Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557448924> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2557448924 endingPage "41" @default.
- W2557448924 startingPage "32" @default.
- W2557448924 abstract "Axonal injury occurs during trauma when tissue-scale loads are transferred to individual axons. Computational models are used to understand this transfer and predict the circumstances that cause injury. However, these findings are limited by a lack of validating experimental work examining the mechanics of axons in their in situ state. As a first step towards validation for dynamic stretch, we use contactin-associated protein (Caspr), expressed at the nodes of Ranvier, as a fiduciary marker of quasistatic axonal stretch. We measured changes in the distance between immunolabled Caspr pairs along axons as a function of tissue-level stretch in chick embryo spinal cords harvested from different developmental periods. We then identified and characterized broken axons and adapted a kinematic model published previously by our group (Singh et al., 2015) to estimate average strain thresholds for axon mechanical failure. The distance between Caspr pairs increased with stretch, though not as much as predicted by simple continuum mechanics. For equivalent tissue stretch, greater numbers of broken axons were found at later stages of development. In adapting our kinematic model to predict a breaking threshold strain, we found that breaking thresholds decrease with development stage. When thresholds were split and classified based on kinematic behavior, non-affine, uncoupled axons had higher strain thresholds than affine, coupled axons, corroborating thresholds predicted from in vitro and in vivo preparations. These results provide a valuable launching point for generating more accurate multi-scale models in primary central nervous system injury." @default.
- W2557448924 created "2016-12-08" @default.
- W2557448924 creator A5016394435 @default.
- W2557448924 creator A5026532047 @default.
- W2557448924 creator A5080620661 @default.
- W2557448924 date "2017-01-01" @default.
- W2557448924 modified "2023-09-27" @default.
- W2557448924 title "Estimating axonal strain and failure following white matter stretch using contactin-associated protein as a fiduciary marker" @default.
- W2557448924 cites W1495034373 @default.
- W2557448924 cites W1934091276 @default.
- W2557448924 cites W1963892608 @default.
- W2557448924 cites W1969821478 @default.
- W2557448924 cites W1970911802 @default.
- W2557448924 cites W1977429857 @default.
- W2557448924 cites W1984132448 @default.
- W2557448924 cites W2039677191 @default.
- W2557448924 cites W2056046210 @default.
- W2557448924 cites W2057397497 @default.
- W2557448924 cites W2060199873 @default.
- W2557448924 cites W2069002586 @default.
- W2557448924 cites W2085266659 @default.
- W2557448924 cites W2089342018 @default.
- W2557448924 cites W2096762838 @default.
- W2557448924 cites W2113519237 @default.
- W2557448924 cites W2116838881 @default.
- W2557448924 cites W2117480798 @default.
- W2557448924 cites W2118622797 @default.
- W2557448924 cites W2127635031 @default.
- W2557448924 cites W2130592409 @default.
- W2557448924 cites W2138620886 @default.
- W2557448924 cites W2143635299 @default.
- W2557448924 cites W2147516066 @default.
- W2557448924 doi "https://doi.org/10.1016/j.jbiomech.2016.11.055" @default.
- W2557448924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27939751" @default.
- W2557448924 hasPublicationYear "2017" @default.
- W2557448924 type Work @default.
- W2557448924 sameAs 2557448924 @default.
- W2557448924 citedByCount "9" @default.
- W2557448924 countsByYear W25574489242018 @default.
- W2557448924 countsByYear W25574489242019 @default.
- W2557448924 countsByYear W25574489242021 @default.
- W2557448924 countsByYear W25574489242022 @default.
- W2557448924 crossrefType "journal-article" @default.
- W2557448924 hasAuthorship W2557448924A5016394435 @default.
- W2557448924 hasAuthorship W2557448924A5026532047 @default.
- W2557448924 hasAuthorship W2557448924A5080620661 @default.
- W2557448924 hasConcept C105702510 @default.
- W2557448924 hasConcept C121332964 @default.
- W2557448924 hasConcept C126838900 @default.
- W2557448924 hasConcept C143409427 @default.
- W2557448924 hasConcept C169760540 @default.
- W2557448924 hasConcept C2779530196 @default.
- W2557448924 hasConcept C2781192897 @default.
- W2557448924 hasConcept C39920418 @default.
- W2557448924 hasConcept C57879066 @default.
- W2557448924 hasConcept C71924100 @default.
- W2557448924 hasConcept C74650414 @default.
- W2557448924 hasConcept C86803240 @default.
- W2557448924 hasConceptScore W2557448924C105702510 @default.
- W2557448924 hasConceptScore W2557448924C121332964 @default.
- W2557448924 hasConceptScore W2557448924C126838900 @default.
- W2557448924 hasConceptScore W2557448924C143409427 @default.
- W2557448924 hasConceptScore W2557448924C169760540 @default.
- W2557448924 hasConceptScore W2557448924C2779530196 @default.
- W2557448924 hasConceptScore W2557448924C2781192897 @default.
- W2557448924 hasConceptScore W2557448924C39920418 @default.
- W2557448924 hasConceptScore W2557448924C57879066 @default.
- W2557448924 hasConceptScore W2557448924C71924100 @default.
- W2557448924 hasConceptScore W2557448924C74650414 @default.
- W2557448924 hasConceptScore W2557448924C86803240 @default.
- W2557448924 hasLocation W25574489241 @default.
- W2557448924 hasLocation W25574489242 @default.
- W2557448924 hasOpenAccess W2557448924 @default.
- W2557448924 hasPrimaryLocation W25574489241 @default.
- W2557448924 hasRelatedWork W1971355501 @default.
- W2557448924 hasRelatedWork W1974777185 @default.
- W2557448924 hasRelatedWork W1986942601 @default.
- W2557448924 hasRelatedWork W2016835098 @default.
- W2557448924 hasRelatedWork W2089342018 @default.
- W2557448924 hasRelatedWork W2129470474 @default.
- W2557448924 hasRelatedWork W2536083918 @default.
- W2557448924 hasRelatedWork W2807766690 @default.
- W2557448924 hasRelatedWork W3206137826 @default.
- W2557448924 hasRelatedWork W4286603013 @default.
- W2557448924 hasVolume "51" @default.
- W2557448924 isParatext "false" @default.
- W2557448924 isRetracted "false" @default.
- W2557448924 magId "2557448924" @default.
- W2557448924 workType "article" @default.