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• W2556853526 abstract "L-Ornithine plays an important role in metabolism. Ornithine in addition to arginine and citrulline is involved in the (Krebs) ornithine cycle, a cyclic enzymatic process of sequential transformations leading to the deactivation and elimination of toxic ammonia and urea synthesis in vivo in humans, animals, and also certain plant and microorganism species. L-Ornithine L-aspartate is the salt of L-aspartic acid and L-ornithine that is used as the substance for manufacturing the hepatoprotective drugs Hepatil (Poland) and Hepa-Merz (Germany). They are used to reduce the ammonia level in vivo upon manifestation of hepatic insufficiency. Liver diseases are very common among the population of developed countries. This is related to increased alcohol consumption, poor diet, diabetes mellitus, and the use of toxic medicines for treatment of certain diseases and is also a consequence of transmitted viral hepatitis. L-Ornithine base, which has limited stability, must be used to prepare L-ornithine L-aspartate. In industry, L-ornithine is prepared by enzymatic synthesis via the action of arginase on L-arginine or L-glutamic acid. For this, L-ornithine is usually isolated as the more stable sulfate or chloride salts. These salts are processed beforehand on strong-acid cation-exchange resins in order to isolate L-ornithine base, which is necessary for manufacture of the substance [1 – 3]. These processes are lengthy and costly. The problem of developing simple routes to L-ornithine through classical synthetic organic methods remains critical, despite biotechnology successes in the manufacture of this amino acid. Studies in which citrulline and ornithine were prepared via basic hydrolysis of arginine were reported [4, 5]. It was found that the hydrolysis occurred with the formation of racemic products if strong bases were used. The preparation of L-ornithine hydrochloride via basic hydrolysis of L-arginine hydrochloride using Ba(OH) 2 was described [5]. The barium cations were precipitated at the end of the process by adding H 2 SO 4 . The product was isolated as L-ornithine hydrochloride mixed with citrulline. The goal of the present work was to develop a simple method for preparing L-ornithine L-aspartate from L-arginine subjected to basic hydrolysis. A chemical scheme according to which L-ornithine L-aspartate was prepared in three main steps was developed: 1. Hydrolysis of L-arginine to form L-citrulline and conversion of it to L-ornithine via coupled deamination and decarboxylation reactions." @default.
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• W2556853526 date "2012-01-01" @default.
• W2556853526 modified "2023-09-26" @default.
• W2556853526 title "DRUG SYNTHESIS METHODS AND PRODUCTION TECHNOLOGY SYNTHESIS OF L-ORNITHINE L-ASPARTATE FROM L-ARGININE" @default.
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