Matches in SemOpenAlex for { <https://semopenalex.org/work/W2556982851> ?p ?o ?g. }
- W2556982851 endingPage "952" @default.
- W2556982851 startingPage "946" @default.
- W2556982851 abstract "The Michael addition reactions of the biothiols cysteine (Cys), glutathione (GSH), homocysteine (Hcy) and cysteinylglycine (Cys‐Gly) with ( E )‐3‐(3‐(2‐methoxyphenyl)acryloyl)‐7‐methoxy‐2 H ‐chromen‐2‐one and ( E )‐3‐(3‐(3‐methoxyphenyl)acryloyl)‐7‐methoxy‐2 H ‐chromen‐2‐one (ChC2 and ChC3, respectively) in aqueous solution (25 °C, ionic strength 0.2 M KCl) were followed fluorimetrically and evaluated kinetically. With a large excess of biothiol, pseudo‐first‐order rate coefficients ( k obsd ) were found. Plots of k obsd versus [biothiolate] are linear, with a pH‐independent slope ( k N ). With the kinetic results obtained, the following conclusions can be drawn: (i) the reactivity increases in the sequence Cys‐Gly < Hcy < GSH < Cys; (ii) similar reactivity toward biothiols was found for ChC2 and ChC3, and both probes are more reactive than ( E )‐3‐cinnamoyl‐7‐methoxy‐2 H ‐chromen‐2‐one (ChC1); (iii) ChC2 and ChC3 display a highly selective fluorescence enhancement with biothiols, allowing these probes to be used for fluorimetric biothiol determination in SH‐SY5Y cells. Copyright © 2012 John Wiley & Sons, Ltd." @default.
- W2556982851 created "2016-11-30" @default.
- W2556982851 creator A5007918342 @default.
- W2556982851 creator A5041256719 @default.
- W2556982851 creator A5042538989 @default.
- W2556982851 creator A5045357638 @default.
- W2556982851 creator A5045840806 @default.
- W2556982851 creator A5046153457 @default.
- W2556982851 creator A5051168857 @default.
- W2556982851 creator A5073113301 @default.
- W2556982851 creator A5084916873 @default.
- W2556982851 date "2012-06-15" @default.
- W2556982851 modified "2023-10-06" @default.
- W2556982851 title "Nucleophilic reactivity of biothiols toward coumarin‐based derivatives containing a chalcone moiety" @default.
- W2556982851 cites W1965147029 @default.
- W2556982851 cites W1965789997 @default.
- W2556982851 cites W1983242115 @default.
- W2556982851 cites W1985953764 @default.
- W2556982851 cites W1986319156 @default.
- W2556982851 cites W1987139608 @default.
- W2556982851 cites W1991950902 @default.
- W2556982851 cites W1994479337 @default.
- W2556982851 cites W2003659770 @default.
- W2556982851 cites W2012848498 @default.
- W2556982851 cites W2020753003 @default.
- W2556982851 cites W2025976054 @default.
- W2556982851 cites W2033469619 @default.
- W2556982851 cites W2040382777 @default.
- W2556982851 cites W2042249621 @default.
- W2556982851 cites W2051682290 @default.
- W2556982851 cites W2052199071 @default.
- W2556982851 cites W2055046703 @default.
- W2556982851 cites W2058919668 @default.
- W2556982851 cites W2060528553 @default.
- W2556982851 cites W2065773831 @default.
- W2556982851 cites W2110783613 @default.
- W2556982851 cites W2114744780 @default.
- W2556982851 cites W2115588205 @default.
- W2556982851 cites W2139126163 @default.
- W2556982851 cites W2160790360 @default.
- W2556982851 cites W2170703297 @default.
- W2556982851 cites W2317172136 @default.
- W2556982851 cites W2321535271 @default.
- W2556982851 doi "https://doi.org/10.1002/poc.2975" @default.
- W2556982851 hasPublicationYear "2012" @default.
- W2556982851 type Work @default.
- W2556982851 sameAs 2556982851 @default.
- W2556982851 citedByCount "12" @default.
- W2556982851 countsByYear W25569828512014 @default.
- W2556982851 countsByYear W25569828512015 @default.
- W2556982851 countsByYear W25569828512016 @default.
- W2556982851 countsByYear W25569828512017 @default.
- W2556982851 countsByYear W25569828512018 @default.
- W2556982851 countsByYear W25569828512019 @default.
- W2556982851 countsByYear W25569828512020 @default.
- W2556982851 crossrefType "journal-article" @default.
- W2556982851 hasAuthorship W2556982851A5007918342 @default.
- W2556982851 hasAuthorship W2556982851A5041256719 @default.
- W2556982851 hasAuthorship W2556982851A5042538989 @default.
- W2556982851 hasAuthorship W2556982851A5045357638 @default.
- W2556982851 hasAuthorship W2556982851A5045840806 @default.
- W2556982851 hasAuthorship W2556982851A5046153457 @default.
- W2556982851 hasAuthorship W2556982851A5051168857 @default.
- W2556982851 hasAuthorship W2556982851A5073113301 @default.
- W2556982851 hasAuthorship W2556982851A5084916873 @default.
- W2556982851 hasConcept C112423150 @default.
- W2556982851 hasConcept C142724271 @default.
- W2556982851 hasConcept C155647269 @default.
- W2556982851 hasConcept C161790260 @default.
- W2556982851 hasConcept C178790620 @default.
- W2556982851 hasConcept C178907741 @default.
- W2556982851 hasConcept C181199279 @default.
- W2556982851 hasConcept C185592680 @default.
- W2556982851 hasConcept C204787440 @default.
- W2556982851 hasConcept C20774148 @default.
- W2556982851 hasConcept C2776568683 @default.
- W2556982851 hasConcept C2776910235 @default.
- W2556982851 hasConcept C2777090595 @default.
- W2556982851 hasConcept C2779201268 @default.
- W2556982851 hasConcept C2780105360 @default.
- W2556982851 hasConcept C2780764945 @default.
- W2556982851 hasConcept C2781338262 @default.
- W2556982851 hasConcept C538909803 @default.
- W2556982851 hasConcept C55493867 @default.
- W2556982851 hasConcept C71240020 @default.
- W2556982851 hasConcept C71924100 @default.
- W2556982851 hasConceptScore W2556982851C112423150 @default.
- W2556982851 hasConceptScore W2556982851C142724271 @default.
- W2556982851 hasConceptScore W2556982851C155647269 @default.
- W2556982851 hasConceptScore W2556982851C161790260 @default.
- W2556982851 hasConceptScore W2556982851C178790620 @default.
- W2556982851 hasConceptScore W2556982851C178907741 @default.
- W2556982851 hasConceptScore W2556982851C181199279 @default.
- W2556982851 hasConceptScore W2556982851C185592680 @default.
- W2556982851 hasConceptScore W2556982851C204787440 @default.
- W2556982851 hasConceptScore W2556982851C20774148 @default.
- W2556982851 hasConceptScore W2556982851C2776568683 @default.
- W2556982851 hasConceptScore W2556982851C2776910235 @default.