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• W2557150912 abstract "Molecular inhibitors are commonly employed in natural, synthetic, and biological crystallization as a means of regulating crystal size and habit. In pathological crystallization, growth inhibitors are commonly employed as therapies to decrease the rate of crystal growth, thereby reducing the incidence rate of diseases. When designing inhibitors for such purposes, it is often unknown a priori what properties (e.g., structure, functionality) are critical for drug efficacy and specificity. Identification of lead candidates is often accomplished through brute force screening without knowledge of the molecular-level driving force(s) governing favorable inhibitor–crystal interactions. Here, we present a biomimetic assay to characterize the crystallization of hematin, a critical component of Plasmodium parasite survival in malaria. Many antimalarial drugs have been shown to function as inhibitors that suppress hematin crystal growth. The increasing resistance of malaria parasites to current antimalarials has created an impetus to design alternative drugs; however, current approaches to identify lead candidates rely on combinatorial methods employing parasite assays to screen compounds, which are incapable of elucidating the effect(s) of inhibitors on hematin crystallization. In this study, we use citric-buffer saturated octanol (CBSO) as a physiologically relevant growth medium to develop a facile, robust method of screening compounds that inhibit hematin crystal growth. As benchmarks, we selected antimalarials and antibiotics that are commonly used in combination therapies. We assessed drug solubility in CBSO and designed a biomimetic assay to quantify the relative efficiency of hematin growth inhibitors. We demonstrate that this assay can be used as a high-throughput platform to screen libraries of compounds as a more streamlined approach to identify inhibitors of pathological crystallization." @default.
• W2557150912 created "2016-11-30" @default.
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• W2557150912 date "2016-11-30" @default.
• W2557150912 modified "2023-10-17" @default.
• W2557150912 title "Biomimetic Assay for Hematin Crystallization Inhibitors: A New Platform To Screen Antimalarial Drugs" @default.
• W2557150912 cites W1493715460 @default.
• W2557150912 cites W1876118699 @default.
• W2557150912 cites W1921743339 @default.
• W2557150912 cites W1965324548 @default.
• W2557150912 cites W1966248923 @default.
• W2557150912 cites W1968225400 @default.
• W2557150912 cites W1973470114 @default.
• W2557150912 cites W1984198087 @default.
• W2557150912 cites W1987311633 @default.
• W2557150912 cites W1990814829 @default.
• W2557150912 cites W1993213550 @default.
• W2557150912 cites W1993427372 @default.
• W2557150912 cites W1993465504 @default.
• W2557150912 cites W1995243160 @default.
• W2557150912 cites W1998608454 @default.
• W2557150912 cites W2003760973 @default.
• W2557150912 cites W2005898614 @default.
• W2557150912 cites W2005979909 @default.
• W2557150912 cites W2007524354 @default.
• W2557150912 cites W2011698098 @default.
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• W2557150912 cites W2017850777 @default.
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• W2557150912 cites W2024753390 @default.
• W2557150912 cites W2025012947 @default.
• W2557150912 cites W2027560783 @default.
• W2557150912 cites W2028143248 @default.
• W2557150912 cites W2033923082 @default.
• W2557150912 cites W2034858845 @default.
• W2557150912 cites W2036181226 @default.
• W2557150912 cites W2037288608 @default.
• W2557150912 cites W2038889556 @default.
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• W2557150912 cites W2048704317 @default.
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• W2557150912 cites W2066395419 @default.
• W2557150912 cites W2074749191 @default.
• W2557150912 cites W2079882133 @default.
• W2557150912 cites W2081309321 @default.
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• W2557150912 cites W2092604097 @default.
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• W2557150912 doi "https://doi.org/10.1021/acs.cgd.6b01424" @default.
• W2557150912 hasPublicationYear "2016" @default.
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