FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557468544> ?p ?o ?g. }

• W2557468544 endingPage "e0167095" @default.
• W2557468544 startingPage "e0167095" @default.
• W2557468544 abstract "The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties. Changes in the cerebellum transcriptional networks of mice from a line selectively bred for High voluntary running (H) were profiled relative to an unselected Control (C) line. The environmental modulation of these changes was assessed both in activity environments corresponding to 7 days of Free (F) access to running wheel and to Blocked (B) access on day 7. Overall, 457 genes exhibited a significant (FDR-adjusted P-value < 0.05) genotype-by-environment interaction effect, indicating that activity genotype differences in gene expression depend on environmental access to running. Among these genes, network analysis highlighted 6 genes (Nrgn, Drd2, Rxrg, Gda, Adora2a, and Rab40b) connected by their products that displayed opposite expression patterns in the activity genotype contrast within the B and F environments. The comparison of network expression topologies suggests that selection for high voluntary running is linked to a predominant dysregulation of hub genes in the F environment that enables running whereas a dysregulation of ancillary genes is favored in the B environment that blocks running. Genes associated with locomotor regulation, signaling pathways, reward-processing, goal-focused, and reward-dependent behaviors exhibited significant genotype-by-environment interaction (e.g. Pak6, Adora2a, Drd2, and Arhgap8). Neuropeptide genes including Adcyap1, Cck, Sst, Vgf, Npy, Nts, Penk, and Tac2 and related receptor genes also exhibited significant genotype-by-environment interaction. The majority of the 183 differentially expressed genes between activity genotypes (e.g. Drd1) were under-expressed in C relative to H genotypes and were also under-expressed in B relative to F environments. Our findings indicate that the high voluntary running mouse line studied is a helpful model for understanding the molecular mechanisms in the cerebellum that influence locomotor control and reward-dependent behaviors." @default.
• W2557468544 created "2016-12-08" @default.
• W2557468544 creator A5001434945 @default.
• W2557468544 creator A5001450490 @default.
• W2557468544 creator A5010835897 @default.
• W2557468544 creator A5019388483 @default.
• W2557468544 creator A5053942773 @default.
• W2557468544 creator A5058590776 @default.
• W2557468544 creator A5059051961 @default.
• W2557468544 date "2016-11-28" @default.
• W2557468544 modified "2023-10-17" @default.
• W2557468544 title "Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors" @default.
• W2557468544 cites W134823913 @default.
• W2557468544 cites W1490537199 @default.
• W2557468544 cites W1539013142 @default.
• W2557468544 cites W1548178315 @default.
• W2557468544 cites W1583443197 @default.
• W2557468544 cites W1779512008 @default.
• W2557468544 cites W1817985333 @default.
• W2557468544 cites W1844553425 @default.
• W2557468544 cites W1940629560 @default.
• W2557468544 cites W1971107079 @default.
• W2557468544 cites W1971561248 @default.
• W2557468544 cites W1973251492 @default.
• W2557468544 cites W1973420216 @default.
• W2557468544 cites W1975867021 @default.
• W2557468544 cites W1976403478 @default.
• W2557468544 cites W1976858661 @default.
• W2557468544 cites W1976996431 @default.
• W2557468544 cites W1977404224 @default.
• W2557468544 cites W1977644171 @default.
• W2557468544 cites W1981509058 @default.
• W2557468544 cites W1985618379 @default.
• W2557468544 cites W1988487570 @default.
• W2557468544 cites W1990083194 @default.
• W2557468544 cites W1993973035 @default.
• W2557468544 cites W1994628845 @default.
• W2557468544 cites W1998308393 @default.
• W2557468544 cites W1999109638 @default.
• W2557468544 cites W2001865657 @default.
• W2557468544 cites W2002850925 @default.
• W2557468544 cites W2004476299 @default.
• W2557468544 cites W2007287690 @default.
• W2557468544 cites W2008240705 @default.
• W2557468544 cites W2009955079 @default.
• W2557468544 cites W2011065126 @default.
• W2557468544 cites W2012949542 @default.
• W2557468544 cites W2014250215 @default.
• W2557468544 cites W2014950409 @default.
• W2557468544 cites W2014981122 @default.
• W2557468544 cites W2018881798 @default.
• W2557468544 cites W2020847861 @default.
• W2557468544 cites W2022770014 @default.
• W2557468544 cites W2024365408 @default.
• W2557468544 cites W2026240745 @default.
• W2557468544 cites W2027693921 @default.
• W2557468544 cites W2031175292 @default.
• W2557468544 cites W2035807359 @default.
• W2557468544 cites W2040100950 @default.
• W2557468544 cites W2041053664 @default.
• W2557468544 cites W2041847360 @default.
• W2557468544 cites W2045656102 @default.
• W2557468544 cites W2046784267 @default.
• W2557468544 cites W2046798829 @default.
• W2557468544 cites W2047500129 @default.
• W2557468544 cites W2047820724 @default.
• W2557468544 cites W2048673011 @default.
• W2557468544 cites W2051178577 @default.
• W2557468544 cites W2051663587 @default.
• W2557468544 cites W2052269732 @default.
• W2557468544 cites W2053218541 @default.
• W2557468544 cites W2059508421 @default.
• W2557468544 cites W2060601033 @default.
• W2557468544 cites W2069352124 @default.
• W2557468544 cites W2070830651 @default.
• W2557468544 cites W2071310144 @default.
• W2557468544 cites W2072308607 @default.
• W2557468544 cites W2073929040 @default.
• W2557468544 cites W2074391473 @default.
• W2557468544 cites W2075689527 @default.
• W2557468544 cites W2076112470 @default.
• W2557468544 cites W2077358165 @default.
• W2557468544 cites W2077493929 @default.
• W2557468544 cites W2077707065 @default.
• W2557468544 cites W2081912214 @default.
• W2557468544 cites W2083880061 @default.
• W2557468544 cites W2086641444 @default.
• W2557468544 cites W2089540278 @default.
• W2557468544 cites W2089678845 @default.
• W2557468544 cites W2092269636 @default.
• W2557468544 cites W2092549693 @default.
• W2557468544 cites W2097139733 @default.
• W2557468544 cites W2099652807 @default.
• W2557468544 cites W2099984791 @default.
• W2557468544 cites W2100305481 @default.
• W2557468544 cites W2103408452 @default.
• W2557468544 cites W2106225750 @default.
• W2557468544 cites W2110065044 @default.

• next