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- W2556732272 abstract "This work describes the total synthesis of the alkaloid cenocladamide and a concise library of nine structural analogues aiming at their evaluation against the breast cancer cell line MDA-MB-231. The most promising compound (3; IC50 = 6.6 μM) was also evaluated in a panel of seven breast cancer cell lines and two non-tumorigenic cell lines. We further conducted an initial investigation on the mechanism of action of analogue 3, which lacks the endocyclic double bond when compared to cenocladamide. The present study presents the discovery of a cenocladamide analogue with interesting cytotoxic activity, which could be useful for further optimization towards new chemotherapeutic agents for breast cancer treatment." @default.
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- W2556732272 date "2017-01-01" @default.
- W2556732272 modified "2023-10-18" @default.
- W2556732272 title "Design and synthesis of cenocladamide analogues and their evaluation against breast cancer cell lines" @default.
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- W2556732272 doi "https://doi.org/10.1039/c6md00577b" @default.
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