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- W2557183800 abstract "Significance The tumor microenvironment is now considered to play a major role in cancer growth and metastasis. Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity that is highly implicated in tumor growth, metastasis, and inflammation. Here we provide evidence that heparanase is critically required for the activation and function of macrophages, an important constituent of the tumor microenvironment. Mechanistically, we describe a linear cascade by which heparanase activates Erk, p38, and JNK signaling in macrophages, leading to increased c-Fos levels and induction of cytokine expression in a manner that apparently does not require heparanase enzymatic activity. These results identify heparanase as a key mediator of macrophage activation and function in tumorigenesis and cross-talk with the tumor microenvironment." @default.
- W2557183800 created "2016-11-30" @default.
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- W2557183800 date "2016-11-14" @default.
- W2557183800 modified "2023-10-16" @default.
- W2557183800 title "Heparanase is required for activation and function of macrophages" @default.
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- W2557183800 doi "https://doi.org/10.1073/pnas.1611380113" @default.
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