FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557281031> ?p ?o ?g. }

• W2557281031 abstract "Abstract Abstract 1039 Background: The association between increase in body mass index (BMI) and development of acute promyelocytic leukemia (APL) has been reported. Interaction of APL cells with bone marrow adipocytes in vitro induces phosphorylation of STAT3 and MAPK, resulting in an anti-apoptotic effect in APL cells. However, the influence of obesity on the prognosis of APL is not well understood. Materials and Methods: To evaluate the effect of obesity on the prognosis of adult APL, we retrospectively analyzed 62 patients under the age of 65 with newly diagnosed APL. Patients who could not be administered intensified chemotherapy, because of either poor performance status or adverse events of chemotherapy, were excluded. Results: Median age of patients was 40 years (range, 14–63). Twenty-five were male and 37 were female. Median follow-up period was 646 days (range, 3–12,558). Median BMI was 22.7 (range, 16.0–33.0). Twenty-six patients diagnosed with APL between 1970 and 1992 had been treated with chemotherapy alone (chemotherapy group), and 36 patients diagnosed between 1995 and 2010 had been treated with all-trans retinoic acid (ATRA) ± chemotherapy (ATRA group). In both groups, the outcome was compared between high-BMI (BMI ≥ 24) and low-BMI (BMI < 24) patients. Eight out of 26 in the chemotherapy group and 16 out of 36 in the ATRA group were high-BMI patients. In the chemotherapy group, complete remission (CR) was obtained in 13 out of 18 (72.2%) low-BMI patients and in only 3 out of 8 (37.5%) high-BMI patients. By day 498, all 3 CR patients with high BMI had relapsed, whereas only 6 out of 13 (46.2%) low-BMI CR patients had relapsed. The 2-year relapse-free survival (RFS) rate, event-free survival (EFS) rate, and overall survival (OS) rate in high-BMI versus low-BMI patients were 0% v 50.5%, 0% v 61.1%, and 12.5% v 42.8%, respectively. Although the relapsed patients were salvaged with ATRA, arsenic trioxide, or allogeneic bone marrow transplantation, OS was significantly worse in high-BMI patients. On the contrary, in the ATRA group, prognosis between high-BMI and low-BMI patients was not statistically different. Rates of CR, relapse, 2-year RFS, EFS, and OS in high-BMI versus low-BMI patients were 87.5% v 94.7%, 35.7% v 38.9%, 73.3% v 46.2%, 55.0% v 52.5%, and 87.5% v 81.1%, respectively. The initial white blood cell (WBC) and platelet counts have been previously reported to be prognostic factors in APL; however, they were not associated with BMI in our study. A WBC count of >10 × 109/L and a platelet count of ≤40 × 109/L were observed in 4 (10.5%) and 28 (73.8%) out of 38 low-BMI, and 4 (16.5%) and 19 (79.2%) out of 24 high-BMI patients, respectively. Conclusions: Our results demonstrate that obesity at diagnosis is a poor prognostic factor in APL, especially in patients not administered ATRA. ATRA overcomes the anti-apoptotic effect of adipocytes for APL cells. Disclosures: No relevant conflicts of interest to declare." @default.
• W2557281031 created "2016-12-08" @default.
• W2557281031 creator A5003660340 @default.
• W2557281031 creator A5003985739 @default.
• W2557281031 creator A5012855479 @default.
• W2557281031 creator A5013781849 @default.
• W2557281031 creator A5014128503 @default.
• W2557281031 creator A5021578396 @default.
• W2557281031 creator A5026105723 @default.
• W2557281031 creator A5029410010 @default.
• W2557281031 creator A5034437021 @default.
• W2557281031 creator A5040425627 @default.
• W2557281031 creator A5043986012 @default.
• W2557281031 creator A5049633500 @default.
• W2557281031 creator A5069634436 @default.
• W2557281031 creator A5074998414 @default.
• W2557281031 creator A5075727703 @default.
• W2557281031 creator A5076536479 @default.
• W2557281031 creator A5079543730 @default.
• W2557281031 creator A5083740330 @default.
• W2557281031 creator A5084326036 @default.
• W2557281031 creator A5090903462 @default.
• W2557281031 date "2010-11-19" @default.
• W2557281031 modified "2023-10-11" @default.
• W2557281031 title "Obesity Is a Poor Prognostic Factor In Acute Promyelocytic Leukemia (APL)." @default.
• W2557281031 doi "https://doi.org/10.1182/blood.v116.21.1039.1039" @default.
• W2557281031 hasPublicationYear "2010" @default.
• W2557281031 type Work @default.
• W2557281031 sameAs 2557281031 @default.
