FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557100573> ?p ?o ?g. }

• W2557100573 abstract "Background. Apoptotic mesangial cell death has been regarded mainly as a homeostatic mechanism reducing glo− merular hypercellularity in glomerulonephritis. Nonetheless, in the early anti−thymocyte serum nephritis (ATSN) apoptosis has been attributable to excessive generation of nitric oxide. Objectives. The authors reasoned that NO−dependent mesangial apoptosis may represent a mechanism of patholo− gic glomerular cell depletion, initiating tissue injury in this nephritis model, along with mesangiolysis mediated by complement. Material and Methods. In five sets of experiments rats were sacrificed on days 0–4 after injection of ATS and renal tissue samples assessed for glomerular cell count, expression of mRNA for iNOS (RT−PCR in situ) and apop− tosis of glomerular cells (TUNEL technique). In addition, release of nitrite by isolated renal glomeruli was assessed and glomerular cells checked for proliferating cell nuclear antigen (PCNA) and for infiltrating monocy− tes/macrophages by immunostaining. In parallel, a group of ATSN rats receiving an iNOS inhibitor, N ω −nitro−L− arginino−methyl ether (L−NAME) was enrolled in each experiment. Results. On days 0–4 post ATS injection proteinuria gradually increased, whereas in ATSN rats given L−NAME proteinuria was markedly lower (day 4: p < 0.0005). Similarly to proteinuria, the extent of mesangiolysis increased on days 0–3 (glomerular cell count: day 0 vs. day 3: p < 0.005) and was significantly reduced by L−NAME (p < 0.005). Apoptosis of glomerular cells increased during course of ATSN in a manner comparable to that of pro− teinuria and mesangiolysis and was also partly preventable by L−NAME (apoptotic cell count, day 3: ATS vs. ATS + L−NAME, p < 0.05). Treatment with L−NAME did not interfere with glomerular binding of ATS nor depo− sition of C3 (immunostaining). Apoptotic cell number was significantly inversely correlated with glomerular cell count. Glomerular expression of mRNA for iNOS and generation of NO2 in glomeruli peaked on day 2, preceding the highest activity of apoptosis and intensity of glomerulonephritis (proteinuria, mesangiolysis). Generation of nitrite was markedly correlated with the extent of mesangial cell depletion (day 2, p < 0.04). Conclusion. In the mesangiolytic phase of ATSN, high local activity of iNOS is involved in pathogenic apoptosis" @default.
• W2557100573 created "2016-11-30" @default.
• W2557100573 creator A5025544148 @default.
• W2557100573 date "2005-01-01" @default.
• W2557100573 modified "2023-09-23" @default.
• W2557100573 title "Pathogenic Apoptosis of Glomerular Cells in Experimental Nephritis Is Partly Nitric Oxide−Dependent Zależność patologicznej apoptozy komórek kłębuszków nerkowych od tlenku azotu w doświadczalnym zapaleniu nerek" @default.
• W2557100573 cites W1748526476 @default.
• W2557100573 cites W1992244664 @default.
• W2557100573 cites W1997277409 @default.
• W2557100573 cites W1998612739 @default.
• W2557100573 cites W2007882975 @default.
• W2557100573 cites W2009393201 @default.
• W2557100573 cites W2020736389 @default.
• W2557100573 cites W2025535432 @default.
• W2557100573 cites W2035245185 @default.
• W2557100573 cites W2052853635 @default.
• W2557100573 cites W2057655548 @default.
• W2557100573 cites W2059736568 @default.
• W2557100573 cites W2066549657 @default.
• W2557100573 cites W2073951465 @default.
• W2557100573 cites W2085964942 @default.
• W2557100573 cites W2094610390 @default.
• W2557100573 cites W2136397838 @default.
• W2557100573 cites W2138302361 @default.
• W2557100573 cites W2148802230 @default.
• W2557100573 cites W2149181579 @default.
• W2557100573 cites W223711920 @default.
• W2557100573 cites W236318789 @default.
• W2557100573 cites W2412710802 @default.
• W2557100573 hasPublicationYear "2005" @default.
• W2557100573 type Work @default.
• W2557100573 sameAs 2557100573 @default.
• W2557100573 citedByCount "0" @default.
• W2557100573 crossrefType "journal-article" @default.
• W2557100573 hasAuthorship W2557100573A5025544148 @default.
• W2557100573 hasConcept C126322002 @default.
• W2557100573 hasConcept C134018914 @default.
• W2557100573 hasConcept C190283241 @default.
• W2557100573 hasConcept C203014093 @default.
• W2557100573 hasConcept C2779131090 @default.
• W2557100573 hasConcept C2779561371 @default.
• W2557100573 hasConcept C2780091579 @default.
• W2557100573 hasConcept C2780368995 @default.
• W2557100573 hasConcept C3018920779 @default.
• W2557100573 hasConcept C519581460 @default.
• W2557100573 hasConcept C55493867 @default.
• W2557100573 hasConcept C71924100 @default.
• W2557100573 hasConcept C86803240 @default.
• W2557100573 hasConceptScore W2557100573C126322002 @default.
• W2557100573 hasConceptScore W2557100573C134018914 @default.
• W2557100573 hasConceptScore W2557100573C190283241 @default.
• W2557100573 hasConceptScore W2557100573C203014093 @default.
• W2557100573 hasConceptScore W2557100573C2779131090 @default.
• W2557100573 hasConceptScore W2557100573C2779561371 @default.
• W2557100573 hasConceptScore W2557100573C2780091579 @default.
• W2557100573 hasConceptScore W2557100573C2780368995 @default.
• W2557100573 hasConceptScore W2557100573C3018920779 @default.
• W2557100573 hasConceptScore W2557100573C519581460 @default.
• W2557100573 hasConceptScore W2557100573C55493867 @default.
• W2557100573 hasConceptScore W2557100573C71924100 @default.
• W2557100573 hasConceptScore W2557100573C86803240 @default.
• W2557100573 hasLocation W25571005731 @default.
• W2557100573 hasOpenAccess W2557100573 @default.
• W2557100573 hasPrimaryLocation W25571005731 @default.
• W2557100573 isParatext "false" @default.
• W2557100573 isRetracted "false" @default.
• W2557100573 magId "2557100573" @default.
• W2557100573 workType "article" @default.