Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556812977> ?p ?o ?g. }
- W2556812977 endingPage "244" @default.
- W2556812977 startingPage "235" @default.
- W2556812977 abstract "There is an accumulating evidence suggesting an immunomodulatory role of 1α,25(OH)2D3. Altered 1α,25(OH)2D3 level may play a role in the development of T2DM and contribute to the pathogenesis of liver diseases. Our study was designed to study and compare the effect of metformin and 1α,25(OH)2D3 supplementation on liver injury in type 2 diabetic rat. Sixty male Albino rats were divided into 5 groups; group 1: control rats. the remaining rats were fed high fat diet for 2 weeks and injected with streptozotocin (35mg/kg BW, i.p.) to induce T2DM and were divided into: group 2: untreated diabetic rats, group 3: diabetic rats treated by metformin (100mg/kgBW/d, orally), group 4: diabetic rats supplemented by 1α,25(OH)2D3 (0.5μg/kg BW, i.p.) 3 times weekly and group 5: supplemented by both 1α,25(OH)2D3 and metformin. Eight weeks later, serum glucose and insulin levels were measured, HOMA IR was calculated, lipid profile, Ca2+, ALT and AST were estimated. Liver specimens were taken to investigate PPAR-α (regulator of lipid metabolism), NF-κB p65, caspase 3 and PCNA (proliferating cell nuclear antigen) and for histological examination. The liver enzymes were elevated in the diabetic rats and the histological results revealed an injurious effect of diabetes on the liver. 1α,25(OH)2D3, metformin and both drugs treatment significantly improved liver enzymes as compared to the untreated rats. The improvement was associated with a significant improvement in the glycemic control, lipid profile and serum Ca2+ with a significant reduction in NF-κB p65 and caspase 3 and increased PPAR-α, and PCNA expression as compared to the untreated group. 1α,25(OH)2D3 induced a slightly better effect as compared to metformin. Both agents together had a synergistic action and almost completely protected the liver. Histological results confirmed the biochemical findings. Our results showed a protective effect of 1α,25(OH)2D3 and metformin on liver in diabetic rats as indicated by an improvement of the level of the liver enzymes, decreased apoptosis and increased proliferation and this was confirmed histologically, with modulating NFkB and PPAR-α. Both agents together had a synergistic effect." @default.
- W2556812977 created "2016-11-30" @default.
- W2556812977 creator A5006220103 @default.
- W2556812977 creator A5016435576 @default.
- W2556812977 creator A5025439569 @default.
- W2556812977 creator A5027715706 @default.
- W2556812977 creator A5070632684 @default.
- W2556812977 date "2017-10-01" @default.
- W2556812977 modified "2023-09-25" @default.
- W2556812977 title "The protective effect of 1alpha, 25-dihydroxyvitamin d3 and metformin on liver in type 2 diabetic rats" @default.
- W2556812977 cites W185214937 @default.
- W2556812977 cites W187304924 @default.
- W2556812977 cites W1969750765 @default.
- W2556812977 cites W1973127006 @default.
- W2556812977 cites W1977549443 @default.
- W2556812977 cites W1978277179 @default.
- W2556812977 cites W1978380407 @default.
- W2556812977 cites W1981084145 @default.
- W2556812977 cites W1998948324 @default.
- W2556812977 cites W2001402616 @default.
- W2556812977 cites W2001563682 @default.
- W2556812977 cites W2005177004 @default.
- W2556812977 cites W2005806641 @default.
- W2556812977 cites W2005832736 @default.
- W2556812977 cites W2010972666 @default.
- W2556812977 cites W2013570209 @default.
- W2556812977 cites W2015569637 @default.
- W2556812977 cites W2018669479 @default.
- W2556812977 cites W2019980875 @default.
- W2556812977 cites W2024693050 @default.
- W2556812977 cites W2026437158 @default.
- W2556812977 cites W2029625589 @default.
- W2556812977 cites W2029631602 @default.
- W2556812977 cites W2029820081 @default.
- W2556812977 cites W2039963918 @default.
- W2556812977 cites W2040324906 @default.
- W2556812977 cites W2049629344 @default.
- W2556812977 cites W2057522312 @default.
- W2556812977 cites W2059743234 @default.
- W2556812977 cites W2073882423 @default.
- W2556812977 cites W2077716285 @default.
- W2556812977 cites W2081621440 @default.
- W2556812977 cites W2083884524 @default.
- W2556812977 cites W2087011218 @default.
- W2556812977 cites W2093462070 @default.
- W2556812977 cites W2096352766 @default.
- W2556812977 cites W2099479777 @default.
- W2556812977 cites W2103563428 @default.
- W2556812977 cites W2108244474 @default.
- W2556812977 cites W2118233442 @default.
- W2556812977 cites W2118256039 @default.
- W2556812977 cites W2123472586 @default.
- W2556812977 cites W2126295203 @default.
- W2556812977 cites W2129262141 @default.
- W2556812977 cites W2134615583 @default.
- W2556812977 cites W2136581059 @default.
- W2556812977 cites W2140937253 @default.
- W2556812977 cites W2142105417 @default.
- W2556812977 cites W2144378498 @default.
- W2556812977 cites W2149602039 @default.
- W2556812977 cites W2151595660 @default.
- W2556812977 cites W2152510629 @default.
- W2556812977 cites W2154344345 @default.
- W2556812977 cites W2156107814 @default.
- W2556812977 cites W2159581380 @default.
- W2556812977 cites W2160234571 @default.
- W2556812977 cites W2160240772 @default.
- W2556812977 cites W2162611634 @default.
- W2556812977 cites W2171987230 @default.
- W2556812977 cites W2284131665 @default.
- W2556812977 cites W2415492625 @default.
- W2556812977 cites W4230768214 @default.
- W2556812977 cites W959837056 @default.
- W2556812977 doi "https://doi.org/10.1016/j.jsbmb.2016.11.012" @default.
- W2556812977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27876536" @default.
- W2556812977 hasPublicationYear "2017" @default.
- W2556812977 type Work @default.
- W2556812977 sameAs 2556812977 @default.
- W2556812977 citedByCount "12" @default.
- W2556812977 countsByYear W25568129772017 @default.
- W2556812977 countsByYear W25568129772018 @default.
- W2556812977 countsByYear W25568129772019 @default.
- W2556812977 countsByYear W25568129772020 @default.
- W2556812977 countsByYear W25568129772021 @default.
- W2556812977 countsByYear W25568129772022 @default.
- W2556812977 crossrefType "journal-article" @default.
- W2556812977 hasAuthorship W2556812977A5006220103 @default.
- W2556812977 hasAuthorship W2556812977A5016435576 @default.
- W2556812977 hasAuthorship W2556812977A5025439569 @default.
- W2556812977 hasAuthorship W2556812977A5027715706 @default.
- W2556812977 hasAuthorship W2556812977A5070632684 @default.
- W2556812977 hasConcept C126322002 @default.
- W2556812977 hasConcept C134018914 @default.
- W2556812977 hasConcept C204232928 @default.
- W2556812977 hasConcept C2776637226 @default.
- W2556812977 hasConcept C2777180221 @default.
- W2556812977 hasConcept C2778384471 @default.
- W2556812977 hasConcept C2778772119 @default.