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- W2557386857 abstract "Selective estrogen receptor modulators have an agonistic and antagonistic effect on estrogen receptors and reduce the risk of vertebral fracture and invasive breast cancer. Estrogen with or without progestin reduces the risk of vertebral, nonvertebral and hip fracture, and colorectal cancer. Tibolone is a synthetic steroid with estrogenic properties, and it reduces the risk of vertebral and non-vertebral fracture and postmenopausal symptoms. Isoflavone derivative ipriflavone does not reduce fracture risk. Intranasal calcitonin reduces the risk of vertebral fracture and pain in acute vertebral fracture. The purely anabolic teriparatide is available for extremely severe osteoporotic patients and for those who do not respond to other types of therapy. It reduces the risk of vertebral and non-vertebral fracture, and is effective in the treatment of glucocorticoid induced osteoporosis. Strontium ranelate reduces the risk of vertebral and non-vertebral fracture, and may be effective for the management of osteoarthritis. The fully human monoclonal antibody denosumab neutralizes the receptor activator of nuclear factor kappa B ligand, and reduces the risk of vertebral, non-vertebral and hip fracture. These agents have variable extra-skeletal side effects." @default.
- W2557386857 created "2016-12-08" @default.
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- W2557386857 date "2013-03-30" @default.
- W2557386857 modified "2023-09-23" @default.
- W2557386857 title "Anti-Osteoporotic Effect, Extra-Skeletal Benefi ts and Risks of Other Agents" @default.
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