• W2557281031 citedByCount "0" @default.
• W2557281031 crossrefType "journal-article" @default.
• W2557281031 hasAuthorship W2557281031A5003660340 @default.
• W2557281031 hasAuthorship W2557281031A5003985739 @default.
• W2557281031 hasAuthorship W2557281031A5012855479 @default.
• W2557281031 hasAuthorship W2557281031A5013781849 @default.
• W2557281031 hasAuthorship W2557281031A5014128503 @default.
• W2557281031 hasAuthorship W2557281031A5021578396 @default.
• W2557281031 hasAuthorship W2557281031A5026105723 @default.
• W2557281031 hasAuthorship W2557281031A5029410010 @default.
• W2557281031 hasAuthorship W2557281031A5034437021 @default.
• W2557281031 hasAuthorship W2557281031A5040425627 @default.
• W2557281031 hasAuthorship W2557281031A5043986012 @default.
• W2557281031 hasAuthorship W2557281031A5049633500 @default.
• W2557281031 hasAuthorship W2557281031A5069634436 @default.
• W2557281031 hasAuthorship W2557281031A5074998414 @default.
• W2557281031 hasAuthorship W2557281031A5075727703 @default.
• W2557281031 hasAuthorship W2557281031A5076536479 @default.
• W2557281031 hasAuthorship W2557281031A5079543730 @default.
• W2557281031 hasAuthorship W2557281031A5083740330 @default.
• W2557281031 hasAuthorship W2557281031A5084326036 @default.
• W2557281031 hasAuthorship W2557281031A5090903462 @default.
• W2557281031 hasConcept C104317684 @default.
• W2557281031 hasConcept C126322002 @default.
• W2557281031 hasConcept C141071460 @default.
• W2557281031 hasConcept C2776601000 @default.
• W2557281031 hasConcept C2776694085 @default.
• W2557281031 hasConcept C2778336483 @default.
• W2557281031 hasConcept C2780221984 @default.
• W2557281031 hasConcept C2781121885 @default.
• W2557281031 hasConcept C511355011 @default.
• W2557281031 hasConcept C55493867 @default.
• W2557281031 hasConcept C71924100 @default.
• W2557281031 hasConcept C86803240 @default.
• W2557281031 hasConcept C90924648 @default.
• W2557281031 hasConceptScore W2557281031C104317684 @default.
• W2557281031 hasConceptScore W2557281031C126322002 @default.
• W2557281031 hasConceptScore W2557281031C141071460 @default.
• W2557281031 hasConceptScore W2557281031C2776601000 @default.
• W2557281031 hasConceptScore W2557281031C2776694085 @default.
• W2557281031 hasConceptScore W2557281031C2778336483 @default.
• W2557281031 hasConceptScore W2557281031C2780221984 @default.
• W2557281031 hasConceptScore W2557281031C2781121885 @default.
• W2557281031 hasConceptScore W2557281031C511355011 @default.
• W2557281031 hasConceptScore W2557281031C55493867 @default.
• W2557281031 hasConceptScore W2557281031C71924100 @default.
• W2557281031 hasConceptScore W2557281031C86803240 @default.
• W2557281031 hasConceptScore W2557281031C90924648 @default.
• W2557281031 hasLocation W25572810311 @default.
• W2557281031 hasOpenAccess W2557281031 @default.
• W2557281031 hasPrimaryLocation W25572810311 @default.
• W2557281031 hasRelatedWork W1984164961 @default.
• W2557281031 hasRelatedWork W2047870782 @default.
• W2557281031 hasRelatedWork W2069138880 @default.
• W2557281031 hasRelatedWork W2112597372 @default.
• W2557281031 hasRelatedWork W2338351021 @default.
• W2557281031 hasRelatedWork W2387038618 @default.
• W2557281031 hasRelatedWork W2388570800 @default.
• W2557281031 hasRelatedWork W2434306087 @default.
• W2557281031 hasRelatedWork W2434656438 @default.
• W2557281031 hasRelatedWork W2473609360 @default.
• W2557281031 hasRelatedWork W2491655762 @default.
• W2557281031 hasRelatedWork W2510676419 @default.
• W2557281031 hasRelatedWork W2547181837 @default.
• W2557281031 hasRelatedWork W2551246384 @default.
• W2557281031 hasRelatedWork W2558398671 @default.
• W2557281031 hasRelatedWork W2574474263 @default.
• W2557281031 hasRelatedWork W2896927459 @default.
• W2557281031 hasRelatedWork W2979295599 @default.
• W2557281031 hasRelatedWork W3025020146 @default.
• W2557281031 hasRelatedWork W3031686266 @default.

• next