FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557507970> ?p ?o ?g. }

• W2557507970 endingPage "e1006035" @default.
• W2557507970 startingPage "e1006035" @default.
• W2557507970 abstract "Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1β and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation. Some effectors, like Y. pestis YopM, may block inflammasome activation. Here we show that YopM prevents Y. pestis induced activation of the Pyrin inflammasome induced by the RhoA-inhibiting effector YopE, which is a GTPase activating protein. YopM blocks YopE-induced Pyrin-mediated caspase-1 dependent IL-1β/IL-18 production and cell death. We also detected YopM in a complex with Pyrin and kinases RSK1 and PKN1, putative negative regulators of Pyrin. In contrast to wild-type mice, Pyrin deficient mice were also highly susceptible to an attenuated Y. pestis strain lacking YopM, emphasizing the importance of inhibition of Pyrin in vivo. A complex interplay between the Y. pestis T3SS and IL-1β/IL-18 production is evident, involving at least four inflammasome pathways. The secreted effector YopJ triggers caspase-8- dependent IL-1β activation, even when YopM is present. Additionally, the presence of the T3SS needle/translocon activates NLRP3 and NLRC4-dependent IL-1β generation, which is blocked by YopK, but not by YopM. Taken together, the data suggest YopM specificity for obstructing the Pyrin pathway, as the effector does not appear to block Y. pestis-induced NLRP3, NLRC4 or caspase-8 dependent caspase-1 processing. Thus, we identify Y. pestis YopM as a microbial inhibitor of the Pyrin inflammasome. The fact that so many of the Y. pestis T3SS components are participating in regulation of IL-1β/IL-18 release suggests that these effects are essential for maximal control of innate immunity during plague." @default.
• W2557507970 created "2016-12-08" @default.
• W2557507970 creator A5006499471 @default.
• W2557507970 creator A5011242545 @default.
• W2557507970 creator A5011977345 @default.
• W2557507970 creator A5018475996 @default.
• W2557507970 creator A5034107890 @default.
• W2557507970 creator A5046332347 @default.
• W2557507970 creator A5052083872 @default.
• W2557507970 creator A5057997189 @default.
• W2557507970 creator A5077091911 @default.
• W2557507970 creator A5077708146 @default.
• W2557507970 creator A5083728612 @default.
• W2557507970 creator A5087535749 @default.
• W2557507970 creator A5091688364 @default.
• W2557507970 date "2016-12-02" @default.
• W2557507970 modified "2023-10-14" @default.
• W2557507970 title "The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation" @default.
• W2557507970 cites W1627263949 @default.
• W2557507970 cites W1725610956 @default.
• W2557507970 cites W1946177303 @default.
• W2557507970 cites W1965301450 @default.
• W2557507970 cites W1967725137 @default.
• W2557507970 cites W1982474058 @default.
• W2557507970 cites W1987087200 @default.
• W2557507970 cites W2014477644 @default.
• W2557507970 cites W2020908160 @default.
• W2557507970 cites W2023221600 @default.
• W2557507970 cites W2028145763 @default.
• W2557507970 cites W2032897380 @default.
• W2557507970 cites W2033698154 @default.
• W2557507970 cites W2034302810 @default.
• W2557507970 cites W2038269021 @default.
• W2557507970 cites W2039324767 @default.
• W2557507970 cites W2039807807 @default.
• W2557507970 cites W2043661964 @default.
• W2557507970 cites W2055408817 @default.
• W2557507970 cites W2059972136 @default.
• W2557507970 cites W2072899830 @default.
• W2557507970 cites W2073678899 @default.
• W2557507970 cites W2076286334 @default.
• W2557507970 cites W2084272607 @default.
• W2557507970 cites W2089003246 @default.
• W2557507970 cites W2099998176 @default.
• W2557507970 cites W2120118104 @default.
• W2557507970 cites W2120942524 @default.
• W2557507970 cites W2129880161 @default.
• W2557507970 cites W2131795398 @default.
• W2557507970 cites W2141871826 @default.
• W2557507970 cites W2145638464 @default.
• W2557507970 cites W2148581259 @default.
• W2557507970 cites W2148853770 @default.
• W2557507970 cites W2155184228 @default.
• W2557507970 cites W2167092302 @default.
• W2557507970 cites W2168008880 @default.
• W2557507970 cites W2168291332 @default.
• W2557507970 cites W2171511755 @default.
• W2557507970 cites W2319028007 @default.
• W2557507970 cites W2324425986 @default.
• W2557507970 cites W2346706608 @default.
• W2557507970 cites W2418005758 @default.
• W2557507970 cites W2418840180 @default.
• W2557507970 cites W2509835904 @default.
• W2557507970 doi "https://doi.org/10.1371/journal.ppat.1006035" @default.
• W2557507970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5135138" @default.
• W2557507970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27911947" @default.
• W2557507970 hasPublicationYear "2016" @default.
• W2557507970 type Work @default.
• W2557507970 sameAs 2557507970 @default.
• W2557507970 citedByCount "96" @default.
• W2557507970 countsByYear W25575079702017 @default.
• W2557507970 countsByYear W25575079702018 @default.
• W2557507970 countsByYear W25575079702019 @default.
• W2557507970 countsByYear W25575079702020 @default.
• W2557507970 countsByYear W25575079702021 @default.
• W2557507970 countsByYear W25575079702022 @default.
• W2557507970 countsByYear W25575079702023 @default.
• W2557507970 crossrefType "journal-article" @default.
• W2557507970 hasAuthorship W2557507970A5006499471 @default.
• W2557507970 hasAuthorship W2557507970A5011242545 @default.
• W2557507970 hasAuthorship W2557507970A5011977345 @default.
• W2557507970 hasAuthorship W2557507970A5018475996 @default.
• W2557507970 hasAuthorship W2557507970A5034107890 @default.
• W2557507970 hasAuthorship W2557507970A5046332347 @default.
• W2557507970 hasAuthorship W2557507970A5052083872 @default.
• W2557507970 hasAuthorship W2557507970A5057997189 @default.
• W2557507970 hasAuthorship W2557507970A5077091911 @default.
• W2557507970 hasAuthorship W2557507970A5077708146 @default.
• W2557507970 hasAuthorship W2557507970A5083728612 @default.
• W2557507970 hasAuthorship W2557507970A5087535749 @default.
• W2557507970 hasAuthorship W2557507970A5091688364 @default.
• W2557507970 hasBestOaLocation W25575079701 @default.
• W2557507970 hasConcept C104317684 @default.
• W2557507970 hasConcept C130211564 @default.
• W2557507970 hasConcept C136449434 @default.
• W2557507970 hasConcept C139174496 @default.
• W2557507970 hasConcept C203014093 @default.
• W2557507970 hasConcept C2776914184 @default.

• next