FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557204736> ?p ?o ?g. }

• W2557204736 abstract "Objective: Determine associations of PD with PCBs and investigate modification by variants in the xenobiotic-efflux membrane transporter p-glycoprotein gene ( ABCB1 , p-gp, MDR1 ) Background: PCBs have been inconsistently associated with PD risk. We recently reported significantly increased risk associated with higher serum PCBs in an Alaska Native population and much stronger associations in persons with ABCB1 variants. Here we investigate those associations in another population. Methods: We recruited people with PD (PwPD) and matched controls from the Agricultural Health Study cohort of pesticide applicators and their spouses. PD was confirmed by expert consensus. We genotyped ABCB1 single nucleotide polymorphisms (SNPs) using an Illumina custom array, and measured 15 PCB-congeners in serum using GC-MS. We adjusted for total lipid and used β-substitution to impute undetectable values, and also analyzed summed levels of PCB-118, 138, 153 and 180 (PCB_sum). We assessed associations with PD using logistic regression adjusting for age, gender and state, and examined multiplicative interactions of PCBs and SNPs. Results: Analyses included 97 PwPD and 113 controls. All PCBs were higher in PwPD. For PCB_Sum, compared with the lowest quartile (Q1), odds ratios for Q2, Q3 and Q4 were 1.7, 2.5 and 2.7, respectively (p-trend 0.02). ABCB1 coding variant rs9282564 modified PD-PCB associations: relative to those with below-median PCB_sum, above-median PCB_sum was associated with 1.4-fold (95[percnt]CI 0.7-2.8) greater risk in those with AA genotype, but 11.4-fold (95[percnt]CI 2.8-45) greater risk in those with AG or GG genotype (p-interaction 0.008). Conclusions: In this primarily Caucasian population, as in the Alaska Native population, PCB levels were higher in PwPD than controls. Risk was markedly increased in persons with both above median PCB levels and variants in ABCB1 , suggesting a gene-environment interaction. Study Supported by: NIEHS-R01-ES10803, NIH Intramural Research Program (NIEHS-Z01-ES044007, Z01-ES049030; NCI-Z01-CP010119), Michael J. Fox Foundation, James and Sharron Clark. Disclosure: Dr. Goldman has nothing to disclose. Dr. Kamel has nothing to disclose. Dr. Meng has nothing to disclose. Dr. Korell has nothing to disclose. Dr. Comyns has nothing to disclose. Dr. Umbach has nothing to disclose. Dr. Hoppin has nothing to disclose. Dr. Ross has nothing to disclose. Dr. Marras has nothing to disclose. Dr. Kasten has nothing to disclose. Dr. Chade has nothing to disclose. Dr. Blair has nothing to disclose. Dr. Tanner has received personal compensation for activities with Neurocrine and Ultragenyx Pharmaceuticals as a consultant." @default.
• W2557204736 created "2016-11-30" @default.
• W2557204736 creator A5020974206 @default.
• W2557204736 creator A5023605199 @default.
• W2557204736 creator A5029276357 @default.
• W2557204736 creator A5029944513 @default.
• W2557204736 creator A5036278452 @default.
• W2557204736 creator A5040183748 @default.
• W2557204736 creator A5053232236 @default.
• W2557204736 creator A5054171098 @default.
• W2557204736 creator A5055571990 @default.
• W2557204736 creator A5067994087 @default.
• W2557204736 creator A5069996052 @default.
• W2557204736 creator A5077613299 @default.
• W2557204736 creator A5080273687 @default.
• W2557204736 date "2016-04-05" @default.
• W2557204736 modified "2023-09-23" @default.
• W2557204736 title "Polychlorinated Biphenyls (PCBs) and Parkinson's Disease (PD): Effect Modification by Membrane Transporter Variants (S32.004)" @default.
• W2557204736 hasPublicationYear "2016" @default.
• W2557204736 type Work @default.
• W2557204736 sameAs 2557204736 @default.
• W2557204736 citedByCount "0" @default.
• W2557204736 crossrefType "journal-article" @default.
• W2557204736 hasAuthorship W2557204736A5020974206 @default.
• W2557204736 hasAuthorship W2557204736A5023605199 @default.
• W2557204736 hasAuthorship W2557204736A5029276357 @default.
• W2557204736 hasAuthorship W2557204736A5029944513 @default.
