FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557368153> ?p ?o ?g. }

• W2557368153 endingPage "572" @default.
• W2557368153 startingPage "567" @default.
• W2557368153 abstract "Abstract T-cell–engaging immunotherapies are exciting new approaches to treat patients with acute lymphoblastic leukemia (ALL). These unique agents, which include blinatumomab, a CD3/CD19 bispecific antibody, and chimeric antigen receptor (CAR) modified T cells targeted to CD19 have shown unprecedented remission rates in the relapsed, refractory ALL setting. Cytokine release syndrome (CRS), resulting from the high magnitude of immune activation by these therapies, is the most significant treatment-related toxicity. CRS manifests with fever and malaise and can progress to life-threatening capillary leak with hypoxia and hypotension. The clinical signs of CRS correlate with T-cell activation and high levels of cytokines, including interleukin 6 (IL-6). Tocilizumab, an anti-IL-6 receptor antagonist, is usually effective in the management of severe CRS induced by CAR T cells and has been adopted by most clinical trial programs. With blinatumomab administration, the goal has been to prevent CRS with corticosteroid premedication, disease cytoreduction, and dose adjustments. Collaborative efforts are underway to harmonize the definition and grading system of CRS to allow for better interpretation of toxicities across trials and allow for informed management algorithms." @default.
• W2557368153 created "2016-12-08" @default.
• W2557368153 creator A5047973111 @default.
• W2557368153 creator A5089409657 @default.
• W2557368153 date "2016-12-02" @default.
• W2557368153 modified "2023-10-16" @default.
• W2557368153 title "Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia" @default.
• W2557368153 cites W1545846766 @default.
• W2557368153 cites W1555553634 @default.
• W2557368153 cites W1964173702 @default.
• W2557368153 cites W1967512987 @default.
• W2557368153 cites W1967517831 @default.
• W2557368153 cites W1977380325 @default.
• W2557368153 cites W1987446594 @default.
• W2557368153 cites W1988623079 @default.
• W2557368153 cites W2000297273 @default.
• W2557368153 cites W2023068069 @default.
• W2557368153 cites W2033048812 @default.
• W2557368153 cites W2037873230 @default.
• W2557368153 cites W2038414910 @default.
• W2557368153 cites W2057389857 @default.
• W2557368153 cites W2076560655 @default.
• W2557368153 cites W2076991609 @default.
• W2557368153 cites W2082708772 @default.
• W2557368153 cites W2085453248 @default.
• W2557368153 cites W2087857484 @default.
• W2557368153 cites W2093654081 @default.
• W2557368153 cites W2099570622 @default.
• W2557368153 cites W2105400883 @default.
• W2557368153 cites W2107685938 @default.
• W2557368153 cites W2107925822 @default.
• W2557368153 cites W2108008366 @default.
• W2557368153 cites W2113802879 @default.
• W2557368153 cites W2118241155 @default.
• W2557368153 cites W2118796952 @default.
• W2557368153 cites W2129702476 @default.
• W2557368153 cites W2130122821 @default.
• W2557368153 cites W2141019574 @default.
• W2557368153 cites W2145985838 @default.
• W2557368153 cites W2166295047 @default.
• W2557368153 cites W2170513194 @default.
• W2557368153 doi "https://doi.org/10.1182/asheducation-2016.1.567" @default.
• W2557368153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142489" @default.
• W2557368153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27913530" @default.
• W2557368153 hasPublicationYear "2016" @default.
• W2557368153 type Work @default.
• W2557368153 sameAs 2557368153 @default.
• W2557368153 citedByCount "144" @default.
• W2557368153 countsByYear W25573681532017 @default.
• W2557368153 countsByYear W25573681532018 @default.
• W2557368153 countsByYear W25573681532019 @default.
• W2557368153 countsByYear W25573681532020 @default.
• W2557368153 countsByYear W25573681532021 @default.
• W2557368153 countsByYear W25573681532022 @default.
• W2557368153 countsByYear W25573681532023 @default.
• W2557368153 crossrefType "journal-article" @default.
• W2557368153 hasAuthorship W2557368153A5047973111 @default.
• W2557368153 hasAuthorship W2557368153A5089409657 @default.
• W2557368153 hasBestOaLocation W25573681531 @default.
• W2557368153 hasConcept C126322002 @default.
• W2557368153 hasConcept C143998085 @default.
• W2557368153 hasConcept C203014093 @default.
• W2557368153 hasConcept C2777178219 @default.
• W2557368153 hasConcept C2777701055 @default.
• W2557368153 hasConcept C2778020697 @default.
• W2557368153 hasConcept C2778690821 @default.
• W2557368153 hasConcept C2778957590 @default.
• W2557368153 hasConcept C2779134260 @default.
• W2557368153 hasConcept C2780850621 @default.
• W2557368153 hasConcept C3875195 @default.
• W2557368153 hasConcept C535046627 @default.
• W2557368153 hasConcept C71924100 @default.
• W2557368153 hasConcept C8891405 @default.
• W2557368153 hasConceptScore W2557368153C126322002 @default.
• W2557368153 hasConceptScore W2557368153C143998085 @default.
• W2557368153 hasConceptScore W2557368153C203014093 @default.
• W2557368153 hasConceptScore W2557368153C2777178219 @default.
• W2557368153 hasConceptScore W2557368153C2777701055 @default.
• W2557368153 hasConceptScore W2557368153C2778020697 @default.
• W2557368153 hasConceptScore W2557368153C2778690821 @default.
• W2557368153 hasConceptScore W2557368153C2778957590 @default.
• W2557368153 hasConceptScore W2557368153C2779134260 @default.
• W2557368153 hasConceptScore W2557368153C2780850621 @default.
• W2557368153 hasConceptScore W2557368153C3875195 @default.
• W2557368153 hasConceptScore W2557368153C535046627 @default.
• W2557368153 hasConceptScore W2557368153C71924100 @default.
• W2557368153 hasConceptScore W2557368153C8891405 @default.
• W2557368153 hasIssue "1" @default.
• W2557368153 hasLocation W25573681531 @default.
• W2557368153 hasLocation W25573681532 @default.
• W2557368153 hasLocation W25573681533 @default.
• W2557368153 hasLocation W25573681534 @default.
• W2557368153 hasOpenAccess W2557368153 @default.
• W2557368153 hasPrimaryLocation W25573681531 @default.
• W2557368153 hasRelatedWork W2113677851 @default.
• W2557368153 hasRelatedWork W2557368153 @default.
• W2557368153 hasRelatedWork W2758011629 @default.
• W2557368153 hasRelatedWork W2887078028 @default.

• next