestOaLocation W25566914071 @default.
• W2556691407 hasConcept C110121322 @default.
• W2556691407 hasConcept C121332964 @default.
• W2556691407 hasConcept C12554922 @default.
• W2556691407 hasConcept C134306372 @default.
• W2556691407 hasConcept C136229726 @default.
• W2556691407 hasConcept C137776501 @default.
• W2556691407 hasConcept C147789679 @default.
• W2556691407 hasConcept C150903083 @default.
• W2556691407 hasConcept C155672457 @default.
• W2556691407 hasConcept C171250308 @default.
• W2556691407 hasConcept C185592680 @default.
• W2556691407 hasConcept C187530423 @default.
• W2556691407 hasConcept C192562407 @default.
• W2556691407 hasConcept C202751555 @default.
• W2556691407 hasConcept C207001950 @default.
• W2556691407 hasConcept C2777459323 @default.
• W2556691407 hasConcept C2778086801 @default.
• W2556691407 hasConcept C2778143360 @default.
• W2556691407 hasConcept C33923547 @default.
• W2556691407 hasConcept C54355233 @default.
• W2556691407 hasConcept C55493867 @default.
• W2556691407 hasConcept C59822182 @default.
• W2556691407 hasConcept C62520636 @default.
• W2556691407 hasConcept C71240020 @default.
• W2556691407 hasConcept C71924100 @default.

• next