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- W2557326066 startingPage "e0167125" @default.
- W2557326066 abstract "Huang Qin (root of Scutellaria baicalensis) is a widely used herb in different countries for adjuvant therapy of inflammation, diabetes, hypertension, different kinds of cancer and virus related diseases. Baicalin is the main flavonoid in this herb and has been extensively studied for 30 years. The angiogenic effect of herb Huang Qin extract and baicalin was found 13 years ago, however, the results were controversial with pro-angiogenic effect in some studies and anti-angiogenic effect in others. In this paper, the angiogenic effect of baicalin, its aglycone form baicalein and aqueous extract of Huang Qin was studied in chick embryo chorioallantoic membrane (CAM) model. Dose dependent dual effect was found in both aqueous extract and baicalin, but not in baicalein, in which only inhibitory effect was observed. In order to reveal the cellular and molecular mechanism of how baicalin and baicalein affect angiogenesis, cell proliferation and programmed cell death assays were performed in treated CAM. In addition, quantitative PCR array including 84 angiogenesis related genes was used to detect high and low dosage of baicalin and baicalein responsive genes. Low dose baicalin increased cell proliferation in developing blood vessels through upregulation of multiple angiogenic genes expression, but high dose baicalin induced cell death, performing inhibitory effect on angiogenesis. Both high and low dose of baicalein down regulated the expression of multiple angiogenic genes, decreased cell proliferation, and leads to inhibitory effects on angiogenesis." @default.
- W2557326066 created "2016-12-08" @default.
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- W2557326066 creator A5091113636 @default.
- W2557326066 date "2016-11-30" @default.
- W2557326066 modified "2023-10-18" @default.
- W2557326066 title "Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis" @default.
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- W2557326066 cites W1974241074 @default.
- W2557326066 cites W1978139448 @default.
- W2557326066 cites W1980102481 @default.
- W2557326066 cites W1981725448 @default.
- W2557326066 cites W1984775455 @default.
- W2557326066 cites W1985804036 @default.
- W2557326066 cites W1986713440 @default.
- W2557326066 cites W1988633749 @default.
- W2557326066 cites W1991077173 @default.
- W2557326066 cites W1991249989 @default.
- W2557326066 cites W2000000541 @default.
- W2557326066 cites W2000917383 @default.
- W2557326066 cites W2003128644 @default.
- W2557326066 cites W2017055376 @default.
- W2557326066 cites W2018062382 @default.
- W2557326066 cites W2024405339 @default.
- W2557326066 cites W2026202254 @default.
- W2557326066 cites W2030345222 @default.
- W2557326066 cites W2034057442 @default.
- W2557326066 cites W2034444864 @default.
- W2557326066 cites W2034485827 @default.
- W2557326066 cites W2039544331 @default.
- W2557326066 cites W2040876612 @default.
- W2557326066 cites W2041872083 @default.
- W2557326066 cites W2043852940 @default.
- W2557326066 cites W2049644040 @default.
- W2557326066 cites W2050359740 @default.
- W2557326066 cites W2052147562 @default.
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- W2557326066 cites W2055297061 @default.
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- W2557326066 cites W2066722738 @default.
- W2557326066 cites W2068170043 @default.
- W2557326066 cites W2081199173 @default.
- W2557326066 cites W2082480024 @default.
- W2557326066 cites W2091110171 @default.
- W2557326066 cites W2093051812 @default.
- W2557326066 cites W2096948724 @default.
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- W2557326066 cites W2114623735 @default.
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- W2557326066 cites W2144320730 @default.
- W2557326066 cites W2146800179 @default.
- W2557326066 cites W2148252321 @default.
- W2557326066 cites W2152492593 @default.
- W2557326066 cites W2154242104 @default.
- W2557326066 cites W2158728436 @default.
- W2557326066 cites W2162804111 @default.
- W2557326066 cites W2163038297 @default.
- W2557326066 cites W2163511428 @default.
- W2557326066 cites W2165760175 @default.
- W2557326066 cites W2177487621 @default.
- W2557326066 cites W2290906226 @default.
- W2557326066 cites W2292857877 @default.
- W2557326066 cites W2334955287 @default.
- W2557326066 cites W2338324968 @default.
- W2557326066 cites W2345739416 @default.
- W2557326066 cites W2409339802 @default.
- W2557326066 cites W2411402207 @default.
- W2557326066 cites W2419523727 @default.
- W2557326066 cites W2436909398 @default.
- W2557326066 cites W2465441676 @default.
- W2557326066 cites W2916799720 @default.
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- W2557326066 doi "https://doi.org/10.1371/journal.pone.0167125" @default.
- W2557326066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5130244" @default.
- W2557326066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27902752" @default.
- W2557326066 hasPublicationYear "2016" @default.
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