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- W2557247739 endingPage "50" @default.
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- W2557247739 abstract "The current chromatographic approaches used in protein purification are not keeping pace with the increasing biopharmaceutical market demand. With the upstream improvements, the bottleneck shifted towards the downstream process. New approaches rely in Anything But Chromatography methodologies and revisiting former techniques with a bioprocess perspective. Protein crystallization and precipitation methods are already implemented in the downstream process of diverse therapeutic biological macromolecules, overcoming the current chromatographic bottlenecks. Promising work is being developed in order to implement crystallization and precipitation in the purification pipeline of high value therapeutic molecules. This review focuses in the role of these two methodologies in current industrial purification processes, and highlights their potential implementation in the purification pipeline of high value therapeutic molecules, overcoming chromatographic holdups." @default.
- W2557247739 created "2016-12-08" @default.
- W2557247739 creator A5018392457 @default.
- W2557247739 creator A5043941093 @default.
- W2557247739 creator A5089977518 @default.
- W2557247739 date "2017-01-01" @default.
- W2557247739 modified "2023-09-29" @default.
- W2557247739 title "Renaissance of protein crystallization and precipitation in biopharmaceuticals purification" @default.
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- W2557247739 doi "https://doi.org/10.1016/j.biotechadv.2016.11.005" @default.
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- W2557247739 hasPublicationYear "2017" @default.
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