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- W2556976275 abstract "Abstract Of 21 cats with chronic lesions of the hypothalamus (and in a few cases, prechiasmatic region) there was not a single case which showed a deviation of the fever curve in response to the intravenous injection of typhoid-paratyphoid vaccine in the direction of an increase in height or steepness of slope. Only one animal showed a typical normal fever curve. Twelve showed marked and prolonged temperature falls (3 ° to 11 ° F.) which lasted for a, period of twenty or more hours. Although such animals shivered normally in response to the injection of the vaccine, the temperature did not rise appreciably in response to such shivering; the pupillary dilatation which usually accompanies such periods of shivering and rising temperature in the normal animal was more often absent in these hypothalamic animals responding to the vaccine with hypothermia. Instead, there was pupillary constriction or the pupil was medium. There were often coincident signs of parasympathetic overactivity, such as defecation, urination, and salivation. The respiratory rate increased markedly, greatly exceeding that seen in the normal series of cats. It is impossible at this time to make any definite anatomical localization for lesions resulting in this reaction. It does not appear to be important whether the lesions are laterally or medially, rostrally or caudally placed, or whether the lesion results in a disturbance in the normal regulation of body temperature. A hypothalamic lesion which results in a hypothermic reaction to the injection of typhoid-paratyphoid vaccine intravenously does not prevent the animal from responding to the intravenous injection of alpha-dinitrophenol with a typical febrile response. The part of the heat-loss mechanism which is activated by the intravenous injection of typhoid-paratyphoid vaccine does not lie in the hypothalamus but somewhere caudal to it." @default.
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- W2556976275 date "1939-11-01" @default.
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- W2556976275 title "The effect of hypothalamic lesions on fever induced by intravenous injection of typhoid-paratyphoid vaccine" @default.
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- W2556976275 doi "https://doi.org/10.5555/uri:pii:s0022214339902076" @default.
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