FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557389670> ?p ?o ?g. }

• W2557389670 endingPage "123" @default.
• W2557389670 startingPage "113" @default.
• W2557389670 abstract "Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behavior is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition.We review studies that have examined TBI-related alterations in different properties of the functional brain network, including global integration, segregation, centrality and resilience. We focus on functional data using task-related fMRI or resting-state fMRI in patients with TBI of different severity and recovery phase, and consider how graph metrics may inform rehabilitation and enhance efficacy. Moreover, we outline some methodological challenges associated with the examination of functional connectivity in patients with brain injury, including the sample size, parcellation scheme used, node definition and subgroup analyses.The findings suggest that TBI is associated with hyperconnectivity and a suboptimal global integration, characterized by increased connectivity degree and strength and reduced efficiency of functional networks. This altered functional connectivity, also evident in other clinical populations, is attributable to diffuse white matter pathology and reductions in gray and white matter volume. These functional alterations are implicated in post-concussional symptoms, posttraumatic stress and neurocognitive dysfunction after TBI. Finally, the effects of focal lesions have been found to depend critically on topological position and their role in the network.Graph theory is a unique and powerful tool for exploring functional connectivity in brain-injured patients. One limitation is that its results do not provide specific measures about the biophysical mechanism underlying TBI. Continued work in this field will hopefully see graph metrics used as biomarkers to provide more accurate diagnosis and help guide treatment at the individual patient level." @default.
• W2557389670 created "2016-12-08" @default.
• W2557389670 creator A5027880541 @default.
• W2557389670 creator A5033573389 @default.
• W2557389670 creator A5038841141 @default.
• W2557389670 creator A5048522421 @default.
• W2557389670 date "2017-10-01" @default.
• W2557389670 modified "2023-10-14" @default.
• W2557389670 title "Mapping the functional connectome in traumatic brain injury: What can graph metrics tell us?" @default.
• W2557389670 cites W1884913098 @default.
• W2557389670 cites W1891465388 @default.
• W2557389670 cites W1898892862 @default.
• W2557389670 cites W1934393663 @default.
• W2557389670 cites W1965173583 @default.
• W2557389670 cites W1970107990 @default.
• W2557389670 cites W1971609250 @default.
• W2557389670 cites W1971917786 @default.
• W2557389670 cites W1972000597 @default.
• W2557389670 cites W1972012853 @default.
• W2557389670 cites W1977845408 @default.
• W2557389670 cites W1987924998 @default.
• W2557389670 cites W1994379688 @default.
• W2557389670 cites W1996630013 @default.
• W2557389670 cites W1997597973 @default.
• W2557389670 cites W1999529620 @default.
• W2557389670 cites W1999653836 @default.
• W2557389670 cites W2002289944 @default.
• W2557389670 cites W2002367251 @default.
• W2557389670 cites W2003131754 @default.
• W2557389670 cites W2009105636 @default.
• W2557389670 cites W2012214808 @default.
• W2557389670 cites W2012559638 @default.
• W2557389670 cites W2012909638 @default.
• W2557389670 cites W2013034568 @default.
• W2557389670 cites W2013197261 @default.
• W2557389670 cites W2014022174 @default.
• W2557389670 cites W2015356290 @default.
• W2557389670 cites W2015953751 @default.
• W2557389670 cites W2019450648 @default.
• W2557389670 cites W2020641665 @default.
• W2557389670 cites W2024892001 @default.
• W2557389670 cites W2028333462 @default.
• W2557389670 cites W2031852804 @default.
• W2557389670 cites W2033516072 @default.
• W2557389670 cites W2034561608 @default.
• W2557389670 cites W2034968623 @default.
• W2557389670 cites W2039031131 @default.
• W2557389670 cites W2039448553 @default.
• W2557389670 cites W2040701908 @default.
• W2557389670 cites W2041832654 @default.
• W2557389670 cites W2044770804 @default.
• W2557389670 cites W2049090854 @default.
• W2557389670 cites W2055504658 @default.
• W2557389670 cites W2060298007 @default.
• W2557389670 cites W2061961960 @default.
• W2557389670 cites W2062571913 @default.
• W2557389670 cites W2063497316 @default.
• W2557389670 cites W2067219344 @default.
• W2557389670 cites W2068462003 @default.
• W2557389670 cites W2072309592 @default.
• W2557389670 cites W2078286781 @default.
• W2557389670 cites W2078837612 @default.
• W2557389670 cites W2080224340 @default.
• W2557389670 cites W2085369718 @default.
• W2557389670 cites W2088905367 @default.
• W2557389670 cites W2090303884 @default.
• W2557389670 cites W2090668679 @default.
• W2557389670 cites W2097656614 @default.
• W2557389670 cites W2104695012 @default.
• W2557389670 cites W2107337758 @default.
• W2557389670 cites W2109273473 @default.
• W2557389670 cites W2109434518 @default.
• W2557389670 cites W2110441817 @default.
• W2557389670 cites W2110620844 @default.
• W2557389670 cites W2115805615 @default.
• W2557389670 cites W2117296935 @default.
• W2557389670 cites W2130585702 @default.
• W2557389670 cites W2131181615 @default.
• W2557389670 cites W2131681506 @default.
• W2557389670 cites W2132555912 @default.
• W2557389670 cites W2136805080 @default.
• W2557389670 cites W2137368645 @default.
• W2557389670 cites W2138905229 @default.
• W2557389670 cites W2139755434 @default.
• W2557389670 cites W2143178177 @default.
• W2557389670 cites W2144958108 @default.
• W2557389670 cites W2146406922 @default.
• W2557389670 cites W2148459191 @default.
• W2557389670 cites W2157461606 @default.
• W2557389670 cites W2159929956 @default.
• W2557389670 cites W2165487214 @default.
• W2557389670 cites W2167822639 @default.
• W2557389670 cites W2170397957 @default.
• W2557389670 cites W2170921124 @default.
• W2557389670 cites W2189109128 @default.
• W2557389670 cites W2201482002 @default.
• W2557389670 cites W2218324605 @default.
• W2557389670 cites W2224247781 @default.

• next