Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557210462> ?p ?o ?g. }
- W2557210462 endingPage "12610" @default.
- W2557210462 startingPage "12598" @default.
- W2557210462 abstract "Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How these regulatory B cells (B regs ) suppress the immune response remains to be worked out in detail. In this article, we show that B regs can induce the formation of conventional FoxP3 + regulatory T cells (T regs ), as well as a more recently described CD49b + CD223 + regulatory T-cell subset, known as type 1 regulatory T cells (Tr1s). When B regs are transferred into mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, they home to the spleen and mesenteric lymph nodes, leading to an expansion of T regs and Tr1 in vivo . T regs and Tr1s are also found in greater proportions in the CNS of mice with EAE treated with B regs and are correlated with the remission of symptoms. The discovery that B regs induce the formation of regulatory T-cell subsets in vivo may herald their use as immunosuppressive agents in adoptive cellular therapies for autoimmune pathologies. SIGNIFICANCE STATEMENT Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How regulatory B cells (B regs ) suppress the immune response remains to be fully understood. In this article, we show that B regs can induce the formation of conventional regulatory T cells (T regs ) as well as type 1 regulatory T cells (Tr1s). When B regs are transferred into mice with experimental autoimmune encephalomyelitis (EAE), they home to secondary lymphoid organs, leading to an expansion of T regs and Tr1s in vivo . T regs and Tr1s are also found in greater proportions in the CNS of mice with EAE treated with B regs and are correlated with the remission of symptoms." @default.
- W2557210462 created "2016-11-30" @default.
- W2557210462 creator A5013653335 @default.
- W2557210462 creator A5014749047 @default.
- W2557210462 creator A5026825527 @default.
- W2557210462 creator A5035215353 @default.
- W2557210462 creator A5068773395 @default.
- W2557210462 creator A5069392551 @default.
- W2557210462 creator A5080540846 @default.
- W2557210462 creator A5080542732 @default.
- W2557210462 creator A5085694265 @default.
- W2557210462 creator A5089458832 @default.
- W2557210462 date "2016-11-07" @default.
- W2557210462 modified "2023-10-12" @default.
- W2557210462 title "Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation" @default.
- W2557210462 cites W1512851684 @default.
- W2557210462 cites W1568245010 @default.
- W2557210462 cites W1816536644 @default.
- W2557210462 cites W1834223844 @default.
- W2557210462 cites W1854638296 @default.
- W2557210462 cites W1896921323 @default.
- W2557210462 cites W1907155709 @default.
- W2557210462 cites W1935840505 @default.
- W2557210462 cites W1972715229 @default.
- W2557210462 cites W1976302032 @default.
- W2557210462 cites W1978601549 @default.
- W2557210462 cites W1980910300 @default.
- W2557210462 cites W1983980454 @default.
- W2557210462 cites W1984223934 @default.
- W2557210462 cites W1995112525 @default.
- W2557210462 cites W2000156766 @default.
- W2557210462 cites W2004660702 @default.
- W2557210462 cites W2006236831 @default.
- W2557210462 cites W2009501393 @default.
- W2557210462 cites W2009705372 @default.
- W2557210462 cites W2019528814 @default.
- W2557210462 cites W2043149094 @default.
- W2557210462 cites W2051543984 @default.
- W2557210462 cites W2053889945 @default.
- W2557210462 cites W2069132539 @default.
- W2557210462 cites W2076291065 @default.
- W2557210462 cites W2076831589 @default.
- W2557210462 cites W2077297620 @default.
- W2557210462 cites W2086080135 @default.
- W2557210462 cites W2087985268 @default.
- W2557210462 cites W2088328410 @default.
- W2557210462 cites W2098412041 @default.
- W2557210462 cites W2104806413 @default.
- W2557210462 cites W2105491136 @default.
- W2557210462 cites W2125373439 @default.
- W2557210462 cites W2134939208 @default.
- W2557210462 cites W2138628339 @default.
- W2557210462 cites W2142871301 @default.
- W2557210462 cites W2146104890 @default.
- W2557210462 cites W2156094245 @default.
- W2557210462 cites W2162170222 @default.
- W2557210462 cites W2165025975 @default.
- W2557210462 cites W2168516002 @default.
- W2557210462 cites W2175600373 @default.
- W2557210462 cites W2185031176 @default.
- W2557210462 cites W2198218567 @default.
- W2557210462 cites W2397929769 @default.
- W2557210462 cites W2607325898 @default.
- W2557210462 doi "https://doi.org/10.1523/jneurosci.1994-16.2016" @default.
- W2557210462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5157105" @default.
- W2557210462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27821578" @default.
- W2557210462 hasPublicationYear "2016" @default.
- W2557210462 type Work @default.
- W2557210462 sameAs 2557210462 @default.
- W2557210462 citedByCount "42" @default.
- W2557210462 countsByYear W25572104622017 @default.
- W2557210462 countsByYear W25572104622018 @default.
- W2557210462 countsByYear W25572104622019 @default.
- W2557210462 countsByYear W25572104622020 @default.
- W2557210462 countsByYear W25572104622021 @default.
- W2557210462 countsByYear W25572104622022 @default.
- W2557210462 countsByYear W25572104622023 @default.
- W2557210462 crossrefType "journal-article" @default.
- W2557210462 hasAuthorship W2557210462A5013653335 @default.
- W2557210462 hasAuthorship W2557210462A5014749047 @default.
- W2557210462 hasAuthorship W2557210462A5026825527 @default.
- W2557210462 hasAuthorship W2557210462A5035215353 @default.
- W2557210462 hasAuthorship W2557210462A5068773395 @default.
- W2557210462 hasAuthorship W2557210462A5069392551 @default.
- W2557210462 hasAuthorship W2557210462A5080540846 @default.
- W2557210462 hasAuthorship W2557210462A5080542732 @default.
- W2557210462 hasAuthorship W2557210462A5085694265 @default.
- W2557210462 hasAuthorship W2557210462A5089458832 @default.
- W2557210462 hasBestOaLocation W25572104621 @default.
- W2557210462 hasConcept C159654299 @default.
- W2557210462 hasConcept C164027704 @default.
- W2557210462 hasConcept C187316574 @default.
- W2557210462 hasConcept C203014093 @default.
- W2557210462 hasConcept C2776090121 @default.
- W2557210462 hasConcept C2776914184 @default.
- W2557210462 hasConcept C2778296632 @default.
- W2557210462 hasConcept C2778453870 @default.
- W2557210462 hasConcept C2778486448 @default.