FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557367534> ?p ?o ?g. }

• W2557367534 abstract "Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically and genetically heterogeneous disease. Frequent genetic lesions include alterations of BCL2 and BCL6, as well as aberrations of the RB pathway and the p53 pathway resulting in deregulation of cell cycle progression and apoptosis. MYC translocations and amplifications have been detected in a subset of cases. Recently, MYC was shown to control a major regulatory network in B-cells (Nature Genet. 37; 382–90: 2005). We thus hypothesized that DLBCLs with constitutively active MYC are associated with distinctive genetic and clinical features when compared to cases with wild-type MYC. Thirty seven de novo DLBCLs were analyzed using immunohistochemistry for CD10, bcl6, MUM1, and bcl2 expression, as well as fluorescence in situ hybridization for MYC, BCL2, BCL6, IGH, IGK, and IGL breakpoints and amplifications. The lymphomas were previously extensively characterized for aberrations at the genetic, epigenetic, or protein level of components of the RB pathway (pRb, p16, cyclin D3, cdk4) and the p53 pathway (p53, p14ARF, MDM2, E2F1). Five cases (14%) had MYC alterations (4 breakpoints and 1 amplification). Of the MYC+ DLBCL cases, 2 showed GCB immunophenotype and 3 were of non-GCB type. Perturbation of the p53 pathway components p53, p14ARF, MDM2, and E2F1 were identified in 28%, 16%, 53%, and 20% of the MYC− cases, respectively, and 83% had aberrations of 1 or more p53 pathway component. In contrast, only 1 (20%) of the MYC+ cases had a p53 pathway aberration (MDM2 overexpression; p=0.013). Thus, MYC alterations and p53 pathway aberrations were inversely correlated. RB pathway aberrations were equally frequent among MYC+ (40%) and MYC− (43%) DLBCLs. However, the pattern of aberrations was different. Lack of pRb expression was the only alteration of the RB pathway in the MYC+ DLBCLs, whereas 30 of 31 (97%) MYC− lymphomas had normal pRb expression (p=0.045). p16 alterations (point mutation, deletion, hypermethylation, lack of expression) and/or cyclin D3 overexpression were identified in 12 (38%) MYC− cases but in none of the MYC+ cases (p=0.038). MYC status was also related to cytogenetic BCL2 alterations. Four of 5 (80%) MYC+ DLBCLs showed BCL2 breakpoints or amplification in contrast to 4 of 32 (13%) of MYC− DLBCLs (p=0.005). Furthermore, all MYC+ DLBCLs were bcl2 positive (p=0.05) and MUM1 negative (p=0.022), and the proliferation index was lower in the MYC+ DLBCLs (p=0.038). Clinically, MYC+ DLBCL patients were characterized by advanced stage disease (p=0.037) and high tumor burden (p=0.037) but favorable treatment response (p=0.05). Taken together, our data indicate that DLBCL with MYC alterations constitute a subgroup of DLBCL with distinct clinical and molecular features. The patterns of aberrations of the p53 pathway, the RB pathway, and BCL2 indicate profound differences in the molecular pathogenesis between MYC+ and MYC− DLBCL." @default.
• W2557367534 created "2016-12-08" @default.
• W2557367534 creator A5001430146 @default.
• W2557367534 creator A5008975834 @default.
• W2557367534 creator A5026350723 @default.
• W2557367534 creator A5083801395 @default.
• W2557367534 date "2005-11-16" @default.
• W2557367534 modified "2023-10-18" @default.
• W2557367534 title "Molecular and Clinical Features of Diffuse Large B-Cell Lymphoma with MYC Alterations: Inverse Correlation with p53 Pathway Disruption." @default.
• W2557367534 doi "https://doi.org/10.1182/blood.v106.11.1912.1912" @default.
• W2557367534 hasPublicationYear "2005" @default.
• W2557367534 type Work @default.
• W2557367534 sameAs 2557367534 @default.
• W2557367534 citedByCount "0" @default.
• W2557367534 crossrefType "journal-article" @default.
• W2557367534 hasAuthorship W2557367534A5001430146 @default.
• W2557367534 hasAuthorship W2557367534A5008975834 @default.
