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• W2557392931 abstract "IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm2 at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model. The Akaike information criterion used to find the best model to fit the data demonstrates that, at short diffusion times, the bi-exponential IVIM model is most appropriate. The results obtained by comparing the experimental data to a dictionary of numerical simulations of the IVIM signal in microvascular networks support the hypothesis that such a bi-exponential behavior can be explained by considering the contribution of two vascular pools: capillaries and somewhat larger vessels." @default.
• W2557392931 created "2016-12-08" @default.
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• W2557392931 date "2016-01-01" @default.
• W2557392931 modified "2023-09-24" @default.
• W2557392931 title "A two-pool model to describe the IVIM cerebral perfusion" @default.
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• W2557392931 doi "https://doi.org/10.1177/0271678x16681310" @default.
• W2557392931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5536805" @default.
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• W2557392931 hasPublicationYear "2016" @default.
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