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• W2557087988 abstract "Purpose To remove the confounding effect of unsuppressed fat on the imaging‐based apparent diffusion coefficient (ADC) of the vertebral bone marrow water component when using spectrally selective fat suppression and to compare and validate the proposed quantification strategy against diffusion‐weighted magnetic resonance spectroscopy (DW‐MRS). Methods Twelve subjects underwent diffusion‐weighted imaging (DWI) and DW‐MRS of the vertebral bone marrow. A theoretical model was developed to take into account and correct the effects of residual fat on ADC, incorporating additional measurements for proton density fat fraction (PDFF) and water T 2 (T 2w ). Uncorrected and corrected DWI‐based ADC was compared with DW‐MRS–based ADC using the Bland–Altman method. Results There was a systematic bias equal to 0.118 ± 0.116 × 10 −3 mm 2 /s between DWI and DW‐MRS when no correction was performed. Taking into account measured PDFF and constant T 2w reduced the bias to 0.006 ± 0.128 × 10 −3 mm 2 /s. Using the proposed approach with both individually measured PDFF and T 2w reduced both the bias and the limits of agreement between DWI and DW‐MRS (0.018 ± 0.065 × 10 −3 mm 2 /s). Conclusion By taking into account the presence of residual fat in a modified signal model that incorporates additional individual measurements of PDFF and T 2w , good agreement of imaging‐based ADC with MRS‐based ADC can be achieved in vertebral bone marrow. Magn Reson Med 78:1432–1441, 2017. © 2016 International Society for Magnetic Resonance in Medicine." @default.
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• W2557087988 date "2016-11-08" @default.
• W2557087988 modified "2023-10-06" @default.
• W2557087988 title "ADC Quantification of the Vertebral Bone Marrow Water Component: Removing the Confounding Effect of Residual Fat" @default.
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• W2557087988 doi "https://doi.org/10.1002/mrm.26550" @default.
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