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- W2556803721 abstract "COPD is characterised by chronic inflammation which is predominantly neutrophilic, but is eosinophilic in 10-40% of cases. Whether clinical features of COPD including an airway predominant versus emphysema phenotype are different between eosinophilic and non-eosinophilic COPD is unclear. The EvA consortium recruited 458 subjects of which 412 had an assessable quantitative computed tomography (qCT) to determine lung density (Perc15Hu) and wall area % (WA%) of the apical segment of the right upper lobe. Other investigations conducted included lung function tests, blood and sputum samples, which were assessable in 256 subjects. The subjects were dichotomised into two groups using clinically important cut-offs for blood eosinophils (≥ 200 cells/mL; N=188) and percentage eosinophils in sputum (≥3%; N=111). There were no significant differences between those subjects with or without eosinophilic COPD with respect to demographics, spirometry, lung volumes or diffusion. Total serum IgE was correlated with blood eosinophil counts (rs=0.233; p In conclusion, eosinophilic and non-eosinophilic COPD have similar clinical and physiological characteristics and cannot be distinguished by qCT-derived measures of emphysema or airway remodelling." @default.
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- W2556803721 date "2016-09-01" @default.
- W2556803721 modified "2023-09-27" @default.
- W2556803721 title "Eosinophilic versus non-eosinophilic COPD cannot be distinguished by lung function nor CT determined emphysema or airway remodelling" @default.
- W2556803721 doi "https://doi.org/10.1183/13993003.congress-2016.pa4623" @default.
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