FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557156634> ?p ?o ?g. }

• W2557156634 abstract "The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect of empagliflozin on metabolic syndrome rats with prediabetes.SHR/NDmcr-cp(+/+) rats (SHRcp), a model of metabolic syndrome with prediabetes, were given empagliflozin for 10 weeks to examine the effects on urinary sodium and water balance, visceral and subcutaneous adipocyte, and cardiac injury. Further, the effect of empagliflozin on blood pressure and autonomic nervous system was continuously investigated by using radiotelemetry system.Empagliflozin significantly reduced urinary sodium and water balance of SHRcp only within 1 week of the treatment, but later than 1 week did not alter them throughout the treatment. Empagliflozin significantly reduced body weight of SHRcp, which was mainly attributed to the significant reduction of subcutaneous fat mass. Empagliflozin significantly reduced the size of visceral adipocytes and increased the number of smaller size of adipocytes, which was associated with the attenuation of oxidative stress. Empagliflozin ameliorated cardiac hypertrophy and fibrosis of SHRcp, in association with the attenuation of cardiac oxidative stress and inflammation. However, empagliflozin did not significantly change blood pressure, heart rate, sympathetic activity, or baroreceptor function, as evidenced by radiotelemetry analysis.Our present work provided the evidence that SGLT2 inhibition reduced visceral adipocytes hypertrophy and ameliorated cardiac injury in prediabetic metabolic syndrome rat, independently of diuretic effect or blood pressure lowering effect. Thus, SGLT2 inhibition seems to be a promising therapeutic strategy for prediabetic metabolic syndrome." @default.
• W2557156634 created "2016-11-30" @default.
• W2557156634 creator A5020090012 @default.
• W2557156634 creator A5025874938 @default.
• W2557156634 creator A5059857726 @default.
• W2557156634 creator A5062992073 @default.
• W2557156634 creator A5073895884 @default.
• W2557156634 date "2016-11-11" @default.
• W2557156634 modified "2023-10-15" @default.
• W2557156634 title "Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome" @default.
• W2557156634 cites W172609984 @default.
• W2557156634 cites W1967465122 @default.
• W2557156634 cites W1990411608 @default.
• W2557156634 cites W1996042816 @default.
• W2557156634 cites W2003567005 @default.
• W2557156634 cites W2010055261 @default.
• W2557156634 cites W2014531748 @default.
• W2557156634 cites W2024878386 @default.
• W2557156634 cites W2028605148 @default.
• W2557156634 cites W2049826664 @default.
• W2557156634 cites W2055416829 @default.
• W2557156634 cites W2057651652 @default.
• W2557156634 cites W2064130493 @default.
• W2557156634 cites W2072040765 @default.
• W2557156634 cites W2080449229 @default.
• W2557156634 cites W2089939599 @default.
• W2557156634 cites W2096632056 @default.
• W2557156634 cites W2117512154 @default.
• W2557156634 cites W2120100339 @default.
• W2557156634 cites W2120359664 @default.
• W2557156634 cites W2123799914 @default.
• W2557156634 cites W2123946565 @default.
• W2557156634 cites W2124658554 @default.
• W2557156634 cites W2127854619 @default.
• W2557156634 cites W2129129201 @default.
• W2557156634 cites W2131411448 @default.
• W2557156634 cites W2133931932 @default.
• W2557156634 cites W2134304394 @default.
• W2557156634 cites W2138173919 @default.
• W2557156634 cites W2139000416 @default.
• W2557156634 cites W2142830692 @default.
• W2557156634 cites W2145466024 @default.
• W2557156634 cites W2146264128 @default.
• W2557156634 cites W2147081693 @default.
• W2557156634 cites W2147663252 @default.
• W2557156634 cites W2148540003 @default.
• W2557156634 cites W2171294019 @default.
• W2557156634 cites W2171786511 @default.
• W2557156634 cites W2202866687 @default.
• W2557156634 cites W2273304042 @default.
• W2557156634 cites W2294512307 @default.
• W2557156634 cites W2295467143 @default.
• W2557156634 cites W2343975335 @default.
• W2557156634 cites W2346113118 @default.
• W2557156634 cites W2506990877 @default.
• W2557156634 doi "https://doi.org/10.1186/s12933-016-0473-7" @default.
• W2557156634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5106779" @default.
• W2557156634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27835975" @default.
• W2557156634 hasPublicationYear "2016" @default.
• W2557156634 type Work @default.
• W2557156634 sameAs 2557156634 @default.
• W2557156634 citedByCount "115" @default.
• W2557156634 countsByYear W25571566342017 @default.
• W2557156634 countsByYear W25571566342018 @default.
• W2557156634 countsByYear W25571566342019 @default.
• W2557156634 countsByYear W25571566342020 @default.
• W2557156634 countsByYear W25571566342021 @default.
• W2557156634 countsByYear W25571566342022 @default.
• W2557156634 countsByYear W25571566342023 @default.
• W2557156634 crossrefType "journal-article" @default.
• W2557156634 hasAuthorship W2557156634A5020090012 @default.
• W2557156634 hasAuthorship W2557156634A5025874938 @default.
• W2557156634 hasAuthorship W2557156634A5059857726 @default.
• W2557156634 hasAuthorship W2557156634A5062992073 @default.
• W2557156634 hasAuthorship W2557156634A5073895884 @default.
• W2557156634 hasBestOaLocation W25571566341 @default.
• W2557156634 hasConcept C126322002 @default.
• W2557156634 hasConcept C134018914 @default.
• W2557156634 hasConcept C2775887513 @default.
• W2557156634 hasConcept C2777180221 @default.
• W2557156634 hasConcept C2779668308 @default.
• W2557156634 hasConcept C2780578515 @default.
• W2557156634 hasConcept C555293320 @default.
• W2557156634 hasConcept C71924100 @default.
• W2557156634 hasConceptScore W2557156634C126322002 @default.
• W2557156634 hasConceptScore W2557156634C134018914 @default.
• W2557156634 hasConceptScore W2557156634C2775887513 @default.
• W2557156634 hasConceptScore W2557156634C2777180221 @default.
• W2557156634 hasConceptScore W2557156634C2779668308 @default.
• W2557156634 hasConceptScore W2557156634C2780578515 @default.
• W2557156634 hasConceptScore W2557156634C555293320 @default.
• W2557156634 hasConceptScore W2557156634C71924100 @default.
• W2557156634 hasFunder F4320306257 @default.
• W2557156634 hasIssue "1" @default.
• W2557156634 hasLocation W25571566341 @default.
• W2557156634 hasLocation W25571566342 @default.
• W2557156634 hasLocation W25571566343 @default.
• W2557156634 hasLocation W25571566344 @default.
• W2557156634 hasOpenAccess W2557156634 @default.
• W2557156634 hasPrimaryLocation W25571566341 @default.

• next