FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557315911> ?p ?o ?g. }

• W2557315911 abstract "Innexins, a large protein family comprising invertebrate gap junction channels, play an essential role in nervous system development and electrical synapse formation. Here we report the cryo-electron microscopy structures of Caenorhabditis elegans innexin-6 (INX-6) gap junction channels at atomic resolution. We find that the arrangements of the transmembrane helices and extracellular loops of the INX-6 monomeric structure are highly similar to those of connexin-26 (Cx26), despite the lack of significant sequence similarity. The INX-6 gap junction channel comprises hexadecameric subunits but reveals the N-terminal pore funnel, consistent with Cx26. The helix-rich cytoplasmic loop and C-terminus are intercalated one-by-one through an octameric hemichannel, forming a dome-like entrance that interacts with N-terminal loops in the pore. These observations suggest that the INX-6 cytoplasmic domains are cooperatively associated with the N-terminal funnel conformation, and an essential linkage of the N-terminal with channel activity is presumably preserved across gap junction families." @default.
• W2557315911 created "2016-12-08" @default.
• W2557315911 creator A5022487976 @default.
• W2557315911 creator A5028119155 @default.
• W2557315911 creator A5030872199 @default.
• W2557315911 date "2016-12-01" @default.
• W2557315911 modified "2023-10-18" @default.
• W2557315911 title "Atomic structure of the innexin-6 gap junction channel determined by cryo-EM" @default.
• W2557315911 cites W1552188451 @default.
• W2557315911 cites W1955421306 @default.
• W2557315911 cites W1972772651 @default.
• W2557315911 cites W1972920523 @default.
• W2557315911 cites W1980035364 @default.
• W2557315911 cites W2014903264 @default.
• W2557315911 cites W2016665408 @default.
• W2557315911 cites W2016845199 @default.
• W2557315911 cites W2029582401 @default.
• W2557315911 cites W2030517878 @default.
• W2557315911 cites W2034110068 @default.
• W2557315911 cites W2036350687 @default.
• W2557315911 cites W2036376383 @default.
• W2557315911 cites W2040499543 @default.
• W2557315911 cites W2043901383 @default.
• W2557315911 cites W2071769324 @default.
• W2557315911 cites W2073949924 @default.
• W2557315911 cites W2082553994 @default.
• W2557315911 cites W2085924667 @default.
• W2557315911 cites W2086812659 @default.
• W2557315911 cites W2090627913 @default.
• W2557315911 cites W2091567243 @default.
• W2557315911 cites W2092289037 @default.
• W2557315911 cites W2097003212 @default.
• W2557315911 cites W2100455255 @default.
• W2557315911 cites W2104234755 @default.
• W2557315911 cites W2106882534 @default.
• W2557315911 cites W2114631362 @default.
• W2557315911 cites W2117818904 @default.
• W2557315911 cites W2121683769 @default.
• W2557315911 cites W2124026197 @default.
• W2557315911 cites W2132629607 @default.
• W2557315911 cites W2143775739 @default.
• W2557315911 cites W2147851692 @default.
• W2557315911 cites W2149360962 @default.
• W2557315911 cites W2152562710 @default.
• W2557315911 cites W2154580873 @default.
• W2557315911 cites W2154714625 @default.
• W2557315911 cites W2161194374 @default.
• W2557315911 cites W2162746575 @default.
• W2557315911 cites W2164659462 @default.
• W2557315911 cites W2175134346 @default.
• W2557315911 cites W2180229411 @default.
• W2557315911 cites W2253702229 @default.
• W2557315911 cites W2255989330 @default.
• W2557315911 cites W2258315314 @default.
• W2557315911 cites W2404622021 @default.
• W2557315911 doi "https://doi.org/10.1038/ncomms13681" @default.
• W2557315911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5146279" @default.
• W2557315911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27905396" @default.
• W2557315911 hasPublicationYear "2016" @default.
• W2557315911 type Work @default.
• W2557315911 sameAs 2557315911 @default.
• W2557315911 citedByCount "101" @default.
• W2557315911 countsByYear W25573159112017 @default.
• W2557315911 countsByYear W25573159112018 @default.
• W2557315911 countsByYear W25573159112019 @default.
• W2557315911 countsByYear W25573159112020 @default.
• W2557315911 countsByYear W25573159112021 @default.
• W2557315911 countsByYear W25573159112022 @default.
• W2557315911 countsByYear W25573159112023 @default.
• W2557315911 crossrefType "journal-article" @default.
• W2557315911 hasAuthorship W2557315911A5022487976 @default.
• W2557315911 hasAuthorship W2557315911A5028119155 @default.
• W2557315911 hasAuthorship W2557315911A5030872199 @default.
• W2557315911 hasBestOaLocation W25573159111 @default.
• W2557315911 hasConcept C118892022 @default.
• W2557315911 hasConcept C121332964 @default.
• W2557315911 hasConcept C12554922 @default.
• W2557315911 hasConcept C127992366 @default.
• W2557315911 hasConcept C158157758 @default.
• W2557315911 hasConcept C185592680 @default.
• W2557315911 hasConcept C18903297 @default.
• W2557315911 hasConcept C2778530040 @default.
• W2557315911 hasConcept C2779965526 @default.
• W2557315911 hasConcept C2780228694 @default.
• W2557315911 hasConcept C515207424 @default.
• W2557315911 hasConcept C54355233 @default.
• W2557315911 hasConcept C55988834 @default.
• W2557315911 hasConcept C79879829 @default.
• W2557315911 hasConcept C8010536 @default.
• W2557315911 hasConcept C86803240 @default.
• W2557315911 hasConcept C95444343 @default.
• W2557315911 hasConceptScore W2557315911C118892022 @default.
• W2557315911 hasConceptScore W2557315911C121332964 @default.
• W2557315911 hasConceptScore W2557315911C12554922 @default.
• W2557315911 hasConceptScore W2557315911C127992366 @default.
• W2557315911 hasConceptScore W2557315911C158157758 @default.
• W2557315911 hasConceptScore W2557315911C185592680 @default.
• W2557315911 hasConceptScore W2557315911C18903297 @default.
• W2557315911 hasConceptScore W2557315911C2778530040 @default.
• W2557315911 hasConceptScore W2557315911C2779965526 @default.

• next