• W2557204736 hasAuthorship W2557204736A5036278452 @default.
• W2557204736 hasAuthorship W2557204736A5040183748 @default.
• W2557204736 hasAuthorship W2557204736A5053232236 @default.
• W2557204736 hasAuthorship W2557204736A5054171098 @default.
• W2557204736 hasAuthorship W2557204736A5055571990 @default.
• W2557204736 hasAuthorship W2557204736A5067994087 @default.
• W2557204736 hasAuthorship W2557204736A5069996052 @default.
• W2557204736 hasAuthorship W2557204736A5077613299 @default.
• W2557204736 hasAuthorship W2557204736A5080273687 @default.
• W2557204736 hasConcept C104317684 @default.
• W2557204736 hasConcept C107872376 @default.
• W2557204736 hasConcept C126322002 @default.
• W2557204736 hasConcept C134018914 @default.
• W2557204736 hasConcept C135763542 @default.
• W2557204736 hasConcept C143998085 @default.
• W2557204736 hasConcept C151956035 @default.
• W2557204736 hasConcept C153209595 @default.
• W2557204736 hasConcept C156957248 @default.
• W2557204736 hasConcept C185592680 @default.
• W2557204736 hasConcept C2776365360 @default.
• W2557204736 hasConcept C2908647359 @default.
• W2557204736 hasConcept C44249647 @default.
• W2557204736 hasConcept C54355233 @default.
• W2557204736 hasConcept C68443243 @default.
• W2557204736 hasConcept C71924100 @default.
• W2557204736 hasConcept C72563966 @default.
• W2557204736 hasConcept C86803240 @default.
• W2557204736 hasConcept C99454951 @default.
• W2557204736 hasConceptScore W2557204736C104317684 @default.
• W2557204736 hasConceptScore W2557204736C107872376 @default.
• W2557204736 hasConceptScore W2557204736C126322002 @default.
• W2557204736 hasConceptScore W2557204736C134018914 @default.
• W2557204736 hasConceptScore W2557204736C135763542 @default.
• W2557204736 hasConceptScore W2557204736C143998085 @default.
• W2557204736 hasConceptScore W2557204736C151956035 @default.
• W2557204736 hasConceptScore W2557204736C153209595 @default.
• W2557204736 hasConceptScore W2557204736C156957248 @default.
• W2557204736 hasConceptScore W2557204736C185592680 @default.
• W2557204736 hasConceptScore W2557204736C2776365360 @default.
• W2557204736 hasConceptScore W2557204736C2908647359 @default.
• W2557204736 hasConceptScore W2557204736C44249647 @default.
• W2557204736 hasConceptScore W2557204736C54355233 @default.
• W2557204736 hasConceptScore W2557204736C68443243 @default.
• W2557204736 hasConceptScore W2557204736C71924100 @default.
• W2557204736 hasConceptScore W2557204736C72563966 @default.
• W2557204736 hasConceptScore W2557204736C86803240 @default.
• W2557204736 hasConceptScore W2557204736C99454951 @default.
• W2557204736 hasOpenAccess W2557204736 @default.
• W2557204736 hasRelatedWork W1989457273 @default.
• W2557204736 hasRelatedWork W2050740748 @default.
• W2557204736 hasRelatedWork W2073408276 @default.
• W2557204736 hasRelatedWork W2087235708 @default.
• W2557204736 hasRelatedWork W2337611787 @default.
• W2557204736 hasRelatedWork W2349473182 @default.
• W2557204736 hasRelatedWork W2350285034 @default.
• W2557204736 hasRelatedWork W2412821094 @default.
• W2557204736 hasRelatedWork W2416200132 @default.
• W2557204736 hasRelatedWork W2467352898 @default.
• W2557204736 hasRelatedWork W2565014564 @default.
• W2557204736 hasRelatedWork W2901576772 @default.
• W2557204736 hasRelatedWork W2939668702 @default.
• W2557204736 hasRelatedWork W3000069740 @default.
• W2557204736 hasRelatedWork W3132261856 @default.
• W2557204736 hasRelatedWork W2467998029 @default.
• W2557204736 hasVolume "86" @default.
• W2557204736 isParatext "false" @default.
• W2557204736 isRetracted "false" @default.
• W2557204736 magId "2557204736" @default.
• W2557204736 workType "article" @default.