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- W2557378506 abstract "Motivated by these considerations, Chang et al. (1994)searched for DNA sequences that were present in KSIt is now nearly three years since the seminal identifica-lesions and absent in uninvolved tissues. This searchtion of the genome of a novel human herpesvirus inyielded two small fragments of DNA that showed clearKaposi’s sarcoma (KS) specimens by Yuan Chang andhomology toknown herpesvirussequences.Fromthesecolleagues (Chang et al., 1994). Thisdiscovery changedstarting bits of DNA, the whole 170 kb genome hastheface of KSresearch and ignited a passionatedebatenow been cloned in several laboratories; the completeabout the role of this agent in the etiology of the tumor.sequence of one isolate has been published (Russo etSince then, progress in both laboratory and clinical in-al., 1996) and that of a second is nearing completionvestigation has been swift, and both lines of work are(see Niepel et al., 1997). The sequence reveals KSHVconvergingontheview thattheKS-associatedherpesvi-to be a member of the herpes family’s lymphotropicrus (KSHV;also known by itsformaltaxonomic designa-subgroup, whose best-known member is Epstein-Barrtion as human herpesvirus 8) plays a critical role in the virus (EBV).development of this neoplasm. Here we summarize the Not long after the first sighting of the genome, a Bevidence linking virus and disease and consider some cell line (BCBL-1) was identified in which the KSHV ge-of the molecular mechanisms that might underly this nome ispresentin alatent state;treatmentof thesecellsassociation. with phorbol esters induces dramatic lytic replication" @default.
- W2557378506 created "2016-12-08" @default.
- W2557378506 creator A5000505153 @default.
- W2557378506 date "1997-01-01" @default.
- W2557378506 modified "2023-09-23" @default.
- W2557378506 title "KSHV and Kaposi's Sarcoma: Minireview The End of the Beginning?" @default.
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