FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557482022> ?p ?o ?g. }

• W2557482022 endingPage "328" @default.
• W2557482022 startingPage "319" @default.
• W2557482022 abstract "Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient cohort studies identify significant neuropsychological impairment among HIV-C individuals independent of Tat variability. The present study clarified this discrepancy by examining neuroimaging markers of brain integrity among HIV-C individuals with and without the Tat substitution. Thirty-seven HIV-C individuals with the Tat C31S substitution, 109 HIV-C individuals without the Tat substitution (C31C), and 34 HIV− controls underwent 3T structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Volumes were determined for the caudate, putamen, thalamus, corpus callosum, total gray matter, and total white matter. DTI metrics included fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). Tracts of interest included the anterior thalamic radiation (ATR), cingulum bundle (CING), uncinate fasciculus (UNC), and corpus callosum (CC). HIV+ individuals exhibited smaller volumes in subcortical gray matter, total gray matter and total white matter compared to HIV− controls. HIV+ individuals also exhibited DTI abnormalities across multiple tracts compared to HIV− controls. By contrast, neither volumetric nor diffusion indices differed significantly between the Tat C31S and C31C groups. Tat C31S status is not a sufficient biomarker of HIV-related brain integrity in patient populations. Clinical attention directed at brain health is warranted for all HIV+ individuals, independent of Tat C31S or clade C status." @default.
• W2557482022 created "2016-12-08" @default.
• W2557482022 creator A5002528924 @default.
• W2557482022 creator A5007027286 @default.
• W2557482022 creator A5016469794 @default.
• W2557482022 creator A5030179454 @default.
• W2557482022 creator A5035280361 @default.
• W2557482022 creator A5050560272 @default.
• W2557482022 creator A5059936945 @default.
• W2557482022 creator A5070358573 @default.
• W2557482022 creator A5071345287 @default.
• W2557482022 creator A5073216705 @default.
• W2557482022 creator A5075294940 @default.
• W2557482022 creator A5076031833 @default.
• W2557482022 creator A5076777565 @default.
• W2557482022 creator A5087578556 @default.
• W2557482022 date "2016-12-02" @default.
• W2557482022 modified "2023-09-27" @default.
• W2557482022 title "Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity" @default.
• W2557482022 cites W1526085390 @default.
• W2557482022 cites W1924882206 @default.
• W2557482022 cites W1976243027 @default.
• W2557482022 cites W1980018132 @default.
• W2557482022 cites W1985519018 @default.
• W2557482022 cites W1988900980 @default.
• W2557482022 cites W1990445240 @default.
• W2557482022 cites W1994646934 @default.
• W2557482022 cites W1996974123 @default.
• W2557482022 cites W1999083565 @default.
• W2557482022 cites W2000143280 @default.
• W2557482022 cites W2004293194 @default.
• W2557482022 cites W2007107743 @default.
• W2557482022 cites W2008339309 @default.
• W2557482022 cites W2010957385 @default.
• W2557482022 cites W2029409717 @default.
• W2557482022 cites W2030176178 @default.
• W2557482022 cites W2036785860 @default.
• W2557482022 cites W2039742816 @default.
• W2557482022 cites W2050835504 @default.
• W2557482022 cites W2054897050 @default.
• W2557482022 cites W2057906523 @default.
• W2557482022 cites W2064703363 @default.
• W2557482022 cites W2067442437 @default.
• W2557482022 cites W2068494868 @default.
• W2557482022 cites W2068547302 @default.
• W2557482022 cites W2071881327 @default.
• W2557482022 cites W2074406568 @default.
• W2557482022 cites W2076378132 @default.
• W2557482022 cites W2078325825 @default.
• W2557482022 cites W2079561270 @default.
• W2557482022 cites W2080117797 @default.
• W2557482022 cites W2086401074 @default.
• W2557482022 cites W2089135598 @default.
• W2557482022 cites W2096107364 @default.
• W2557482022 cites W2101135654 @default.
• W2557482022 cites W2104961623 @default.
• W2557482022 cites W2105730743 @default.
• W2557482022 cites W2110208125 @default.
• W2557482022 cites W2110904803 @default.
• W2557482022 cites W2112116737 @default.
• W2557482022 cites W2112778345 @default.
• W2557482022 cites W2114217074 @default.
• W2557482022 cites W2116956383 @default.
• W2557482022 cites W2117009199 @default.
• W2557482022 cites W2118614651 @default.
• W2557482022 cites W2127890285 @default.
• W2557482022 cites W2129650377 @default.
• W2557482022 cites W2135392761 @default.
• W2557482022 cites W2142153651 @default.
• W2557482022 cites W2142608172 @default.
• W2557482022 cites W2143067006 @default.
• W2557482022 cites W2147647246 @default.
• W2557482022 cites W2148726987 @default.
• W2557482022 cites W2150521916 @default.
• W2557482022 cites W2159047279 @default.
• W2557482022 cites W2159295367 @default.
• W2557482022 cites W2162523973 @default.
• W2557482022 cites W2164801701 @default.
• W2557482022 cites W2168844688 @default.
• W2557482022 cites W2323336235 @default.
• W2557482022 cites W2329802697 @default.
• W2557482022 cites W2417926799 @default.
• W2557482022 cites W2473282899 @default.
• W2557482022 cites W2977883299 @default.
• W2557482022 cites W3171418018 @default.
• W2557482022 cites W4252814826 @default.
• W2557482022 cites W574584042 @default.
• W2557482022 doi "https://doi.org/10.1007/s13365-016-0503-y" @default.
• W2557482022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5334278" @default.
• W2557482022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27913960" @default.
• W2557482022 hasPublicationYear "2016" @default.
• W2557482022 type Work @default.
• W2557482022 sameAs 2557482022 @default.
• W2557482022 citedByCount "14" @default.
• W2557482022 countsByYear W25574820222017 @default.
• W2557482022 countsByYear W25574820222018 @default.
• W2557482022 countsByYear W25574820222019 @default.
• W2557482022 countsByYear W25574820222020 @default.

• next