Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556975925> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2556975925 abstract "Background Supra-pharmacological doses of corticosteroids (pulse therapy) are used in various autoimmune disorders. Methylprednisolone and dexamethasone pulse therapy have demonstrated similar efficacy for some diseases;[1] therefore, differences in their adverse effects can help the selection of any of them. Objectives To evaluate changes in glycemia and blood pressure in patients who received pulse therapy with dexamethasone or methylprednisolone. Methods We evaluated the charts of patients who received corticosteroid pulse therapy with dexamethasone (200 mg/day) or methylprednisolone (1000 mg/day). We included patients who received at least three days of pulse therapy and who had records of glycemia and blood pressure four times at day. We evaluated the blood pressure and glycemia measurements before the first pulse therapy and the next three-day measurements each six hours. We evaluated through linear mixed models the factors associated with an increase in glycemia or blood pressure (systolic or diastolic) in the program R 3.0.2. For the glycemia analysis we excluded patients with diabetes history and patients having glycemia >180 before the pulse therapy. Results We included 117 patients, 83 received pulse therapy with methylprednisolone and 34 with dexamethasone. Multivariate mixed models showed a statistically significant increase in glycemia and blood pressure (systolic and diastolic) from the first measurement after the initial dose of pulse therapy (Figure 1); factors associated with hyperglycemia (adjusted for creatinine levels, sex and units of insulin received) were higher glycemia before the pulse therapy (p=0.0016) and the use of methylprednisolone (p=0.0098). Factors associated with an increase of systolic or diastolic blood pressure were: higher blood pressure before the first pulse therapy (p Conclusions Pulse therapy with methylprednisolone showed a higher increase in glycemia than dexamethasone. Susceptible patients to an increase of glycemia are who have initial hyperglycemia; patients susceptible to an increase in blood pressure are who have elevated serum creatinine levels and who have initial hypertension. References Sinha A, Bagga A. Pulse steroid therapy. Indian J Pediatr 2008;75:1057–66. Disclosure of Interest None declared" @default.
- W2556975925 created "2016-11-30" @default.
- W2556975925 creator A5020419106 @default.
- W2556975925 creator A5023638186 @default.
- W2556975925 creator A5033234854 @default.
- W2556975925 creator A5037079736 @default.
- W2556975925 creator A5048206157 @default.
- W2556975925 date "2016-06-01" @default.
- W2556975925 modified "2023-09-28" @default.
- W2556975925 title "AB1025 Glycemia and Systemic Blood Pressure in Patients Who Receive Corticosteroid Pulse Therapy" @default.
- W2556975925 doi "https://doi.org/10.1136/annrheumdis-2016-eular.6082" @default.
- W2556975925 hasPublicationYear "2016" @default.
- W2556975925 type Work @default.
- W2556975925 sameAs 2556975925 @default.
- W2556975925 citedByCount "0" @default.
- W2556975925 crossrefType "journal-article" @default.
- W2556975925 hasAuthorship W2556975925A5020419106 @default.
- W2556975925 hasAuthorship W2556975925A5023638186 @default.
- W2556975925 hasAuthorship W2556975925A5033234854 @default.
- W2556975925 hasAuthorship W2556975925A5037079736 @default.
- W2556975925 hasAuthorship W2556975925A5048206157 @default.
- W2556975925 hasConcept C126322002 @default.
- W2556975925 hasConcept C134018914 @default.
- W2556975925 hasConcept C17140001 @default.
- W2556975925 hasConcept C2776804153 @default.
- W2556975925 hasConcept C2780306776 @default.
- W2556975925 hasConcept C2780372218 @default.
- W2556975925 hasConcept C2780401358 @default.
- W2556975925 hasConcept C555293320 @default.
- W2556975925 hasConcept C71924100 @default.
- W2556975925 hasConcept C84393581 @default.
- W2556975925 hasConceptScore W2556975925C126322002 @default.
- W2556975925 hasConceptScore W2556975925C134018914 @default.
- W2556975925 hasConceptScore W2556975925C17140001 @default.
- W2556975925 hasConceptScore W2556975925C2776804153 @default.
- W2556975925 hasConceptScore W2556975925C2780306776 @default.
- W2556975925 hasConceptScore W2556975925C2780372218 @default.
- W2556975925 hasConceptScore W2556975925C2780401358 @default.
- W2556975925 hasConceptScore W2556975925C555293320 @default.
- W2556975925 hasConceptScore W2556975925C71924100 @default.
- W2556975925 hasConceptScore W2556975925C84393581 @default.
- W2556975925 hasLocation W25569759251 @default.
- W2556975925 hasOpenAccess W2556975925 @default.
- W2556975925 hasPrimaryLocation W25569759251 @default.
- W2556975925 hasRelatedWork W161597979 @default.
- W2556975925 hasRelatedWork W2008548381 @default.
- W2556975925 hasRelatedWork W2030121638 @default.
- W2556975925 hasRelatedWork W2043228490 @default.
- W2556975925 hasRelatedWork W2056370489 @default.
- W2556975925 hasRelatedWork W2090270332 @default.
- W2556975925 hasRelatedWork W2135804472 @default.
- W2556975925 hasRelatedWork W2202678366 @default.
- W2556975925 hasRelatedWork W2330033375 @default.
- W2556975925 hasRelatedWork W2384228437 @default.
- W2556975925 hasRelatedWork W2393096301 @default.
- W2556975925 hasRelatedWork W2415791936 @default.
- W2556975925 hasRelatedWork W2418127736 @default.
- W2556975925 hasRelatedWork W2420889091 @default.
- W2556975925 hasRelatedWork W2426979324 @default.
- W2556975925 hasRelatedWork W2993973729 @default.
- W2556975925 hasRelatedWork W3146694020 @default.
- W2556975925 hasRelatedWork W318106622 @default.
- W2556975925 hasRelatedWork W3190989774 @default.
- W2556975925 hasRelatedWork W38002901 @default.
- W2556975925 isParatext "false" @default.
- W2556975925 isRetracted "false" @default.
- W2556975925 magId "2556975925" @default.
- W2556975925 workType "article" @default.