FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557114865> ?p ?o ?g. }

• W2557114865 abstract "ABSTRACT Horizontal gene transfer may occur between distantly related bacteria, thus leading to genetic plasticity and in some cases to acquisition of novel resistance traits . Proteus mirabilis is an enterobacterial species responsible for human infections that may express various acquired β-lactam resistance genes, including different classes of carbapenemase genes. Here we report a Proteus mirabilis clinical isolate (strain 1091) displaying resistance to penicillin, including temocillin, together with reduced susceptibility to carbapenems and susceptibility to expanded-spectrum cephalosporins. Using biochemical tests, significant carbapenem hydrolysis was detected in P. mirabilis 1091. Since PCR failed to detect acquired carbapenemase genes commonly found in Enterobacteriaceae , we used a whole-genome sequencing approach that revealed the presence of bla OXA-58 class D carbapenemase gene, so far identified only in Acinetobacter species. This gene was located on a 3.1-kb element coharboring a bla AmpC -like gene. Remarkably, these two genes were bracketed by putative XerC-XerD binding sites and inserted at a XerC-XerD site located between the terminase-like small- and large-subunit genes of a bacteriophage. Increased expression of the two bla genes resulted from a 6-time tandem amplification of the element as revealed by Southern blotting. This is the first isolation of a clinical P. mirabilis strain producing OXA-58, a class D carbapenemase, and the first description of a XerC-XerD-dependent insertion of antibiotic resistance genes within a bacteriophage. This study revealed a new role for the XerC-XerD recombinase in bacteriophage biology." @default.
• W2557114865 created "2016-11-30" @default.
• W2557114865 creator A5001355515 @default.
• W2557114865 creator A5008710955 @default.
• W2557114865 creator A5013036515 @default.
• W2557114865 creator A5016122595 @default.
• W2557114865 creator A5035086338 @default.
• W2557114865 creator A5037361850 @default.
• W2557114865 creator A5041618073 @default.
• W2557114865 creator A5045515878 @default.
• W2557114865 date "2017-02-01" @default.
• W2557114865 modified "2023-09-26" @default.
• W2557114865 title "Chromosomal Amplification of the <i>bla</i> _OXA-58 Carbapenemase Gene in a Proteus mirabilis Clinical Isolate" @default.
• W2557114865 cites W1759202011 @default.
• W2557114865 cites W1991664494 @default.
• W2557114865 cites W1995234983 @default.
• W2557114865 cites W1997393091 @default.
• W2557114865 cites W1997495012 @default.
• W2557114865 cites W2004548026 @default.
• W2557114865 cites W2006993214 @default.
• W2557114865 cites W2021212281 @default.
• W2557114865 cites W2022418395 @default.
• W2557114865 cites W2031240692 @default.
• W2557114865 cites W2043467608 @default.
• W2557114865 cites W2077845709 @default.
• W2557114865 cites W2085690765 @default.
• W2557114865 cites W2085963382 @default.
• W2557114865 cites W2101996554 @default.
• W2557114865 cites W2129328541 @default.
• W2557114865 cites W2134852597 @default.
• W2557114865 cites W2140029549 @default.
• W2557114865 cites W2140135238 @default.
• W2557114865 cites W2140263219 @default.
• W2557114865 cites W2141105958 @default.
• W2557114865 cites W2145915746 @default.
• W2557114865 cites W2149161141 @default.
• W2557114865 cites W2152232748 @default.
• W2557114865 cites W2156473421 @default.
• W2557114865 cites W2160921480 @default.
• W2557114865 cites W2168445320 @default.
• W2557114865 cites W2171348592 @default.
• W2557114865 cites W2183303995 @default.
• W2557114865 cites W2285766501 @default.
• W2557114865 cites W2307053896 @default.
• W2557114865 cites W2333310033 @default.
• W2557114865 cites W888995547 @default.
• W2557114865 doi "https://doi.org/10.1128/aac.01697-16" @default.
• W2557114865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5278702" @default.
• W2557114865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27855079" @default.
• W2557114865 hasPublicationYear "2017" @default.
• W2557114865 type Work @default.
• W2557114865 sameAs 2557114865 @default.
• W2557114865 citedByCount "35" @default.
• W2557114865 countsByYear W25571148652017 @default.
• W2557114865 countsByYear W25571148652018 @default.
• W2557114865 countsByYear W25571148652019 @default.
• W2557114865 countsByYear W25571148652020 @default.
• W2557114865 countsByYear W25571148652021 @default.
• W2557114865 countsByYear W25571148652022 @default.
• W2557114865 crossrefType "journal-article" @default.
• W2557114865 hasAuthorship W2557114865A5001355515 @default.
• W2557114865 hasAuthorship W2557114865A5008710955 @default.
• W2557114865 hasAuthorship W2557114865A5013036515 @default.
• W2557114865 hasAuthorship W2557114865A5016122595 @default.
• W2557114865 hasAuthorship W2557114865A5035086338 @default.
• W2557114865 hasAuthorship W2557114865A5037361850 @default.
• W2557114865 hasAuthorship W2557114865A5041618073 @default.
• W2557114865 hasAuthorship W2557114865A5045515878 @default.
• W2557114865 hasBestOaLocation W25571148651 @default.
• W2557114865 hasConcept C102414288 @default.
• W2557114865 hasConcept C104317684 @default.
• W2557114865 hasConcept C141231307 @default.
• W2557114865 hasConcept C156695909 @default.
• W2557114865 hasConcept C2776441376 @default.
• W2557114865 hasConcept C2778039505 @default.
• W2557114865 hasConcept C54355233 @default.
• W2557114865 hasConcept C547475151 @default.
• W2557114865 hasConcept C86803240 @default.
• W2557114865 hasConcept C89423630 @default.
• W2557114865 hasConcept C92938381 @default.
• W2557114865 hasConceptScore W2557114865C102414288 @default.
• W2557114865 hasConceptScore W2557114865C104317684 @default.
• W2557114865 hasConceptScore W2557114865C141231307 @default.
• W2557114865 hasConceptScore W2557114865C156695909 @default.
• W2557114865 hasConceptScore W2557114865C2776441376 @default.
• W2557114865 hasConceptScore W2557114865C2778039505 @default.
• W2557114865 hasConceptScore W2557114865C54355233 @default.
• W2557114865 hasConceptScore W2557114865C547475151 @default.
• W2557114865 hasConceptScore W2557114865C86803240 @default.
• W2557114865 hasConceptScore W2557114865C89423630 @default.
• W2557114865 hasConceptScore W2557114865C92938381 @default.
• W2557114865 hasFunder F4320327337 @default.
• W2557114865 hasIssue "2" @default.
• W2557114865 hasLocation W25571148651 @default.
• W2557114865 hasLocation W25571148652 @default.
• W2557114865 hasLocation W25571148653 @default.
• W2557114865 hasLocation W25571148654 @default.
• W2557114865 hasOpenAccess W2557114865 @default.
• W2557114865 hasPrimaryLocation W25571148651 @default.
• W2557114865 hasRelatedWork W2019988726 @default.

• next