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- W2557142015 abstract "Studies of the polymorphism of central metabolic genes as a source of fitness variation in natural populations date back to the discovery of allozymes in the 1960s. The unique features of these genes and their enzymes and our knowledge base greatly facilitates the systems-level study of this group. The expectation that pathway flux control is central to understanding the molecular evolution of genes is discussed, as well as studies that attempt to place gene-specific molecular evolution and polymorphism into a context of pathway and network architecture. There is an increasingly complex picture of the metabolic genes assuming additional roles beyond their textbook anabolic and catabolic reactions. In particular, this review emphasizes the potential role of these genes as part of the energy-sensing machinery. It is underscored that the concentrations of key cellular metabolites are the reflections of cellular energy status and nutritional input. These metabolites are the top-down signaling messengers that set signaling through signaling pathways that are involved in energy economy. I propose that the polymorphisms in central metabolic genes shift metabolite concentrations and in that fashion act as genetic modifiers of the energy-state coupling to the transcriptional networks that affect physiological trade-offs with significant fitness consequences." @default.
- W2557142015 created "2016-11-30" @default.
- W2557142015 creator A5060495478 @default.
- W2557142015 date "2016-11-10" @default.
- W2557142015 modified "2023-09-25" @default.
- W2557142015 title "New views on the selection acting on genetic polymorphism in central metabolic genes" @default.
- W2557142015 cites W1496425054 @default.
- W2557142015 cites W1500102961 @default.
- W2557142015 cites W1514689437 @default.
- W2557142015 cites W1519389642 @default.
- W2557142015 cites W1530586632 @default.
- W2557142015 cites W1561252486 @default.
- W2557142015 cites W1565820922 @default.
- W2557142015 cites W1565979608 @default.
- W2557142015 cites W1576638368 @default.
- W2557142015 cites W1599939326 @default.
- W2557142015 cites W1864895841 @default.
- W2557142015 cites W1946157893 @default.
- W2557142015 cites W1964150693 @default.
- W2557142015 cites W1965495036 @default.
- W2557142015 cites W1966392395 @default.
- W2557142015 cites W1967500610 @default.
- W2557142015 cites W1969539025 @default.
- W2557142015 cites W1971413372 @default.
- W2557142015 cites W1974318258 @default.
- W2557142015 cites W1975005151 @default.
- W2557142015 cites W1976445111 @default.
- W2557142015 cites W1980666158 @default.
- W2557142015 cites W1982603712 @default.
- W2557142015 cites W1983202741 @default.
- W2557142015 cites W1984745567 @default.
- W2557142015 cites W1988493914 @default.
- W2557142015 cites W1988960717 @default.
- W2557142015 cites W1989425898 @default.
- W2557142015 cites W1989821641 @default.
- W2557142015 cites W1991246227 @default.
- W2557142015 cites W1991429659 @default.
- W2557142015 cites W1992455697 @default.
- W2557142015 cites W1992495736 @default.
- W2557142015 cites W1993355054 @default.
- W2557142015 cites W1995164611 @default.
- W2557142015 cites W1996180430 @default.
- W2557142015 cites W1997012028 @default.
- W2557142015 cites W1997116773 @default.
- W2557142015 cites W1998334660 @default.
- W2557142015 cites W2000923281 @default.
- W2557142015 cites W2004849589 @default.
- W2557142015 cites W2005245900 @default.
- W2557142015 cites W2005983216 @default.
- W2557142015 cites W2006209005 @default.
- W2557142015 cites W2006822568 @default.
- W2557142015 cites W2007125373 @default.
- W2557142015 cites W2007636825 @default.
- W2557142015 cites W2008821714 @default.
- W2557142015 cites W2013658326 @default.
- W2557142015 cites W2015924572 @default.
- W2557142015 cites W2017115075 @default.
- W2557142015 cites W2017578869 @default.
- W2557142015 cites W2020110583 @default.
- W2557142015 cites W2020665084 @default.
- W2557142015 cites W2020993937 @default.
- W2557142015 cites W2021469756 @default.
- W2557142015 cites W2022267544 @default.
- W2557142015 cites W2028013329 @default.
- W2557142015 cites W2030914984 @default.
- W2557142015 cites W2031046866 @default.
- W2557142015 cites W2031050244 @default.
- W2557142015 cites W2031911789 @default.
- W2557142015 cites W2032143276 @default.
- W2557142015 cites W2032462953 @default.
- W2557142015 cites W2033682352 @default.
- W2557142015 cites W2036573675 @default.
- W2557142015 cites W2039504117 @default.
- W2557142015 cites W2039671079 @default.
- W2557142015 cites W2042605932 @default.
- W2557142015 cites W2047395622 @default.
- W2557142015 cites W2047683380 @default.
- W2557142015 cites W2048903522 @default.
- W2557142015 cites W2051242197 @default.
- W2557142015 cites W2059914722 @default.
- W2557142015 cites W2060435573 @default.
- W2557142015 cites W2060869324 @default.
- W2557142015 cites W2062935524 @default.
- W2557142015 cites W2063779182 @default.
- W2557142015 cites W2064535527 @default.
- W2557142015 cites W2064885805 @default.
- W2557142015 cites W2072201802 @default.
- W2557142015 cites W2072451938 @default.
- W2557142015 cites W2074190281 @default.
- W2557142015 cites W2076841301 @default.
- W2557142015 cites W2078355959 @default.
- W2557142015 cites W2079366428 @default.
- W2557142015 cites W2080094749 @default.
- W2557142015 cites W2080107084 @default.
- W2557142015 cites W2081869206 @default.
- W2557142015 cites W2081969319 @default.
- W2557142015 cites W2083653513 @default.
- W2557142015 cites W2084128271 @default.