FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557100819> ?p ?o ?g. }

• W2557100819 endingPage "23" @default.
• W2557100819 startingPage "12" @default.
• W2557100819 abstract "Triple-negative breast cancer (TNBC) is characterized by high vascularity and frequent metastasis. Here, we found that activation of G protein-coupled estrogen receptor (GPER) by its specific agonist G-1 can significantly inhibit interleukin 6 (IL-6) and vascular endothelial growth factor A (VEGF-A). TNBC tissue microarrays from 100 TNBC patients revealed GPER is negatively associated with IL-6 levels and higher grade and stage. Activation of GPER or anti-IL-6 antibody can inhibit both in vitro tube formation of human umbilical vein endothelial cells (HUVECs) and migration of TNBC cells. While recombinant IL-6 supplementary can significantly reverse the inhibitory effects of G-1, suggesting the essential role of IL-6 in G-1 induced suppression of angiogenesis and invasiveness of TNBC cells. G-1 treatment decreased the phosphorylation, nuclear localization, transcriptional activities of NF-κB and suppressed its binding with IL-6 promoter. BAY11-7028, the inhibitor of NF-κB, can mimic the effect of G-1 to suppression of IL-6 and VEGF-A. While over expression of p65 can attenuate the inhibitory effects of G-1 on IL-6 and VEGF expression. The suppression of IL-6 by G-1 can further inhibit HIF-1α and STAT3 signals in TNBC cells by inhibition their expression, phosphorylation and/or nuclear localization. Moreover, G-1 also inhibited the in vivo NF-κB/IL-6 signals and angiogenesis and metastasis of MDA-MB-231 xenograft tumors. In conclusion, our study demonstrated that activation of GPER can suppress migration and angiogenesis of TNBC via inhibition of NF-κB/IL-6 signals, therefore it maybe act as an important target for TNBC treatment." @default.
• W2557100819 created "2016-11-30" @default.
• W2557100819 creator A5007769872 @default.
• W2557100819 creator A5008180872 @default.
• W2557100819 creator A5023528325 @default.
• W2557100819 creator A5034216326 @default.
• W2557100819 creator A5058814917 @default.
• W2557100819 creator A5060282383 @default.
• W2557100819 creator A5064421875 @default.
• W2557100819 creator A5070002933 @default.
• W2557100819 creator A5088961144 @default.
• W2557100819 date "2017-02-01" @default.
• W2557100819 modified "2023-10-16" @default.
• W2557100819 title "Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibition of NF-κB/IL-6 signals" @default.
• W2557100819 cites W1493114845 @default.
• W2557100819 cites W1505106591 @default.
• W2557100819 cites W1707828128 @default.
• W2557100819 cites W1953357409 @default.
• W2557100819 cites W1955390608 @default.
• W2557100819 cites W1969738534 @default.
• W2557100819 cites W1979692390 @default.
• W2557100819 cites W1991063693 @default.
• W2557100819 cites W1992112921 @default.
• W2557100819 cites W1995189261 @default.
• W2557100819 cites W1997365308 @default.
• W2557100819 cites W1999251458 @default.
• W2557100819 cites W2001494971 @default.
• W2557100819 cites W2024893745 @default.
• W2557100819 cites W2025138095 @default.
• W2557100819 cites W2034057442 @default.
• W2557100819 cites W2037262701 @default.
• W2557100819 cites W2044227662 @default.
• W2557100819 cites W2053298425 @default.
• W2557100819 cites W2059287377 @default.
• W2557100819 cites W2067926469 @default.
• W2557100819 cites W2068803310 @default.
• W2557100819 cites W2074196937 @default.
• W2557100819 cites W2075443461 @default.
• W2557100819 cites W2078558213 @default.
• W2557100819 cites W2082833890 @default.
• W2557100819 cites W2087115854 @default.
• W2557100819 cites W2088144381 @default.
• W2557100819 cites W2095274546 @default.
• W2557100819 cites W2097147259 @default.
• W2557100819 cites W2104638648 @default.
• W2557100819 cites W2107554353 @default.
• W2557100819 cites W2115585914 @default.
• W2557100819 cites W2115976071 @default.
• W2557100819 cites W2122378278 @default.
• W2557100819 cites W2126275851 @default.
• W2557100819 cites W2134053452 @default.
• W2557100819 cites W2134539328 @default.
• W2557100819 cites W2138474420 @default.
• W2557100819 cites W2153982924 @default.
• W2557100819 cites W2162121911 @default.
• W2557100819 cites W2168113107 @default.
• W2557100819 cites W2266639016 @default.
• W2557100819 cites W2285354269 @default.
• W2557100819 cites W2340696274 @default.
• W2557100819 cites W2508384317 @default.
• W2557100819 cites W4377889095 @default.
• W2557100819 cites W3145281514 @default.
• W2557100819 doi "https://doi.org/10.1016/j.canlet.2016.11.003" @default.
• W2557100819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27836733" @default.
• W2557100819 hasPublicationYear "2017" @default.
• W2557100819 type Work @default.
• W2557100819 sameAs 2557100819 @default.
• W2557100819 citedByCount "91" @default.
• W2557100819 countsByYear W25571008192017 @default.
• W2557100819 countsByYear W25571008192018 @default.
• W2557100819 countsByYear W25571008192019 @default.
• W2557100819 countsByYear W25571008192020 @default.
• W2557100819 countsByYear W25571008192021 @default.
• W2557100819 countsByYear W25571008192022 @default.
• W2557100819 countsByYear W25571008192023 @default.
• W2557100819 crossrefType "journal-article" @default.
• W2557100819 hasAuthorship W2557100819A5007769872 @default.
• W2557100819 hasAuthorship W2557100819A5008180872 @default.
• W2557100819 hasAuthorship W2557100819A5023528325 @default.
• W2557100819 hasAuthorship W2557100819A5034216326 @default.
• W2557100819 hasAuthorship W2557100819A5058814917 @default.
• W2557100819 hasAuthorship W2557100819A5060282383 @default.
• W2557100819 hasAuthorship W2557100819A5064421875 @default.
• W2557100819 hasAuthorship W2557100819A5070002933 @default.
• W2557100819 hasAuthorship W2557100819A5088961144 @default.
• W2557100819 hasConcept C11960822 @default.
• W2557100819 hasConcept C121608353 @default.
• W2557100819 hasConcept C126322002 @default.
• W2557100819 hasConcept C166471694 @default.
• W2557100819 hasConcept C185592680 @default.
• W2557100819 hasConcept C2777730290 @default.
• W2557100819 hasConcept C2778923194 @default.
• W2557100819 hasConcept C2779013556 @default.
• W2557100819 hasConcept C2779730028 @default.
• W2557100819 hasConcept C2780110267 @default.
• W2557100819 hasConcept C2780394083 @default.
• W2557100819 hasConcept C502942594 @default.
• W2557100819 hasConcept C530470458 @default.

• next