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• W2556936397 abstract "Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant (MDR) Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread. Co-localization of the mcr-1 gene and Extended-Spectrum- β-lactamase (ESBL) genes on a unique plasmid has been also identified in many isolates from animal origin. The use of colistin in pigs as a growth promoter and for prophylaxis purposes should be banned, and the implantation of sustainable measures in pig farms for microbial infection prevention should be actively encouraged and financed. The scientific research should be encouraged in swine medicine to generate data helping to reduce the exacerbation of colistin resistance in pigs and in manure. The establishment of guidelines ensuring a judicious therapeutic use of colistin in pigs, in countries where this drug is approved, is of crucial importance. The implementation of a microbiological withdrawal period that could reduce the potential contamination of consumers with colistin resistant bacteria of porcine origin should be encouraged. Moreover, the management of colistin resistance at the human-pig-environment interface requires the urgent use of the One Health approach for effective control and prevention. This approach needs the collaborative effort of multiple disciplines and close cooperation between physicians, veterinarians, and other scientific health and environmental professionals. This review is an update on the chemistry of colistin, its applications and antibacterial mechanism of action, and on Enterobacteriaceae resistance to colistin in pigs. We also detail and discuss the One Health approach and propose guidelines for colistin resistance management." @default.
• W2556936397 created "2016-11-30" @default.
• W2556936397 creator A5002807478 @default.
• W2556936397 creator A5019239240 @default.
• W2556936397 creator A5049788459 @default.
• W2556936397 creator A5088746087 @default.
• W2556936397 date "2016-11-11" @default.
• W2556936397 modified "2023-10-11" @default.
• W2556936397 title "Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives" @default.
• W2556936397 cites W1458969888 @default.
• W2556936397 cites W1608504359 @default.
• W2556936397 cites W1650275048 @default.
• W2556936397 cites W1758417497 @default.
• W2556936397 cites W1911946138 @default.
• W2556936397 cites W1949509034 @default.
• W2556936397 cites W1967346383 @default.
• W2556936397 cites W1972012249 @default.
• W2556936397 cites W1972175795 @default.
• W2556936397 cites W1973383468 @default.
• W2556936397 cites W1974062140 @default.
• W2556936397 cites W1975476266 @default.
• W2556936397 cites W1977276238 @default.
• W2556936397 cites W1978379449 @default.
• W2556936397 cites W1980863376 @default.
• W2556936397 cites W1982126669 @default.
• W2556936397 cites W1982374652 @default.
• W2556936397 cites W1982760680 @default.
• W2556936397 cites W1984177866 @default.
• W2556936397 cites W1986134918 @default.
• W2556936397 cites W1988595672 @default.
• W2556936397 cites W1991283403 @default.
• W2556936397 cites W1991623431 @default.
• W2556936397 cites W1992995635 @default.
• W2556936397 cites W1993287556 @default.
• W2556936397 cites W1997329807 @default.
• W2556936397 cites W1997406633 @default.
• W2556936397 cites W1999935229 @default.
• W2556936397 cites W2000738120 @default.
• W2556936397 cites W2003602856 @default.
• W2556936397 cites W2004047381 @default.
• W2556936397 cites W2004918900 @default.
• W2556936397 cites W2011044047 @default.
• W2556936397 cites W2014195893 @default.
• W2556936397 cites W2016572586 @default.
• W2556936397 cites W2018497468 @default.
• W2556936397 cites W2021980258 @default.
• W2556936397 cites W2023733349 @default.
• W2556936397 cites W2024616331 @default.
• W2556936397 cites W2026917976 @default.
• W2556936397 cites W2035474027 @default.
• W2556936397 cites W2036169157 @default.
• W2556936397 cites W2037887534 @default.
• W2556936397 cites W2044813508 @default.
• W2556936397 cites W2047148196 @default.
• W2556936397 cites W2047618274 @default.
• W2556936397 cites W2047661734 @default.
• W2556936397 cites W2051101891 @default.
• W2556936397 cites W2052643143 @default.
• W2556936397 cites W2053115337 @default.
• W2556936397 cites W2055457066 @default.
• W2556936397 cites W2061202063 @default.
• W2556936397 cites W2064450906 @default.
• W2556936397 cites W2064668487 @default.
• W2556936397 cites W2064968987 @default.
• W2556936397 cites W2066560470 @default.
• W2556936397 cites W2068434462 @default.
• W2556936397 cites W2068950869 @default.
• W2556936397 cites W2070416464 @default.
• W2556936397 cites W2071360166 @default.
• W2556936397 cites W2073075704 @default.
• W2556936397 cites W2073556554 @default.
• W2556936397 cites W2074594048 @default.
• W2556936397 cites W2076254253 @default.
• W2556936397 cites W2076639843 @default.
• W2556936397 cites W2085136523 @default.
• W2556936397 cites W2088112817 @default.
• W2556936397 cites W2090456048 @default.
• W2556936397 cites W2090678979 @default.
• W2556936397 cites W2091488830 @default.
• W2556936397 cites W2094720560 @default.
• W2556936397 cites W2096148345 @default.
• W2556936397 cites W2096250787 @default.
• W2556936397 cites W2098862667 @default.
• W2556936397 cites W2106925795 @default.
• W2556936397 cites W2107179810 @default.
• W2556936397 cites W2107183457 @default.
• W2556936397 cites W2109071628 @default.
• W2556936397 cites W2111696003 @default.
• W2556936397 cites W2115564116 @default.
• W2556936397 cites W2116218816 @default.
• W2556936397 cites W2116245384 @default.
• W2556936397 cites W2117464052 @default.
• W2556936397 cites W2117795567 @default.
• W2556936397 cites W2118432031 @default.
• W2556936397 cites W2122863984 @default.
• W2556936397 cites W2123135656 @default.
• W2556936397 cites W2125578816 @default.
• W2556936397 cites W2125893214 @default.
• W2556936397 cites W2129371955 @default.
• W2556936397 cites W2130224428 @default.

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