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- W2557322836 abstract "Nanopores have become ubiquitous components of systems for single-molecule manipulation and detection, in particular DNA sequencing where electric field driven translocation of DNA through a nanopore is used to read out the DNA molecule. Here, we present a double-pore system where two nanopores are drilled in parallel through the same solid-state membrane, which offers new opportunities for DNA manipulation. Our experiments and molecular dynamics simulations show that simultaneous electrophoretic capture of a DNA molecule by the two nanopores mechanically traps the molecule, increasing its residence time within the nanopores by orders of magnitude. Remarkably, by using two unequal-sized nanopores, the pore of DNA entry and exit can be discerned from the ionic current blockades, and the translocation direction can be precisely controlled by small differences in the effective force applied to DNA. The mechanical arrest of DNA translocation using a double-pore system can be straightforwardly integrated into any solid-state nanopore platform, including those using optical or transverse-current readouts." @default.
- W2557322836 created "2016-12-08" @default.
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- W2557322836 date "2016-12-01" @default.
- W2557322836 modified "2023-10-17" @default.
- W2557322836 title "Mechanical Trapping of DNA in a Double-Nanopore System" @default.
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- W2557322836 doi "https://doi.org/10.1021/acs.nanolett.6b04642" @default.
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