• W2557367534 hasAuthorship W2557367534A5026350723 @default.
• W2557367534 hasAuthorship W2557367534A5083801395 @default.
• W2557367534 hasConcept C104317684 @default.
• W2557367534 hasConcept C124942203 @default.
• W2557367534 hasConcept C138626823 @default.
• W2557367534 hasConcept C141231307 @default.
• W2557367534 hasConcept C153911025 @default.
• W2557367534 hasConcept C159654299 @default.
• W2557367534 hasConcept C199835354 @default.
• W2557367534 hasConcept C203014093 @default.
• W2557367534 hasConcept C206936463 @default.
• W2557367534 hasConcept C2776192174 @default.
• W2557367534 hasConcept C2776750431 @default.
• W2557367534 hasConcept C2777537477 @default.
• W2557367534 hasConcept C2777542201 @default.
• W2557367534 hasConcept C2778264664 @default.
• W2557367534 hasConcept C2778453870 @default.
• W2557367534 hasConcept C2778559949 @default.
• W2557367534 hasConcept C2779338263 @default.
• W2557367534 hasConcept C29537977 @default.
• W2557367534 hasConcept C30481170 @default.
• W2557367534 hasConcept C502942594 @default.
• W2557367534 hasConcept C54355233 @default.
• W2557367534 hasConcept C555283112 @default.
• W2557367534 hasConcept C86803240 @default.
• W2557367534 hasConcept C96926380 @default.
• W2557367534 hasConceptScore W2557367534C104317684 @default.
• W2557367534 hasConceptScore W2557367534C124942203 @default.
• W2557367534 hasConceptScore W2557367534C138626823 @default.
• W2557367534 hasConceptScore W2557367534C141231307 @default.
• W2557367534 hasConceptScore W2557367534C153911025 @default.
• W2557367534 hasConceptScore W2557367534C159654299 @default.
• W2557367534 hasConceptScore W2557367534C199835354 @default.
• W2557367534 hasConceptScore W2557367534C203014093 @default.
• W2557367534 hasConceptScore W2557367534C206936463 @default.
• W2557367534 hasConceptScore W2557367534C2776192174 @default.
• W2557367534 hasConceptScore W2557367534C2776750431 @default.
• W2557367534 hasConceptScore W2557367534C2777537477 @default.
• W2557367534 hasConceptScore W2557367534C2777542201 @default.
• W2557367534 hasConceptScore W2557367534C2778264664 @default.
• W2557367534 hasConceptScore W2557367534C2778453870 @default.
• W2557367534 hasConceptScore W2557367534C2778559949 @default.
• W2557367534 hasConceptScore W2557367534C2779338263 @default.
• W2557367534 hasConceptScore W2557367534C29537977 @default.
• W2557367534 hasConceptScore W2557367534C30481170 @default.
• W2557367534 hasConceptScore W2557367534C502942594 @default.
• W2557367534 hasConceptScore W2557367534C54355233 @default.
• W2557367534 hasConceptScore W2557367534C555283112 @default.
• W2557367534 hasConceptScore W2557367534C86803240 @default.
• W2557367534 hasConceptScore W2557367534C96926380 @default.
• W2557367534 hasLocation W25573675341 @default.
• W2557367534 hasOpenAccess W2557367534 @default.
• W2557367534 hasPrimaryLocation W25573675341 @default.
• W2557367534 hasRelatedWork W1974668268 @default.
• W2557367534 hasRelatedWork W1987223676 @default.
• W2557367534 hasRelatedWork W2084895799 @default.
• W2557367534 hasRelatedWork W2127590433 @default.
• W2557367534 hasRelatedWork W2557367534 @default.
• W2557367534 hasRelatedWork W2968608242 @default.
• W2557367534 hasRelatedWork W3024914256 @default.
• W2557367534 hasRelatedWork W3188506540 @default.
• W2557367534 hasRelatedWork W3209556640 @default.
• W2557367534 hasRelatedWork W2479146979 @default.
• W2557367534 isParatext "false" @default.
• W2557367534 isRetracted "false" @default.
• W2557367534 magId "2557367534" @default.
• W2557367534 workType "article" @default.