Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557330147> ?p ?o ?g. }
- W2557330147 abstract "Chronic hepatitis B remains a serious disease, mainly owing to the severe pathological consequences of persistent hepatitis B virus (HBV) infection of carriers, which is difficult to cure using current therapies. When the immune system responds to hepatocytes experiencing rapid HBV replication, effector cells (such as HBV-specific CD8+ T cells, NK cells, NKT cells and other subtypes of immune cells) infiltrate the liver and cause hepatitis. However, precisely how these cells are recruited remains unclear. In the present study, we found that the cytoplasm-translocated Ku70/80 complex in liver-derived cells sensed cytosolic HBV DNA and promoted hepatitis-associated chemokine secretion. Upon sensing HBV DNA, DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and PARP1 were assembled. Then IRF1 was activated and translocated into the nucleus, which upregulated CCL3 and CCL5 expression. Because CCR5, a major chemokine receptor for CCL3 and CCL5, is known to be critical in hepatitis B, Ku70/80 sensing of HBV DNA likely plays a critical role in immune cell recruitment in response to HBV infection." @default.
- W2557330147 created "2016-12-08" @default.
- W2557330147 creator A5004707629 @default.
- W2557330147 creator A5012198733 @default.
- W2557330147 creator A5016477165 @default.
- W2557330147 creator A5041353057 @default.
- W2557330147 creator A5059823034 @default.
- W2557330147 creator A5061810022 @default.
- W2557330147 creator A5065101291 @default.
- W2557330147 creator A5071102309 @default.
- W2557330147 creator A5083130438 @default.
- W2557330147 date "2016-12-05" @default.
- W2557330147 modified "2023-09-26" @default.
- W2557330147 title "Cytoplasm-Translocated Ku70/80 Complex Sensing of HBV DNA Induces Hepatitis-Associated Chemokine Secretion" @default.
- W2557330147 cites W1567785004 @default.
- W2557330147 cites W1600560134 @default.
- W2557330147 cites W1795551994 @default.
- W2557330147 cites W1934619019 @default.
- W2557330147 cites W1951532510 @default.
- W2557330147 cites W1962682498 @default.
- W2557330147 cites W1980923315 @default.
- W2557330147 cites W1982280354 @default.
- W2557330147 cites W1984704941 @default.
- W2557330147 cites W1987376967 @default.
- W2557330147 cites W1991841530 @default.
- W2557330147 cites W2019977471 @default.
- W2557330147 cites W2021736602 @default.
- W2557330147 cites W2033587318 @default.
- W2557330147 cites W2041880635 @default.
- W2557330147 cites W2042433863 @default.
- W2557330147 cites W2053445583 @default.
- W2557330147 cites W2060453248 @default.
- W2557330147 cites W2061631515 @default.
- W2557330147 cites W2075595885 @default.
- W2557330147 cites W2077159378 @default.
- W2557330147 cites W2079716935 @default.
- W2557330147 cites W2079919241 @default.
- W2557330147 cites W2087733503 @default.
- W2557330147 cites W2089247679 @default.
- W2557330147 cites W2091068450 @default.
- W2557330147 cites W2091172564 @default.
- W2557330147 cites W2107495694 @default.
- W2557330147 cites W2117142918 @default.
- W2557330147 cites W2118258530 @default.
- W2557330147 cites W2119954580 @default.
- W2557330147 cites W2125057960 @default.
- W2557330147 cites W2125065061 @default.
- W2557330147 cites W2129135109 @default.
- W2557330147 cites W2130410032 @default.
- W2557330147 cites W2130858592 @default.
- W2557330147 cites W2139936109 @default.
- W2557330147 cites W2144652247 @default.
- W2557330147 cites W2145647240 @default.
- W2557330147 cites W2145732011 @default.
- W2557330147 cites W2153960708 @default.
- W2557330147 cites W2158542519 @default.
- W2557330147 cites W2163671315 @default.
- W2557330147 cites W2165575329 @default.
- W2557330147 cites W2192529786 @default.
- W2557330147 cites W2281848537 @default.
- W2557330147 cites W2380491159 @default.
- W2557330147 cites W2497059924 @default.
- W2557330147 cites W2518120619 @default.
- W2557330147 cites W45534775 @default.
- W2557330147 doi "https://doi.org/10.3389/fimmu.2016.00569" @default.
- W2557330147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5136554" @default.
- W2557330147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27994596" @default.
- W2557330147 hasPublicationYear "2016" @default.
- W2557330147 type Work @default.
- W2557330147 sameAs 2557330147 @default.
- W2557330147 citedByCount "24" @default.
- W2557330147 countsByYear W25573301472017 @default.
- W2557330147 countsByYear W25573301472018 @default.
- W2557330147 countsByYear W25573301472019 @default.
- W2557330147 countsByYear W25573301472020 @default.
- W2557330147 countsByYear W25573301472021 @default.
- W2557330147 countsByYear W25573301472022 @default.
- W2557330147 countsByYear W25573301472023 @default.
- W2557330147 crossrefType "journal-article" @default.
- W2557330147 hasAuthorship W2557330147A5004707629 @default.
- W2557330147 hasAuthorship W2557330147A5012198733 @default.
- W2557330147 hasAuthorship W2557330147A5016477165 @default.
- W2557330147 hasAuthorship W2557330147A5041353057 @default.
- W2557330147 hasAuthorship W2557330147A5059823034 @default.
- W2557330147 hasAuthorship W2557330147A5061810022 @default.
- W2557330147 hasAuthorship W2557330147A5065101291 @default.
- W2557330147 hasAuthorship W2557330147A5071102309 @default.
- W2557330147 hasAuthorship W2557330147A5083130438 @default.
- W2557330147 hasBestOaLocation W25573301471 @default.
- W2557330147 hasConcept C116484652 @default.
- W2557330147 hasConcept C13373296 @default.
- W2557330147 hasConcept C159047783 @default.
- W2557330147 hasConcept C203014093 @default.
- W2557330147 hasConcept C2522874641 @default.
- W2557330147 hasConcept C2776090121 @default.
- W2557330147 hasConcept C2780593183 @default.
- W2557330147 hasConcept C79484868 @default.
- W2557330147 hasConcept C86803240 @default.
- W2557330147 hasConcept C8891405 @default.
- W2557330147 hasConceptScore W2557330147C116484652 @default.