FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556971034> ?p ?o ?g. }

• W2556971034 endingPage "777" @default.
• W2556971034 startingPage "766" @default.
• W2556971034 abstract "Fibroblast growth factor receptor 4 (FGFR4) plays an important role in cancer progression during tumor proliferation, invasion, and metastasis. This study evaluated the prognostic role of FGFR4 polymorphism in patients with resected colon cancer, including the underlying mechanism.FGFR4 polymorphism was characterized in patientswho received curative resection for stage III colon cancer. FGFR4-dependent signal pathways involving cell proliferation, invasion, and migration according to genotypes were also evaluated in transfected colon cancer cell lines.Among a total of 273 patients, the GG of FGFR4 showed significantly better overall survival than the AG or AA, regardless of adjuvant treatment. In the group of AG or AA, combination of folinic acid, fluorouracil, and oxaliplatin (FOLFOX) resulted in better survival than fluorouracil/leucovorin or no adjuvant chemotherapy. However, in GG, there was no difference among treatment regimens. Using multivariate analyses, the Arg388 carriers, together with age, N stage, poor differentiation, absence of a lymphocyte response, and no adjuvant chemotherapy, had a significantly worse OS than patients with the Gly388 allele. In transfected colon cancer cells, overexpression of Arg388 significantly increased cell proliferation and changes in epithelial to mesenchymal transition markers compared with cells overexpressing the Gly388 allele.The Arg388 allele of FGFR4 may be a biomarker and a candidate target for adjuvant treatment of patients with resected colon cancer." @default.
• W2556971034 created "2016-11-30" @default.
• W2556971034 creator A5001179320 @default.
• W2556971034 creator A5003518828 @default.
• W2556971034 creator A5010897635 @default.
• W2556971034 creator A5030104968 @default.
• W2556971034 creator A5052958094 @default.
• W2556971034 creator A5068056974 @default.
• W2556971034 creator A5075280017 @default.
• W2556971034 creator A5081254876 @default.
• W2556971034 creator A5089277539 @default.
• W2556971034 date "2017-07-15" @default.
• W2556971034 modified "2023-10-12" @default.
• W2556971034 title "FGFR4 Arg388 Is Correlated with Poor Survival in Resected Colon Cancer Promoting Epithelial to Mesenchymal Transition" @default.
• W2556971034 cites W1703297995 @default.
• W2556971034 cites W1858086881 @default.
• W2556971034 cites W1973116775 @default.
• W2556971034 cites W1988476050 @default.
• W2556971034 cites W2019711215 @default.
• W2556971034 cites W2044317336 @default.
• W2556971034 cites W2063283864 @default.
• W2556971034 cites W2063746351 @default.
• W2556971034 cites W2066581195 @default.
• W2556971034 cites W2077462602 @default.
• W2556971034 cites W2077673213 @default.
• W2556971034 cites W2096258722 @default.
• W2556971034 cites W2097325167 @default.
• W2556971034 cites W2098466520 @default.
• W2556971034 cites W2106465830 @default.
• W2556971034 cites W2108353976 @default.
• W2556971034 cites W2108517817 @default.
• W2556971034 cites W2113113178 @default.
• W2556971034 cites W2121214880 @default.
• W2556971034 cites W2130787560 @default.
• W2556971034 cites W2133054656 @default.
• W2556971034 cites W2142702787 @default.
• W2556971034 cites W2148388780 @default.
• W2556971034 cites W2152704304 @default.
• W2556971034 cites W2161916041 @default.
• W2556971034 cites W2169752008 @default.
• W2556971034 cites W2170056461 @default.
• W2556971034 cites W2175412058 @default.
• W2556971034 cites W2221464277 @default.
• W2556971034 cites W2409987903 @default.
• W2556971034 doi "https://doi.org/10.4143/crt.2016.457" @default.
• W2556971034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5512371" @default.
• W2556971034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27857023" @default.
• W2556971034 hasPublicationYear "2017" @default.
• W2556971034 type Work @default.
• W2556971034 sameAs 2556971034 @default.
• W2556971034 citedByCount "12" @default.
• W2556971034 countsByYear W25569710342018 @default.
• W2556971034 countsByYear W25569710342019 @default.
• W2556971034 countsByYear W25569710342020 @default.
• W2556971034 countsByYear W25569710342021 @default.
• W2556971034 countsByYear W25569710342022 @default.
• W2556971034 crossrefType "journal-article" @default.
• W2556971034 hasAuthorship W2556971034A5001179320 @default.
• W2556971034 hasAuthorship W2556971034A5003518828 @default.
• W2556971034 hasAuthorship W2556971034A5010897635 @default.
• W2556971034 hasAuthorship W2556971034A5030104968 @default.
• W2556971034 hasAuthorship W2556971034A5052958094 @default.
• W2556971034 hasAuthorship W2556971034A5068056974 @default.
• W2556971034 hasAuthorship W2556971034A5075280017 @default.
• W2556971034 hasAuthorship W2556971034A5081254876 @default.
• W2556971034 hasAuthorship W2556971034A5089277539 @default.
• W2556971034 hasBestOaLocation W25569710341 @default.
• W2556971034 hasConcept C121608353 @default.
• W2556971034 hasConcept C126322002 @default.
• W2556971034 hasConcept C143998085 @default.
• W2556971034 hasConcept C170493617 @default.
• W2556971034 hasConcept C2778260052 @default.
• W2556971034 hasConcept C2779013556 @default.
• W2556971034 hasConcept C2779804826 @default.
• W2556971034 hasConcept C2780962732 @default.
• W2556971034 hasConcept C502942594 @default.
• W2556971034 hasConcept C526805850 @default.
• W2556971034 hasConcept C66400584 @default.
• W2556971034 hasConcept C71924100 @default.
• W2556971034 hasConcept C74373430 @default.
• W2556971034 hasConcept C76419328 @default.
• W2556971034 hasConcept C82867764 @default.
• W2556971034 hasConceptScore W2556971034C121608353 @default.
• W2556971034 hasConceptScore W2556971034C126322002 @default.
• W2556971034 hasConceptScore W2556971034C143998085 @default.
• W2556971034 hasConceptScore W2556971034C170493617 @default.
• W2556971034 hasConceptScore W2556971034C2778260052 @default.
• W2556971034 hasConceptScore W2556971034C2779013556 @default.
• W2556971034 hasConceptScore W2556971034C2779804826 @default.
• W2556971034 hasConceptScore W2556971034C2780962732 @default.
• W2556971034 hasConceptScore W2556971034C502942594 @default.
• W2556971034 hasConceptScore W2556971034C526805850 @default.
• W2556971034 hasConceptScore W2556971034C66400584 @default.
• W2556971034 hasConceptScore W2556971034C71924100 @default.
• W2556971034 hasConceptScore W2556971034C74373430 @default.
• W2556971034 hasConceptScore W2556971034C76419328 @default.
• W2556971034 hasConceptScore W2556971034C82867764 @default.
• W2556971034 hasFunder F4320322120 @default.

• next